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MicroRNAs and the DNA damage response: How is cell fate determined? (2021)
Journal Article
Visser, H., & Thomas, A. D. (2021). MicroRNAs and the DNA damage response: How is cell fate determined?. DNA Repair, 108, Article 103245. https://doi.org/10.1016/j.dnarep.2021.103245

It is becoming clear that the DNA damage response orchestrates an appropriate response to a given level of DNA damage, whether that is cell cycle arrest and repair, senescence or apoptosis. It is plausible that the alternative regulation of the DNA d... Read More about MicroRNAs and the DNA damage response: How is cell fate determined?.

But my peaks are not Gaussian! Part 3: Physicochemical causes of peak tailing (2021)
Journal Article
Mccalley, D., & Stoll, D. R. (2021). But my peaks are not Gaussian! Part 3: Physicochemical causes of peak tailing. LCGC North America, 39(11), 526–533, 539

Although symmetric peaks with Gaussian shapes are predicted by models of the chromatographic process, "perfect peaks" are not observed often outside of textbooks. Several physico-chemical phenomena can lead to asymmetric peak shapes, including analyt... Read More about But my peaks are not Gaussian! Part 3: Physicochemical causes of peak tailing.

The current status of the world’s primates: Mapping threats to understand priorities for primate conservation (2021)
Journal Article
Fernández, D., Kerhoas, D., Dempsey, A., Billany, J., McCabe, G., & Argirova, E. (2022). The current status of the world’s primates: Mapping threats to understand priorities for primate conservation. International Journal of Primatology, 43, 15–39. https://doi.org/10.1007/s10764-021-00242-2

Over the past decades, primate populations have been declining. Four years ago, >60% of species were listed as threatened. As the rate of loss accelerates and new IUCN assessments are being published, we used IUCN Red List assessments and peer-review... Read More about The current status of the world’s primates: Mapping threats to understand priorities for primate conservation.

Molecular hydrogen: Is this a viable new treatment for plants in the UK? (2021)
Journal Article
Hancock, J. T., LeBaron, T. W., May, J., Thomas, A., & Russell, G. (2021). Molecular hydrogen: Is this a viable new treatment for plants in the UK?. Plants, 10(11), Article 2270

Despite being trialed in other regions of the world, the use of molecular hydrogen (H2) for enhanced plant growth and postharvest storage of crops has yet to be widely accepted in the UK. The evidence continues to grow that treatment of plants and pl... Read More about Molecular hydrogen: Is this a viable new treatment for plants in the UK?.

Real-time detection of volatile metabolites enabling species-level discrimination of bacterial biofilms associated with wound infection (2021)
Journal Article
Slade, E., Thorn, R., Young, A., & Reynolds, D. (2022). Real-time detection of volatile metabolites enabling species-level discrimination of bacterial biofilms associated with wound infection. Journal of Applied Microbiology, 132(3), 1558-1572. https://doi.org/10.1111/jam.15313

Aims: The main aim of this study was to investigate the real-time detection of volatile metabolites for the species-level discrimination of pathogens associated with clinically relevant wound infection, when grown in a collagen wound biofilm model. M... Read More about Real-time detection of volatile metabolites enabling species-level discrimination of bacterial biofilms associated with wound infection.

Paper-based lateral flow device for the sustainable measurement of human plasma fibrinogen in low-resource settings (2021)
Journal Article
Saidykhan, J., Selevic, L., Cinti, S., May, J., & Killard, A. (2021). Paper-based lateral flow device for the sustainable measurement of human plasma fibrinogen in low-resource settings. Analytical Chemistry, 93(41), 14007-14013. https://doi.org/10.1021/acs.analchem.1c03665

Fibrinogen concentration is a major determinant of both clotting and bleeding risk. Clotting and bleeding disorders cause extensive morbidity and mortality, particularly in resource-poor and emergency settings. This is exacerbated by a lack of timely... Read More about Paper-based lateral flow device for the sustainable measurement of human plasma fibrinogen in low-resource settings.

