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Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: Implications for targeting cancer stem cells (2015)
Journal Article
Williams, A. C., Paraskeva, C., Greenhough, A., Lane, J. D., Collard, T. J., Jones, R. F., …Williams, A. C. (2015). Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: Implications for targeting cancer stem cells. British Journal of Cancer, 112(4), 714-719. https://doi.org/10.1038/bjc.2015.4

© 2015 Cancer Research UK. Background:LGR5 is an important marker of intestinal stem cells and performs its vital functions at the cell membrane. Despite the importance of LGR5 to both normal and cancer stem cell biology, it is not known how microenv... Read More about Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: Implications for targeting cancer stem cells.

Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process (2015)
Journal Article
Chen, G., Bai, Y., Ren, L., Zhu, D., Li, Y., Fang, M., …Doran, O. (2015). Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process. PLoS ONE, 10(1), Article e113194. https://doi.org/10.1371/journal.pone.0113194

© 2015 Chen et al. Steroids metabolism plays an important role in mammals and contributes to quality of pig meat. The main objective of this study was to identify metabolites of androstenone, 17β-estradiol and dihydrotestosterone using primary cultur... Read More about Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process.

The voltammetric behaviour of lead at a hand drawn pencil electrode and its trace determination in water by stripping voltammetry (2015)
Journal Article
Honeychurch, K. C. (2015). The voltammetric behaviour of lead at a hand drawn pencil electrode and its trace determination in water by stripping voltammetry. Analytical Methods, 7(6), 2437-2443. https://doi.org/10.1039/c4ay02987a

© The Royal Society of Chemistry 2015. This is the first reported proof of concept application of pencil drawn electrodes (PDEs) for anodic stripping voltammetric determination of Pb2+ or any metal ion. PDEs offer advantages of economics, simplicity... Read More about The voltammetric behaviour of lead at a hand drawn pencil electrode and its trace determination in water by stripping voltammetry.

A strategic approach for the visualisation of the low abundance protein fatty acid binding protein 7 (2015)
Journal Article
Dean, S. J., Perks, C. C., Rhodes, A., Holly, J. M., & Jarrett, C. (2015). A strategic approach for the visualisation of the low abundance protein fatty acid binding protein 7. American journal of biomedical sciences, 7(1), 15-25. https://doi.org/10.5099/aj150100015

Fatty acid binding protein 7 (FABP7) is a 15kDa protein that plays a role in fatty acid transport, solubilisation and metabolism. It has been found to be overexpressed in triple negative/basal like breast cancer patients. The role of FABP7 in these... Read More about A strategic approach for the visualisation of the low abundance protein fatty acid binding protein 7.

Advancing healthcare sciences through staff, student and service user partnerships (2015)
Journal Article
Rolfe, V. (2015). Advancing healthcare sciences through staff, student and service user partnerships

The reforms to the National Health Service scientific training as part of the Modernising Scientific Careers (MSC) initiative have attempted to streamline the delivery of undergraduate-level education through a core ‘Healthcare Science’ Bachelors pro... Read More about Advancing healthcare sciences through staff, student and service user partnerships.

Thai visitors’ expectations and experiences of explainer interaction within a science museum context (2015)
Journal Article
Sonchaeng, P., Kamolpattana, S., Chen, G., Sonchaen, P., Wilkinson, C., Willey, N., & Bultitude, K. (2015). Thai visitors’ expectations and experiences of explainer interaction within a science museum context. Public Understanding of Science, 24(1), 69-85. https://doi.org/10.1177/0963662514525560

© The Author(s) 2015. In Western literature, there is evidence that museum explainers offer significant potential for enhancing visitors’ learning through influencing their knowledge, content, action, behaviour and attitudes. However, little research... Read More about Thai visitors’ expectations and experiences of explainer interaction within a science museum context.

Café sci East Africa: Talking with young people about science and technology (2015)
Journal Article
Mukhalu, B. K., & Grand, A. (2015). Café sci East Africa: Talking with young people about science and technology. Science Progress, 98(2), 189-191. https://doi.org/10.3184/003685015X14309161574830

When Café Sci started in Ugandan schools in 2009, it was rare for scientists to visit schools to talk about their research. Former students might speak at career days and the National Council for Science and Technology set up occasional school visits... Read More about Café sci East Africa: Talking with young people about science and technology.

Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing (2015)
Journal Article
Guérard, M., Baum, M., Bitsch, A., Eisenbrand, G., Elhajouji, A., Epe, B., …Froetschl, R. (2015). Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing. Mutation Research - Reviews, 763, 181-201. https://doi.org/10.1016/j.mrrev.2014.11.001

© 2014 Elsevier B.V. In genetic toxicology, risk assessment has traditionally adopted linear dose-responses for any compound that causes genotoxic effects. Increasing evidence of non-linear dose-responses, however, suggests potential cellular toleran... Read More about Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing.

Circulating prostaglandins as biomarkers for colorectal cancer? (2015)
Journal Article
Williams, A. C., Greenhough, A., Paraskeva, C., & Williams, A. C. (2015). Circulating prostaglandins as biomarkers for colorectal cancer?. EBioMedicine, 2(2), 105-106. https://doi.org/10.1016/j.ebiom.2015.01.016

Despite increases in our understanding of intestinal tumour biology, colorectal cancer remains a leading cause of cancer-related death worldwide. Most colorectal cancers develop from benign adenomas, presenting an opportunity for early detection and... Read More about Circulating prostaglandins as biomarkers for colorectal cancer?.

