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All Outputs (128)

Inactivation of Listeria monocytogenes in raw and hot smoked trout fillets by high hydrostatic pressure processing combined with liquid smoke and freezing (2020)
Journal Article
Ekonomou, S. I., Bulut, S., Karatzas, K. A., & Boziaris, I. S. (2020). Inactivation of Listeria monocytogenes in raw and hot smoked trout fillets by high hydrostatic pressure processing combined with liquid smoke and freezing. Innovative Food Science and Emerging Technologies, 64, 102427. https://doi.org/10.1016/j.ifset.2020.102427

High hydrostatic pressure (HHP; 200 MPa for 15 min), liquid smoke (0.50%, v/v) and freezing (−80 °C, overnight) was used to eliminate Listeria monocytogenes in BHI broth, raw and smoked trout. The bactericidal effect of liquid smoke solutions (L9 and... Read More about Inactivation of Listeria monocytogenes in raw and hot smoked trout fillets by high hydrostatic pressure processing combined with liquid smoke and freezing.

Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways (2020)
Thesis
Okoro, G. U. Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1491050

Introduction and aims: Alzheimer’s disease (AD) has for decades been associated with increased accumulation of brain amyloid β peptides (Aβ) and phosphorylated tau. Unfortunately, targeted therapy to Aβ in particular has not been successful resulting... Read More about Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways.

Nitric oxide, other reactive signalling compounds, redox, and reductive stress (2020)
Journal Article
Hancock, J., & Veal, D. (2021). Nitric oxide, other reactive signalling compounds, redox, and reductive stress. Journal of Experimental Botany, 72(3), 819-829. https://doi.org/10.1093/jxb/eraa331

Nitric oxide (NO) and other reactive nitrogen species (RNS) are key signalling molecules in plants, but they do not work in isolation. NO is produced in cells, often increased in response to stress conditions, but many other reactive compounds used i... Read More about Nitric oxide, other reactive signalling compounds, redox, and reductive stress.

Future brief: Pollinators: Importance for nature and human well-being, drivers of decline and the need for monitoring (2020)
Report
Shale, N., Kilfoyle, M., & Jenner, N. (2020). Future brief: Pollinators: Importance for nature and human well-being, drivers of decline and the need for monitoring. Luxembourg: Directorate-General Environment

Pollinators are vital to our wellbeing and the survival of nature. By helping plants reproduce, pollinators support a steady supply of healthy and economically valuable food for humans and prop up entire ecosystems. However, we are at risk of losing... Read More about Future brief: Pollinators: Importance for nature and human well-being, drivers of decline and the need for monitoring.

Breath analysis for detection of viral infection, the current position of the field (2020)
Journal Article
Gould, O., Ratcliffe, N., Król, E., & de Lacy Costello, B. (2020). Breath analysis for detection of viral infection, the current position of the field. Journal of Breath Research, 14(4), https://doi.org/10.1088/1752-7163/ab9c32

The COVID-19 pandemic has highlighted the importance of rapid, cost effective, accurate, and non-invasive testing for viral infections. Volatile compounds (VCs) have been suggested for several decades as fulfilling these criteria. However currently v... Read More about Breath analysis for detection of viral infection, the current position of the field.

Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia (2020)
Thesis
Fombon, I. Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3829730

Introduction and aims: Fenofibrate is the most widely used fibric acid derivative for managing mixed dyslipidaemia, characterised by elevated levels of cholesterol, triglycerides and LDL cholesterol and low levels of HDL cholesterol. Fenofibrate is a... Read More about Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia.

Density functional theory in the prediction of mutagenicity: A perspective (2020)
Journal Article
Townsend, P. A., & Grayson, M. N. (2021). Density functional theory in the prediction of mutagenicity: A perspective. Chemical Research in Toxicology, 34(2), 179-188. https://doi.org/10.1021/acs.chemrestox.0c00113

As a field, computational toxicology is concerned with using in silico models to predict and understand the origins of toxicity. It is fast, relatively inexpensive, and avoids the ethical conundrum of using animals in scientific experimentation. In t... Read More about Density functional theory in the prediction of mutagenicity: A perspective.

An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy (2020)
Journal Article
Russell, G., Rehman, M., LeBaron, T. W., Veal, D., Adukwu, E., & Hancock, J. (2020). An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy. Reactive Oxygen Species, 10(28), 150–165

SARS-CoV-2 is an emerging β-coronavirus that causes COVID-19 disease that manifests primarily as a pulmonary infection that can rapidly progress into severe and acute respiratory distress in susceptible patients. Initial reports of severe pulmonary i... Read More about An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy.

