All Outputs (138)

Investigating mechanisms for non-linear genotoxic responses, and analysing their effects in binary combination (2012)
Journal Article
Jenkins, G. J. S., Doak, S. H., Thomas, A. D., Verma, J. R., Rees, B. J., Lewis, P. D., …Johnson, G. E. (2012). Investigating mechanisms for non-linear genotoxic responses, and analysing their effects in binary combination. Genes and Environment, 34(4), 179-185. https://doi.org/10.3123/jemsge.34.179

A recent shift by the scientific and regulatory community, towards accepting the existence of non-linear dose responses for certain DNA reactive genotoxic agents, has unveiled a myriad of questions regarding their biological basis. The mechanisms res... Read More about Investigating mechanisms for non-linear genotoxic responses, and analysing their effects in binary combination.

Microbial volatile compounds in health and disease conditions (2012)
Journal Article
Thorn, R., & Greenman, J. (2012). Microbial volatile compounds in health and disease conditions. Journal of Breath Research, 6(2), 024001. https://doi.org/10.1088/1752-7155/6/2/024001

Microbial cultures and/or microbial associated diseases often have a characteristic smell. Volatile organic compounds (VOCs) are produced by all microorganisms as part of their normal metabolism. The types and classes of VOC produced is wide, includi... Read More about Microbial volatile compounds in health and disease conditions.

Electrochemically activated solutions: Evidence for antimicrobial efficacy and applications in healthcare environments (2012)
Journal Article
Lee, S. W., Thorn, R., Robinson, G., Greenman, J., & Reynolds, D. M. (2012). Electrochemically activated solutions: Evidence for antimicrobial efficacy and applications in healthcare environments. European Journal of Clinical Microbiology and Infectious Diseases, 31(5), 641-653. https://doi.org/10.1007/s10096-011-1369-9

Due to the limitations associated with the use of existing biocidal agents, there is a need to explore new methods of disinfection to help maintain effective bioburden control, especially within the healthcare environment. The transformation of low m... Read More about Electrochemically activated solutions: Evidence for antimicrobial efficacy and applications in healthcare environments.

The emerging role of lysophosphatidic acid (LPA) in skeletal biology (2012)
Journal Article
Blackburn, J., & Mansell, J. P. (2012). The emerging role of lysophosphatidic acid (LPA) in skeletal biology. BONE, 50(3), 756-762. https://doi.org/10.1016/j.bone.2011.12.002

Lysophosphatidic acid (LPA) is the simplest signalling lipid eliciting pleiotropic actions upon most mammalian cell types. Although LPA has an established role in many biological processes, particularly wound healing and cancer, the participation of... Read More about The emerging role of lysophosphatidic acid (LPA) in skeletal biology.

Does diabetes mellitus-induced bladder remodeling affect lower urinary tract function?: ICI-RS 2011 (2012)
Journal Article
Chacko, S., Birder, L., Kirschner-Hermanns, R., Daneshgari, F., Vahabi, B., & Oelke, M. (2012). Does diabetes mellitus-induced bladder remodeling affect lower urinary tract function?: ICI-RS 2011. Neurourology and Urodynamics, 31(3), 359-364. https://doi.org/10.1002/nau.22228

Aims Due to an increase in aging population and changing eating habits diabetes mellitus (DM) type II is a rapidly increasing condition worldwide. Although not so detrimental as other co-morbidities, uropathy contributes to a significantly reduced qu... Read More about Does diabetes mellitus-induced bladder remodeling affect lower urinary tract function?: ICI-RS 2011.

Application of Modified Atmosphere Packaging and Active/Smart Technologies to Red Meat and Poultry: A Review (2012)
Journal Article
Arvanitoyannis, I. S., & Stratakos, A. C. (2012). Application of Modified Atmosphere Packaging and Active/Smart Technologies to Red Meat and Poultry: A Review. Food and Bioprocess Technology, 5(5), 1423-1446. https://doi.org/10.1007/s11947-012-0803-z

This paper reviews the current advances in modified atmosphere packaging (MAP) of red meat and poultry products. This type of packaging results in shelf-life prolongation by inhibiting microbial growth and promoting oxidative stability, compared to t... Read More about Application of Modified Atmosphere Packaging and Active/Smart Technologies to Red Meat and Poultry: A Review.