Forensic electrochemical presumptive blood test based on the voltammetric behaviour of methylene blue and whole blood (2021)
Journal Article
Cook, S., & Honeychurch, K. C. (2021). Forensic electrochemical presumptive blood test based on the voltammetric behaviour of methylene blue and whole blood. Analytical Methods, 13(42), 4985-4993. https://doi.org/10.1039/d1ay01358k

The ability to identify the presence of blood residues is important in a number of fields, such as in the forensic and archaeological sciences. A number of tests presently exist; however, these suffer drawbacks, such as difficulties with the interpre... Read More about Forensic electrochemical presumptive blood test based on the voltammetric behaviour of methylene blue and whole blood.

Efficient and scalable generation of human ventral midbrain astrocytes from human-induced pluripotent stem cells (2021)
Journal Article
Crompton, L. A., McComish, S. F., Stathakos, P., Cordero-Llana, O., Lane, J. D., & Caldwell, M. A. (2021). Efficient and scalable generation of human ventral midbrain astrocytes from human-induced pluripotent stem cells. Journal of Visualized Experiments, Article e62095. https://doi.org/10.3791/62095

In Parkinson's disease, progressive dysfunction and degeneration of dopamine neurons in the ventral midbrain cause life-changing symptoms. Neuronal degeneration has diverse causes in Parkinson's, including non-cell autonomous mechanisms mediated by a... Read More about Efficient and scalable generation of human ventral midbrain astrocytes from human-induced pluripotent stem cells.

Application of a solid-phase microextraction-gas chromatography-mass spectrometry/metal oxide sensor system for detection of antibiotic susceptibility in urinary tract infection-causing Escherichia coli – A proof of principle study (2021)
Journal Article
Drabińska, N., Hewett, K., White, P., Avison, M., Persad, R., Ratcliffe, N., & de Lacy Costello, B. (2021). Application of a solid-phase microextraction-gas chromatography-mass spectrometry/metal oxide sensor system for detection of antibiotic susceptibility in urinary tract infection-causing Escherichia coli – A proof of principle study. Advances in Medical Sciences, 67(1), 1-9. https://doi.org/10.1016/j.advms.2021.09.001

Purpose: Antibiotic resistance is widespread throughout the world and represents a serious health concern. There is an urgent need for the development of novel tools for rapidly distinguishing antibiotic resistant bacteria from susceptible strains. P... Read More about Application of a solid-phase microextraction-gas chromatography-mass spectrometry/metal oxide sensor system for detection of antibiotic susceptibility in urinary tract infection-causing Escherichia coli – A proof of principle study.

Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected (2021)
Journal Article
Gynn, L. E., Anderson, E., Robinson, G., Wexler, S. A., Upstill-Goddard, G., Cox, C., & May, J. E. (2021). Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected. Mutagenesis, 36(6), 419-428. https://doi.org/10.1093/mutage/geab033

Tumour microenvironments are hallmarked in many cancer types. In haematological malignancies, bone marrow (BM) mesenchymal stromal cells (MSC) protect malignant cells from drug-induced cytotoxicity. However, less is known about malignant impact on su... Read More about Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected.

Bacterial Viruses Subcommittee and Archaeal Viruses Subcommittee of the ICTV: Update of taxonomy changes in 2021 (2021)
Journal Article
Krupovic, M., Turner, D., Morozova, V., Dyall-Smith, M., Oksanen, H. M., Edwards, R., …Adriaenssens, E. M. (2021). Bacterial Viruses Subcommittee and Archaeal Viruses Subcommittee of the ICTV: Update of taxonomy changes in 2021. Archives of Virology, 166, 3239–3244. https://doi.org/10.1007/s00705-021-05205-9

In this article, we – the Bacterial Viruses Subcommittee and the Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV) – summarise the results of our activities for the period March 2020 – March 2021. We report th... Read More about Bacterial Viruses Subcommittee and Archaeal Viruses Subcommittee of the ICTV: Update of taxonomy changes in 2021.

