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Circulating prostaglandins as biomarkers for colorectal cancer?

Williams, Ann C.; Greenhough, Alexander; Paraskeva, Chris; Williams, Ann C

Circulating prostaglandins as biomarkers for colorectal cancer? Thumbnail


Ann C. Williams

Chris Paraskeva

Ann C Williams


Despite increases in our understanding of intestinal tumour biology, colorectal cancer remains a leading cause of cancer-related death worldwide. Most colorectal cancers develop from benign adenomas, presenting an opportunity for early detection and intervention prior to the onset of malignancy. For patients with early-stage tumours, five year survival rates are high. However, as early-stage tumours are typically asymptomatic, strategies to identify at risk individuals are critical to enable early detection. Therefore, a key challenge is improving (the currently suboptimal) patient uptake to screening programmes, as well as the development of good prognostic and predictive biomarkers for cancer risk and response to treatment. In this context and because of the well-established role of prostaglandins in colorectal tumorigenesis there are an increasing number of studies evaluating the utility of circulating prostaglandins in association with cancer risk and disease progression. In this issue of EBioMedicine, Li et al. (2015) provide evidence suggesting that the measurement of circulating prostaglandins in the blood may have potential utility in identifying patients at risk of developing, or with, colorectal cancer. This is an attractive premise, as a convenient blood-based testmay increase uptake amongst eligible individuals that do not presently participate in current screening procedures (such as the faecal occult blood test).


Williams, A. C., Greenhough, A., Paraskeva, C., & Williams, A. C. (2015). Circulating prostaglandins as biomarkers for colorectal cancer?. EBioMedicine, 2(2), 105-106.

Journal Article Type Note
Acceptance Date Jan 26, 2015
Online Publication Date Jan 28, 2015
Publication Date Jan 1, 2015
Deposit Date Feb 14, 2019
Publicly Available Date Feb 15, 2019
Journal EBioMedicine
Electronic ISSN 2352-3964
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 2
Issue 2
Pages 105-106
Public URL
Publisher URL


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