Update on outcome measure development in large-vessel vasculitis: Report from OMERACT 2018

Merkel, Peter A.; Direskeneli, Haner; Tugwell, Peter; T�masson, Gunnar; Shea, Beverley; Milman, Nataliya; Meara, Alexa; Mahr, Alfred; Kermani, Tanaz A.; Hatemi, G�len; Gul, Ahmet; Beard, Susan; Mackie, Sarah; Alibaz-Oner, Fatma; Aydin, Sibel Z.; Robson, Joanna Clare; Sreih, Antoine G.; Hill, Catherine

Abstract

OBJECTIVE:
The OMERACT Vasculitis Working Group seeks to develop validated outcome measures for use in trials for large-vessel vasculitis (LVV).

METHODS:
An international Delphi exercise conducted among investigators identified items considered important to measure active disease. In parallel, qualitative research with patients was conducted, including interviews and focus groups.

RESULTS:
Next steps prioritized by the group for LVV include i) defining disease states (remission, flare, and patient-acceptable symptom state); and ii) selection of patient reported outcome tools.

CONCLUSION:
The ultimate goal is to develop an OMERACT-endorsed Core Set of outcome measures for use in clinical trials of LVV.

• Journal Article Type: Article
• Acceptance Date: Feb 1, 2019
• Online Publication Date: Mar 15, 2019
• Publication Date: Sep 1, 2019
• Deposit Date: Apr 16, 2019
• Publicly Available Date: Mar 16, 2020
• Journal: The Journal of Rheumatology
• Print ISSN: 1499-2752
• Electronic ISSN: 1499-2752
• Publisher: Journal of Rheumatology
• Peer Reviewed: Peer Reviewed
• Volume: 46
• Issue: 9
• Pages: 1198-1201
• DOI: https://doi.org/10.3899/jrheum.181072
• Public URL: https://uwe-repository.worktribe.com/output/850525
• Publisher URL: https://doi.org/10.3899/jrheum.181072
• Additional Information: Additional Information : This is the author's accepted manuscript. The final published version is available here: https://doi.org/10.3899/jrheum.181072.
• Contract Date: Apr 16, 2019