Molecular hydrogen in agriculture (2021)
Journal Article
Zulfiqar, F., Russell, G., & Hancock, J. T. (2021). Molecular hydrogen in agriculture. Planta, 254(3), Article 56. https://doi.org/10.1007/s00425-021-03706-0

Main conclusion: H2 gas, usually in the form of H2-saturated water, could play a useful role in improving many aspects of plant growth and productivity, including resistance to stress tolerance and improved post-harvest durability. Therefore, molecul... Read More about Molecular hydrogen in agriculture.

Public engagement promotes consumer choice in favour of sustainable palm oil (2021)
Journal Article
Hobbs, L., Phillips, J., Staff, A., Goss, A., Fogg-Rogers, L., & Ellwood, F. (2022). Public engagement promotes consumer choice in favour of sustainable palm oil. Journal of Oil Palm Research, 34(2), 248-260. https://doi.org/10.21894/jopr.2021.0033

Despite the superior productivity, utility and economic benefits of palm oil compared with other oil crops, the palm oil industry often receives negative publicity for its environmental impact and there is widespread confusion over the perception of... Read More about Public engagement promotes consumer choice in favour of sustainable palm oil.

Laboratory in-situ production of autochthonous and allochthonous fluorescent organic matter by freshwater bacteria (2021)
Journal Article
Fox, B. G., Thorn, R. M. S., & Reynolds, D. M. (2021). Laboratory in-situ production of autochthonous and allochthonous fluorescent organic matter by freshwater bacteria. Microorganisms, 9(8), Article 1623. https://doi.org/10.3390/microorganisms9081623

This work investigates the origin and range of fluorescent organic matter (FOM) produced in-situ by environmentally sourced freshwater bacteria. Aquatic FOM is an essential component in global carbon cycling and is generally classified as either auto... Read More about Laboratory in-situ production of autochthonous and allochthonous fluorescent organic matter by freshwater bacteria.

Stimulating fungi Pleurotus ostreatus with hydrocortisone (2021)
Journal Article
Dehshibi, M. M., Chiolerio, A., Nikolaidou, A., Mayne, R., Gandia, A., Ashtari-Majlan, M., & Adamatzky, A. (2021). Stimulating fungi Pleurotus ostreatus with hydrocortisone. ACS Biomaterials Science and Engineering, 7(8), 3718-3726. https://doi.org/10.1021/acsbiomaterials.1c00752

Fungi cells can sense extracellular signals via reception, transduction, and response mechanisms, allowing them to communicate with their host and adapt to their environment. They feature effective regulatory protein expressions that enhance and regu... Read More about Stimulating fungi Pleurotus ostreatus with hydrocortisone.

Amino acid metabolism as a therapeutic target in cancer: A review (2021)
Journal Article
Endicott, M., Jones, M., & Hull, J. (2021). Amino acid metabolism as a therapeutic target in cancer: A review. Amino Acids, 53, 1169–1179. https://doi.org/10.1007/s00726-021-03052-1

Malignant cells often demonstrate a proliferative advantage when compared to non-malignant cells. However, the rapid growth and metabolism required for survival can also highlight vulnerabilities specific to these malignant cells. One such vulnerabil... Read More about Amino acid metabolism as a therapeutic target in cancer: A review.

MicroRNAs, damage levels, and DNA damage response control (2021)
Journal Article
Visser, H., & Thomas, A. D. (2021). MicroRNAs, damage levels, and DNA damage response control. Trends in Genetics, 37(11), 963-965. https://doi.org/10.1016/j.tig.2021.06.018

DNA damage–inducible miRNAs are likely to be functional in the DNA damage response. This response can elicit damage resolution and cell survival or apoptosis. The current, albeit incomplete, picture suggests that miRNAs can affect cell fate via modul... Read More about MicroRNAs, damage levels, and DNA damage response control.

Clean label alternatives in meat products (2021)
Journal Article
Delgado-Pando, G., Ekonomou, S. I., Stratakos, A. C., & Pintado, T. (2021). Clean label alternatives in meat products. Foods, 10(7), 1615. https://doi.org/10.3390/foods10071615

Food authorities have not yet provided a definition for the term “clean label”. However, food producers and consumers frequently use this terminology for food products with few and recognisable ingredients. The meat industry faces important challenge... Read More about Clean label alternatives in meat products.