Bacterial genomes: Evolution of pathogenicity (2011)
Journal Article
Arnold, D. L., & Jackson, R. W. (2011). Bacterial genomes: Evolution of pathogenicity. Current Opinion in Plant Biology, 14(4), 385-391. https://doi.org/10.1016/j.pbi.2011.03.001

Bacterial pathogens continue to pose a major threat to economically important plant resources. Disease outbreaks can occur through rapid evolution of a pathogen to overcome host defences. The advent of genome sequencing, especially next-generation te... Read More about Bacterial genomes: Evolution of pathogenicity.

Exploiting the brachypodium tool box in cereal and grass research (2011)
Journal Article
Mur, L. A., Allainguillaume, J., Catalán, P., Hasterok, R., Jenkins, G., Lesniewska, K., …Vogel, J. (2011). Exploiting the brachypodium tool box in cereal and grass research. New Phytologist, 191(2), 334-347. https://doi.org/10.1111/j.1469-8137.2011.03748.x

It is now a decade since Brachypodium distachyon (Brachypodium) was suggested as a model species for temperate grasses and cereals. Since then transformation protocols, large expressed sequence tag (EST) databases, tools for forward and reverse genet... Read More about Exploiting the brachypodium tool box in cereal and grass research.

Bladder outlet physiology in the context of lower urinary tract dysfunction (2011)
Journal Article
Sadananda, P., Vahabi, B., & Drake, M. J. (2011). Bladder outlet physiology in the context of lower urinary tract dysfunction. Neurourology and Urodynamics, 30(5), 708-713. https://doi.org/10.1002/nau.21137

Physiological function of the bladder outlet is complex and symptomatic consequences can result from outlet dysfunction. Within the outlet, smooth, and skeletal muscles constitute the contractile apparatus, but additional cell types include interstit... Read More about Bladder outlet physiology in the context of lower urinary tract dysfunction.

Detrusor underactivity: A plea for new approaches to a common bladder dysfunction (2011)
Journal Article
Van Koeveringe, G. A., Vahabi, B., Andersson, K. E., Kirschner-Herrmans, R., & Oelke, M. (2011). Detrusor underactivity: A plea for new approaches to a common bladder dysfunction. Neurourology and Urodynamics, 30(5), 723-728. https://doi.org/10.1002/nau.21097

Aims: Detrusor underactivity (DU) is defined by the International Continence Society as a contraction of reduced strength and/or duration resulting in prolonged or incomplete emptying of the bladder but has yet received only little attention. The pur... Read More about Detrusor underactivity: A plea for new approaches to a common bladder dysfunction.

Bacterial pathogen evolution: Breaking news (2011)
Journal Article
Jackson, R. W., Johnson, L. J., Clarke, S. R., & Arnold, D. L. (2011). Bacterial pathogen evolution: Breaking news. Trends in Genetics, 27(1), 32-40. https://doi.org/10.1016/j.tig.2010.10.001

The immense social and economic impact of bacterial pathogens, from drug-resistant infections in hospitals to the devastation of agricultural resources, has resulted in major investment to understand the causes and consequences of pathogen evolution.... Read More about Bacterial pathogen evolution: Breaking news.

Plant responses to cold: transcriptome analysis of wheat (2010)
Journal Article
Winfield, M. O., Lu, C., Wilson, I. D., Coghill, J. A., & Edwards, K. J. (2010). Plant responses to cold: transcriptome analysis of wheat. Plant Biotechnology Journal, 8(7), 749-771. https://doi.org/10.1111/j.1467-7652.2010.00536.x

Temperature and light are important environmental stimuli that have a profound influence on the growth and development of plants. Wheat varieties can be divided on the basis of whether they require an extended period of cold to flower (vernalization)... Read More about Plant responses to cold: transcriptome analysis of wheat.

American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (2010)
Journal Article
Wittliff, J. L., Sweep, F. C., Osborne, C. K., Mangu, P. B., Hicks, D. G., Goldstein, N. S., …Wolff, A. C. (2010). American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Journal of Clinical Oncology, 28(16), 2784-2795. https://doi.org/10.1200/JCO.2009.25.6529

Purpose: To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers. Methods: The American Socie... Read More about American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.