Physiological and pathophysiological implications of micromotion activity in urinary bladder function (2015)
Journal Article
Drake, M. J., Vahabi, B., Vahabi, B., & Drake, M. J. (2015). Physiological and pathophysiological implications of micromotion activity in urinary bladder function. Acta Physiologica, 213(2), 360-370. https://doi.org/10.1111/apha.12373

© 2014 Scandinavian Physiological Society. 'Micromotions' is a term signifying the presence of localized microcontractions and microelongations, alongside non-motile areas. The motile areas tend to shift over the bladder surface with time, and the in... Read More about Physiological and pathophysiological implications of micromotion activity in urinary bladder function.

Theoretical considerations for thresholds in chemical carcinogenesis (2015)
Journal Article
Thomas, A. D., Fahrer, J., Johnson, G., & Kaina, B. (2015). Theoretical considerations for thresholds in chemical carcinogenesis. Mutation Research - Reviews, 765, 56-67. https://doi.org/10.1016/j.mrrev.2015.05.001

© 2015 Elsevier B.V. There is increasing evidence for non-linear relationships for gene mutations, chromosomal aberrations and even tumor incidences in response to low doses of genotoxic carcinogens. To attain the biological relevance of such non-lin... Read More about Theoretical considerations for thresholds in chemical carcinogenesis.

The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation (2015)
Journal Article
Wilson, I., Ciuzan, O., Hancock, J. T., Pamfil, D., Wilson, I. D., & Ladomery, M. (2015). The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation. Physiologia Plantarum, 153(1), 1-11. https://doi.org/10.1111/ppl.12286

© 2014 Scandinavian Plant Physiology Society. The class IV glycine-rich RNA-binding proteins are a distinct subgroup within the heterogenous superfamily of glycine-rich proteins (GRPs). They are distinguished by the presence of an RNA-binding domain... Read More about The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation.

Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity (2015)
Journal Article
Hull, J., Patel, V., El Hindy, M., Lee, C., Odeleye, E., Hezwani, M., …Conway, M. (2015). Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity. Journal of Alzheimer's Disease, 45(3), 891-905. https://doi.org/10.3233/JAD-142970

© 2015 - IOS Press and the authors. All rights reserved. Background: The human branched chain aminotransferases (hBCATm, mitochondrial and hBCATc, cytosolic) are major contributors to brain glutamate production. This excitatory neurotransmitter is th... Read More about Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity.

BOB CAT: A large-scale review and delphi consensus for management of Barrett's esophagus with no dysplasia, indefinite for, or low-grade dysplasia (2015)
Journal Article
Nason, K. S., Tham, T. C., Iyer, P. G., Siersema, P. D., Meltzer, S. J., Wong, J. Y., …Rolfe, V. (2015). BOB CAT: A large-scale review and delphi consensus for management of Barrett's esophagus with no dysplasia, indefinite for, or low-grade dysplasia. American Journal of Gastroenterology, 110(5), 662-682. https://doi.org/10.1038/ajg.2015.55

© 2015 by the American College of Gastroenterology. OBJECTIVES:Barrett's esophagus (BE) is a common premalignant lesion for which surveillance is recommended. This strategy is limited by considerable variations in clinical practice. We conducted an i... Read More about BOB CAT: A large-scale review and delphi consensus for management of Barrett's esophagus with no dysplasia, indefinite for, or low-grade dysplasia.

Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis (2015)
Journal Article
Ouden, K. D., Van Balkom, B. W., Slaats, G. G., Wheway, G., Foletto, V., Szymanska, K., …Giles, R. H. (2015). Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis. Journal of Cell Science, 128(24), 4550-4559. https://doi.org/10.1242/jcs.176065

©2015. To investigate the contribution of ion channels to ciliogenesis, we carried out a small interfering RNA (siRNA)-based reverse genetics screen of all ion channels in the mouse genome in murine inner medullary collecting duct kidney cells. This... Read More about Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis.

The redox switch that regulates molecular chaperones (2015)
Journal Article
Conway, M. E., & Lee, C. (2015). The redox switch that regulates molecular chaperones. BioMolecular Concepts, 6(4), 269-284. https://doi.org/10.1515/bmc-2015-0015

© 2015 by De Gruyter. Modification of reactive cysteine residues plays an integral role in redox-regulated reactions. Oxidation of thiolate anions to sulphenic acid can result in disulphide bond formation, or overoxidation to sulphonic acid, represen... Read More about The redox switch that regulates molecular chaperones.

Open science (2015)
Journal Article
Grand, A. (2015). Open science. JCOM: Journal of Science Communication, 14(4),

Open science is the most recent paradigm shift in the practice of science. However, it is a practice that has emerged relatively recently and as such, its definition is constantly-shifting and evolving. This commentary describes the historical backgr... Read More about Open science.

Chromosomal ampC mutations in cefpodoxime-resistant, ESBL-negative uropathogenic Escherichia coli (2015)
Journal Article
Lawrance, L. M., Arnold, D. L., Moore, P. C., Lewis, J. A., Moore, P. M., Arnold, D. L., & Lawrance, L. (2015). Chromosomal ampC mutations in cefpodoxime-resistant, ESBL-negative uropathogenic Escherichia coli. British Journal of Biomedical Science, 72(1), 7-11. https://doi.org/10.1080/09674845.2015.11666789

AmpC β-lactamase is an enzyme commonly produced by Escherichia coli that causes resistance to cephalosporins and penicillins. Enzyme production is controlled by the strength of the promoter encoded by the chromosomal ampC gene, with the level of prod... Read More about Chromosomal ampC mutations in cefpodoxime-resistant, ESBL-negative uropathogenic Escherichia coli.