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All Outputs (104)

THU0702-HPR Patient understanding of risks of methotrexate and anti-TNF therapy: A cross-sectional study (2019)
Conference Proceeding
Jackson, L., Murray, N., Plummer, Z., Marshall, R., & Ndosi, M. (in press). THU0702-HPR Patient understanding of risks of methotrexate and anti-TNF therapy: A cross-sectional study. In Health Professionals in Rheumatology Abstracts (648-648). https://doi.org/10.1136/annrheumdis-2019-eular.7638

Background: Patient education is an important part of the management of rheumatic and other diseases. Since patients do not have the same needs, it is crucial to assess needs of a targeted group to be able to tailor educational interventions. Obje... Read More about THU0702-HPR Patient understanding of risks of methotrexate and anti-TNF therapy: A cross-sectional study.

Real-world ethics in palliative care: Protocol for a systematic review of the ethical challenges reported by specialist palliative care practitioners in their clinical practice (2019)
Journal Article
Schofield, G., Brangan, E., Dittborn, M., Huxtable, R., & Selman, L. (2019). Real-world ethics in palliative care: Protocol for a systematic review of the ethical challenges reported by specialist palliative care practitioners in their clinical practice. BMJ Open, 9, e028480. https://doi.org/10.1136/bmjopen-2018-028480

Introduction Ethical issues arise daily in the delivery of palliative care. Despite much (largely theoretical) literature, evidence from specialist palliative care practitioners (SPCPs) about real-world ethical challenges has not previously been syn... Read More about Real-world ethics in palliative care: Protocol for a systematic review of the ethical challenges reported by specialist palliative care practitioners in their clinical practice.

Exploring the determinants of mobile health adoption by hospitals in China: Empirical study (2019)
Journal Article
Ramdani, B., Duan, B., & Berrou, I. (2020). Exploring the determinants of mobile health adoption by hospitals in China: Empirical study. JMIR Medical Informatics, 8(7), Article e14795. https://doi.org/10.2196/14795

Background: Although mobile health (mHealth) has the potential to transform health care by delivering better outcomes at a much lower cost than traditional health care services, little is known about mHealth adoption by hospitals. Objective: Thi... Read More about Exploring the determinants of mobile health adoption by hospitals in China: Empirical study.

Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development (2019)
Journal Article
Trefan, L., Akbari, A., Paranjothy, S., Farewell, D. M., Gartner, A., Fone, D., …Moore, S. (2019). Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development. International Journal of Population Data Science, 4(1), https://doi.org/10.23889/ijpds.v4i1.581

Introduction: Excessive alcohol consumption has adverse effects on health and there is a recognised need for the longitudinal analysis of population data to improve our understanding of the patterns of alcohol use, harms to consumers and those in the... Read More about Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development.

Midwives’ perspectives of continuity based working in the UK: A cross-sectional survey (2019)
Journal Article
Taylor, B., Cross-Sudworth, F., Goodwin, L., Kenyon, S., & MacArthur, C. (2019). Midwives’ perspectives of continuity based working in the UK: A cross-sectional survey. Midwifery, 75, 127-137. https://doi.org/10.1016/j.midw.2019.05.005

Objective: UK policy is advocating continuity of midwife throughout the antenatal, intrapartum and postnatal period in order to improve outcomes. We explored the working patterns that midwives are willing and able to adopt, barriers to change, and wh... Read More about Midwives’ perspectives of continuity based working in the UK: A cross-sectional survey.

Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: A systematic review (2019)
Journal Article
Trubey, R., Huang, C., Lugg-Widger, F. V., Hood, K., Allen, D., Edwards, D., …Powell, C. (2019). Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: A systematic review. BMJ Open, 9(5), https://doi.org/10.1136/bmjopen-2018-022105

Objective: To assess (1) how well validated existing paediatric track and trigger tools (PTTT) are for predicting adverse outcomes in hospitalised children, and (2) how effective broader paediatric early warning systems are at reducing adverse outcom... Read More about Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: A systematic review.

Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT) (2019)
Journal Article
Lyttle, M. D., Bielicki, J. A., Barratt, S., Dunn, D., Finn, A., Harper, L., …Sharland, M. (2019). Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT). BMJ Open, 9(5), e029875. https://doi.org/10.1136/bmjopen-2019-029875

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Introduction Community-acquired pneumonia (CAP) is a common indication for antibiotic treatment in young children. Data are limited regarding the ideal dose and... Read More about Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT).

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial (2019)
Journal Article
Crome, L., Nyirenda, M., Sajjanhar, T., Leighton, S., McLellan, S., Bell, C., …Lyttle, M. D. (2019). Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet, 393(10186), 2125-2134. https://doi.org/10.1016/S0140-6736%2819%2930724-X

Background Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This... Read More about Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.

Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis (2019)
Journal Article
Ovadia, C., Perdones‐Montero, A., Spagou, K., Smith, A., Sarafian, M. H., Gomez‐Romero, M., …Williamson, C. (2019). Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis. Hepatology, 70(1), 276-293. https://doi.org/10.1002/hep.30661

Pregnancy is associated with progressive hypercholanemia, hypercholesterolemia, and hypertriglyceridemia, which can result in metabolic disease in susceptible women. Gut signals modify hepatic homeostatic pathways, linking intestinal content to metab... Read More about Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis.

Protocol: An e-Delphi study to define internationally agreed core clinical outcome measures for Complex Regional Pain Syndrome clinical research studies (2019)
Presentation / Conference
Llewellyn, A., Birklein, F., Brunner, F., Goebel, A., Grieve, S., Buckle, L., & McCabe, C. (2019, April). Protocol: An e-Delphi study to define internationally agreed core clinical outcome measures for Complex Regional Pain Syndrome clinical research studies. Poster presented at UWE Centre for Health and Clinical Research Showcase Conference, Bristol, England

Background & objectives: Complex Regional Pain Syndrome (CRPS) is a severe chronic pain condition characterised by a wide range of sensory, motor and autonomic abnormalities, usually in a single limb. CRPS clinical studies have historically used a... Read More about Protocol: An e-Delphi study to define internationally agreed core clinical outcome measures for Complex Regional Pain Syndrome clinical research studies.

Understanding the biopsychosocial impacts of living with Complex Regional Pain Syndrome (2019)
Presentation / Conference
Llewellyn, A., Sweeting, M., & McCabe, C. (2019, April). Understanding the biopsychosocial impacts of living with Complex Regional Pain Syndrome. Poster presented at UWE Centre for Health and Clinical Research Showcase Conference, Bristol, England

Background: Complex Regional Pain Syndrome (CRPS) is a disabling pain condition which commonly follows trauma to a limb, although the exact aetiology is currently unknown. It is characterised by severe, unremitting pain; autonomic, motor and sensor... Read More about Understanding the biopsychosocial impacts of living with Complex Regional Pain Syndrome.

Gastric residual volume measurement in UK paediatric intensive care units: A survey of practice (2019)
Journal Article
Tume, L., Arch, B., Woolfall, K., Latten, L., Deja, E., Roper, L., …Dorling, J. (2019). Gastric residual volume measurement in UK paediatric intensive care units: A survey of practice. Pediatric Critical Care Medicine, 20(8), 707-713. https://doi.org/10.1097/PCC.0000000000001944

Objective: Despite little evidence, the practice of routine measurement of gastric residual volume to guide both the initiation and delivery of enteral feeding in pediatric intensive care units is widespread internationally. In light of increased scr... Read More about Gastric residual volume measurement in UK paediatric intensive care units: A survey of practice.

Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study (2019)
Journal Article
Woolfall, K., Roper, L., Humphreys, A., Lyttle, M. D., Messahel, S., Lee, E., …Appleton, R. (2019). Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study. Trials, 20, Article 181. https://doi.org/10.1186/s13063-019-3273-z

Background: EcLiPSE (Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children) is a randomised controlled trial (RCT) in the United Kingdom. Challenges to success include the need to immediately administer an intervention... Read More about Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study.

The experience of people with rheumatoid arthritis living with fatigue: A qualitative metasynthesis (2019)
Journal Article
Primdahl, J., Hegelund, A., Lorenzen, A. G., Løppenthin, K., Dures, E., & Esbensen, B. A. (2019). The experience of people with rheumatoid arthritis living with fatigue: A qualitative metasynthesis. BMJ Open, 9(3), Article e024338. https://doi.org/10.1136/bmjopen-2018-024338

Objectives To identify, appraise and synthesise qualitative studies on the experience of living with rheumatoid arthritis (RA)-related fatigue. Methods We conducted a qualitative metasynthesis encompassing a systematic literature search in Febr... Read More about The experience of people with rheumatoid arthritis living with fatigue: A qualitative metasynthesis.

Update on outcome measure development in large-vessel vasculitis: Report from OMERACT 2018 (2019)
Journal Article
Merkel, P. A., Direskeneli, H., Tugwell, P., Tómasson, G., Shea, B., Milman, N., …Hill, C. (2019). Update on outcome measure development in large-vessel vasculitis: Report from OMERACT 2018. Journal of Rheumatology, 46(9), 1198-1201. https://doi.org/10.3899/jrheum.181072

OBJECTIVE: The OMERACT Vasculitis Working Group seeks to develop validated outcome measures for use in trials for large-vessel vasculitis (LVV). METHODS: An international Delphi exercise conducted among investigators identified items considered... Read More about Update on outcome measure development in large-vessel vasculitis: Report from OMERACT 2018.

Prospective observational study of vaginal microbiota pre‐ and post‐rescue cervical cerclage (2019)
Journal Article
Brown, R. G., Chan, D., Terzidou, V., Lee, Y. S., Smith, A., Marchesi, J. R., …Bennett, P. R. (2019). Prospective observational study of vaginal microbiota pre‐ and post‐rescue cervical cerclage. BJOG: An International Journal of Obstetrics and Gynaecology, 126(7), 916-925. https://doi.org/10.1111/1471-0528.15600

Objective: To investigate the relation between vaginal microbiota composition and outcome of rescue cervical cerclage. Design: Prospective observational study. Setting: Queen Charlotte's and Chelsea Hospital, London. Population: Twenty singleton preg... Read More about Prospective observational study of vaginal microbiota pre‐ and post‐rescue cervical cerclage.

Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: A multicentre randomized clinical pilot trial (2019)
Journal Article
Peters, M. J., Woolfall, K., Khan, I., Deja, E., Mouncey, P. R., Wulff, J., …Rowan, K. M. (2019). Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: A multicentre randomized clinical pilot trial. Critical Care, 23(1), https://doi.org/10.1186/s13054-019-2354-4

Background: Fever improves pathogen control at a significant metabolic cost. No randomized clinical trials (RCT) have compared fever treatment thresholds in critically ill children. We performed a pilot RCT to determine whether a definitive trial of... Read More about Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: A multicentre randomized clinical pilot trial.