Elements of construction: Minecraft and the periodic table (2020)
Report
Hobbs, L., Bentley, S., Ashby, M., Hartley, J., Rose, R., & Power, C. (2020). Elements of construction: Minecraft and the periodic table. Royal Society of Chemistry

Minecraft is a popular computer game that allows the construction of almost limitless creations, and is used in learning contexts around the world. The widespread appeal and familiarity of the game makes it ideal for engaging children and young peopl... Read More about Elements of construction: Minecraft and the periodic table.

Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer (2020)
Journal Article
Li, L., Hobson, L., Perry, L., Clark, B., Heavey, S., Haider, A., …Ladomery, M. (2020). Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer. British Journal of Cancer, 123, 1024-1032. https://doi.org/10.1038/s41416-020-0951-2

Background: The ERG oncogene, a member of the ETS family of transcription factor encoding genes, is a genetic driver of prostate cancer. It is activated through a fusion with the androgen-responsive TMPRSS2 promoter in 50% of cases. There is therefor... Read More about Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer.

The visual vaccine debate on Twitter: A social network analysis (2020)
Journal Article
Milani, E., Weitkamp, E., & Webb, P. (2020). The visual vaccine debate on Twitter: A social network analysis. Media and Communication, 8(2), 364-375. https://doi.org/10.17645/mac.v8i2.2847

Pro- and anti-vaccination users use social media outlets, such as Twitter, to join conversations about vaccines, disseminate information or misinformation about immunization, and advocate in favour or against vaccinations. These users not only share... Read More about The visual vaccine debate on Twitter: A social network analysis.

Investigations into the design and development of novel screenprinted electrochemical biosensors for sugars (2020)
Thesis
Nicholas, P. Investigations into the design and development of novel screenprinted electrochemical biosensors for sugars. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490862

The aim of the studies described in this thesis was to develop a set of single shot biosensors, for low concentration measures (less the 1 mM) of glucose, sucrose and fructose. In addition, the development of a user friendly potentiostat instrumental... Read More about Investigations into the design and development of novel screenprinted electrochemical biosensors for sugars.

Report on the Working Practices, Motivations and Challenges of those Engaged in Science Communication (2020)
Report
Ridgway, A., Milani, E., Weitkamp, E., & Wilkinson, C. (in press). Report on the Working Practices, Motivations and Challenges of those Engaged in Science Communication. European Commission repository and Zenodo: European Commission

The working practices of those engaged in the communication of science to non-expert audiences has important implications for the relationship between science and society. The research presented here explores these working practices and the motivatio... Read More about Report on the Working Practices, Motivations and Challenges of those Engaged in Science Communication.

Investigating the Links Between Science Communication Actors and Between Actors and their Audiences (2020)
Report
Ridgway, A., Milani, E., Weitkamp, E., & Wilkinson, C. (in press). Investigating the Links Between Science Communication Actors and Between Actors and their Audiences. European Commission repository and Zenodo: European Commission

The audiences reached by those engaged in science communication and the nature of the connections with those audiences is of central importance to the science-society relationship. It determines who is reading, listening and watching information abou... Read More about Investigating the Links Between Science Communication Actors and Between Actors and their Audiences.

Roadmap for naming uncultivated Archaea and Bacteria (2020)
Journal Article
Murray, A. E., Freudenstein, J., Gribaldo, S., Hatzenpichler, R., Hugenholtz, P., Kämpfer, P., …Reysenbach, A. (2020). Roadmap for naming uncultivated Archaea and Bacteria. Nature Microbiology, 5(8), 987-994. https://doi.org/10.1038/s41564-020-0733-x

The assembly of single-amplified genomes (SAGs) and metagenome-assembled genomes (MAGs) has led to a surge in genome-based discoveries of members affiliated with Archaea and Bacteria, bringing with it a need to develop guidelines for nomenclature of... Read More about Roadmap for naming uncultivated Archaea and Bacteria.

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer (2020)
Journal Article
Shafei, M. A., Forshaw, T., Davis, J., Flemban, A., Qualtrough, D., Dean, S., …Conway, M. E. (2020). BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer. Oncotarget, 11, 1971-1987. https://doi.org/10.18632/oncotarget.27607

The cytosolic branched chain aminotransferase (BCATc) protein has been found to be highly expressed in breast cancer subtypes, including triple negative breast cancer (TNBC), compared with normal breast tissue. The catabolism of branched-chain amino... Read More about BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer.