Current considerations for the effective safety evaluation of drugs in vitro

Xu, Jinsheng; Jackson, Simon K.

Abstract

As the traditional in vivo tests are gradually shifting into in vitro tests, some new issues become apparent. This review discusses the essential considerations in endpoint selection, cell model quality, exposure concentration and linking factors between in vitro and in vivo studies in using in vitro models in risk assessment. © 2009 Bentham Science Publishers Ltd.

Citation

Xu, J., & Jackson, S. K. (2009). Current considerations for the effective safety evaluation of drugs in vitro. Mini-Reviews in Medicinal Chemistry, 9(7), 861-868. https://doi.org/10.2174/138955709788452577

• Journal Article Type: Review
• Publication Date: Sep 21, 2009
• Journal: Mini-Reviews in Medicinal Chemistry
• Print ISSN: 1389-5575
• Publisher: Bentham Science Publishers
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 7
• Pages: 861-868
• DOI: https://doi.org/10.2174/138955709788452577
• Public URL: https://uwe-repository.worktribe.com/output/995973
• Publisher URL: http://dx.doi.org/10.2174/138955709788452577