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Protocol: An e-Delphi study to define internationally agreed core clinical outcome measures for Complex Regional Pain Syndrome clinical research studies

Llewellyn, Alison; Birklein, Frank; Brunner, Florian; Goebel, Andreas; Grieve, Sharon; Buckle, Lisa; McCabe, Candy

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Authors

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Alison Llewellyn Alison.Llewellyn@uwe.ac.uk
Associate Professor in Clinical Research

Frank Birklein

Florian Brunner

Andreas Goebel

Lisa Buckle

Candy McCabe Candy.Mccabe@uwe.ac.uk
Professor of Clinical Research and Practice



Abstract

Background & objectives:
Complex Regional Pain Syndrome (CRPS) is a severe chronic pain condition characterised by a wide range of sensory, motor and autonomic abnormalities, usually in a single limb. CRPS clinical studies have historically used a diverse range of outcome measures to capture the multi-dimensional nature of the condition, however this has hindered the meaningful comparison and pooling of data[1]. In response, the COMPACT consortium published recommendations for a minimum core set of patient-reported outcome measures[2] and has established an international registry to collect and manage these data. The current study aims to extend the work of the COMPACT consortium by using an electronic Delphi process to develop a complementary set of clinical outcome measures.

Method:
From a systematic literature review, and subsequent workshop with clinicians and academics, a list of clinical outcomes has been developed for potential inclusion in a core clinical outcome set. In round 1 of the e-Delphi study, CRPS clinicians and researchers internationally will be asked to rate each outcome in relation to its relevance to the question: “What is the clinical presentation and course of CRPS, and what factors influence it?” Free text comments will also be elicited. In round 2, respondents will be presented with their individual ratings, the median group ratings for each item, and anonymised free-text comments. Respondents will be asked to re-rate in the light of this information. Outcomes with a final group median score of ≥ 7, as agreed by 75% of the study group[3], will be considered the draft ‘core clinical outcome measurement set’. This will be discussed by members of the COMPACT consortium to determine the final core set.

Conclusions
Findings from the study will inform the final combined set of patient-reported and clinical outcome measures which will be advocated for use in all CRPS clinical trials.

References

1. Grieve, S., Jones, L., Walsh, N., and McCabe, C., 2016. What outcome measures are commonly used for Complex Regional Pain Syndrome clinical trials? A systematic review of the literature. European Journal of Pain, 20(3), pp.331-340.

2. Grieve, S., Perez, R.S., Birklein, F., Brunner, F., Bruehl, S., Harden, N., Packham, T., Gobeil, F., Haigh, R., Holly, J. and Terkelsen, A., 2017. Recommendations for a first Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT). Pain, 158(6), p.1083.

3. McMillan, S.S., King, M., Tully, M.P., 2016. How to use the Nominal Group and Delphi techniques. International Journal of Clinical Pharmacy, 38(3), pp.655–662.

Citation

Llewellyn, A., Birklein, F., Brunner, F., Goebel, A., Grieve, S., Buckle, L., & McCabe, C. (2019, April). Protocol: An e-Delphi study to define internationally agreed core clinical outcome measures for Complex Regional Pain Syndrome clinical research studies. Poster presented at UWE Centre for Health and Clinical Research Showcase Conference, Bristol, England

Presentation Conference Type Poster
Conference Name UWE Centre for Health and Clinical Research Showcase Conference
Conference Location Bristol, England
Start Date Apr 5, 2019
End Date Apr 5, 2019
Acceptance Date Feb 27, 2019
Publicly Available Date Jun 6, 2019
Peer Reviewed Not Peer Reviewed
Keywords protocol, Delphi, clinical outcome measures, Complex Regional Pain Syndrome
Public URL https://uwe-repository.worktribe.com/output/851676
Additional Information Title of Conference or Conference Proceedings : University of the West of England Centre for Health and Clinical Research Showcase Conference