The challenges of the analysis of basic compounds by high performance liquid chromatography: Some possible approaches for improved separations (2010)
Journal Article
McCalley, D. V. (2010). The challenges of the analysis of basic compounds by high performance liquid chromatography: Some possible approaches for improved separations. Journal of Chromatography A, 1217(6), 858-880. https://doi.org/10.1016/j.chroma.2009.11.068

This review considers some of the difficulties encountered with the analysis of ionised bases using reversed-phase chromatography, such as detrimental interaction with column silanol groups, and overloading which both lead to poor peak shapes. Method... Read More about The challenges of the analysis of basic compounds by high performance liquid chromatography: Some possible approaches for improved separations.

The role of redox mechanisms in cell signalling (2009)
Journal Article
Hancock, J. T. (2009). The role of redox mechanisms in cell signalling. Molecular Biotechnology, 43(2), 162-166. https://doi.org/10.1007/s12033-009-9189-1

Functioning and efficient cell signalling is vital for the survival of cells. Over the years various components have been identified and recognised as crucial for the transduction of signals in cells. Many of the mechanisms allow for a relatively rap... Read More about The role of redox mechanisms in cell signalling.

Current considerations for the effective safety evaluation of drugs in vitro (2009)
Journal Article
Xu, J., & Jackson, S. K. (2009). Current considerations for the effective safety evaluation of drugs in vitro. Mini-Reviews in Medicinal Chemistry, 9(7), 861-868. https://doi.org/10.2174/138955709788452577

As the traditional in vivo tests are gradually shifting into in vitro tests, some new issues become apparent. This review discusses the essential considerations in endpoint selection, cell model quality, exposure concentration and linking factors bet... Read More about Current considerations for the effective safety evaluation of drugs in vitro.

A review of waste management practices and their impact on human health (2009)
Journal Article
Giusti, L. (2009). A review of waste management practices and their impact on human health. Waste Management, 29(8), 2227-2239. https://doi.org/10.1016/j.wasman.2009.03.028

This work reviews (i) the most recent information on waste arisings and waste disposal options in the world, in the European Union (EU), in Organisation for Economic Co-operation and Development (OEDC) countries, and in some developing countries (not... Read More about A review of waste management practices and their impact on human health.

Child maltreatment prevention: A systematic review of reviews (2009)
Journal Article
Mikton, C., & Butchart, A. (2009). Child maltreatment prevention: A systematic review of reviews. Bulletin of the World Health Organization, 87(5), 353-361. https://doi.org/10.2471/BLT.08.057075

Objective: To synthesize recent evidence from systematic and comprehensive reviews on the effectiveness of universal and selective child maltreatment prevention interventions, evaluate the methodological quality of the reviews and outcome evaluation... Read More about Child maltreatment prevention: A systematic review of reviews.

Spontaneous capture of oilseed rape (Brassica napus) chloroplasts by wild B. rapa: Implications for the use of chloroplast transformation for biocontainment (2009)
Journal Article
Haider, N., Allainguillaume, J., & Wilkinson, M. J. (2009). Spontaneous capture of oilseed rape (Brassica napus) chloroplasts by wild B. rapa: Implications for the use of chloroplast transformation for biocontainment. Current Genetics, 55(2), 139-150. https://doi.org/10.1007/s00294-009-0230-5

Environmental concerns over the cultivation of Genetically Modified (GM) crops largely centre on the ecological consequences following gene flow to wild relatives. One attractive solution is to deploy biocontainment measures that prevent hybridizatio... Read More about Spontaneous capture of oilseed rape (Brassica napus) chloroplasts by wild B. rapa: Implications for the use of chloroplast transformation for biocontainment.

The COX-2/PGE2 pathway: Key roles in the hallmarks of cancer and adaptation to the tumour microenvironment (2009)
Journal Article
Kaidi, A., Smartt, H. J., Greenhough, A., Moore, A. E., Roberts, H. R., Williams, A. C., & Paraskeva, C. (2009). The COX-2/PGE2 pathway: Key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis, 30(3), 377-386. https://doi.org/10.1093/carcin/bgp014

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the abundance of its enzymatic product prostaglandin E2 (PGE2) have key roles in influencing the development of colorectal cancer. Deregulation of the COX-2/PGE2 pathwa... Read More about The COX-2/PGE2 pathway: Key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.