All Outputs (12)

Quantification of unfractionated heparin in human plasma and whole blood by means of novel fluorogenic anti-FXa assays (2011)
Journal Article
O'Donnell, J. S., Harris, L. F., Castro-López, V., & Killard, A. (2011). Quantification of unfractionated heparin in human plasma and whole blood by means of novel fluorogenic anti-FXa assays. Journal of Pharmaceutical and Biomedical Analysis, 56(5), 992-997. https://doi.org/10.1016/j.jpba.2011.07.025

Novel and sensitive plate-based fluorogenic anti-factor Xa (FXa) assays were investigated to quantify unfractionated heparin (UFH) in human plasma and whole blood within the therapeutic ranges of 0-1.6. U/mL and 0-0.8. U/mL, respectively. Two fluorog... Read More about Quantification of unfractionated heparin in human plasma and whole blood by means of novel fluorogenic anti-FXa assays.

Comparison of a fluorogenic anti-FXa assay with a central laboratory chromogenic anti-FXa assay for measuring LMWH activity in patient plasmas (2011)
Journal Article
O'Donnell, J. S., Harris, L. F., Castro-López, V., Jenkins, P. V., & Killard, A. (2011). Comparison of a fluorogenic anti-FXa assay with a central laboratory chromogenic anti-FXa assay for measuring LMWH activity in patient plasmas. Thrombosis Research, 128(6), 125-129. https://doi.org/10.1016/j.thromres.2011.07.011

Introduction: Low molecular weight heparins (LMWHs) are used worldwide for the treatment and prophylaxis of thromboembolic disorders. Routine laboratory tests are not required due to the predictable pharmacokinetics of LMWHs, with the exception of pr... Read More about Comparison of a fluorogenic anti-FXa assay with a central laboratory chromogenic anti-FXa assay for measuring LMWH activity in patient plasmas.

Comparison of the anticoagulant response of a novel fluorogenic anti-FXa assay with two commercial anti-FXa chromogenic assays (2011)
Journal Article
O'Donnell, J. S., Harris, L. F., O'Brien, A., Castro-López, V., & Killard, A. (2011). Comparison of the anticoagulant response of a novel fluorogenic anti-FXa assay with two commercial anti-FXa chromogenic assays. Thrombosis Research, 128(6), 166-170. https://doi.org/10.1016/j.thromres.2011.08.002

Introduction: Fast and accurate monitoring is crucial in the successful regulation of coagulation therapy. For the treatment of venous thromboembolism, both unfractionated heparin (UFH) and low molecular weight heparins (LMWHs) are commonly administe... Read More about Comparison of the anticoagulant response of a novel fluorogenic anti-FXa assay with two commercial anti-FXa chromogenic assays.

Breath ammonia levels in a normal human population study as determined by photoacoustic laser spectroscopy (2011)
Journal Article
Hibbard, T., & Killard, A. (2011). Breath ammonia levels in a normal human population study as determined by photoacoustic laser spectroscopy. Journal of Breath Research, 5(3), https://doi.org/10.1088/1752-7155/5/3/037101

Photoacoustic laser spectroscopy was used as a technique to measure real-time levels of ammonia in exhaled human breath in a small, locally recruited, normal healthy population (n = 30). This yielded an average level of breath ammonia of 265 ppb, ran... Read More about Breath ammonia levels in a normal human population study as determined by photoacoustic laser spectroscopy.

Chronocoulometric determination of urea in human serum using an inkjet printed biosensor (2011)
Journal Article
Smyth, M. R., Suman, S., O'Reilly, E., Kelly, M., Morrin, A., & Killard, A. (2011). Chronocoulometric determination of urea in human serum using an inkjet printed biosensor. Analytica Chimica Acta, 697(1-2), 98-102. https://doi.org/10.1016/j.aca.2011.04.036

A biosensor for the determination of urea in human serum was fabricated using a combination of inkjet printed polyaniline nanoparticles and inkjet printed urease enzyme deposited sequentially onto screen-printed carbon paste electrodes. Chronocoulome... Read More about Chronocoulometric determination of urea in human serum using an inkjet printed biosensor.

Evaluation of activated partial thromboplastin time (aPTT) reagents for application in biomedical diagnostic device development (2011)
Journal Article
Dudek, M., Harris, L., & Killard, A. (2011). Evaluation of activated partial thromboplastin time (aPTT) reagents for application in biomedical diagnostic device development. International Journal of Laboratory Hematology, 33(3), 272-280. https://doi.org/10.1111/j.1751-553X.2010.01283.x

Introduction: The most commonly used test for monitoring heparin therapy is the activated partial thromboplastin time (aPTT). The response of available aPTT reagents to heparin varies significantly. The aim of this study was to highlight the differen... Read More about Evaluation of activated partial thromboplastin time (aPTT) reagents for application in biomedical diagnostic device development.

Development of a fluorescent method for detecting the onset of coagulation in human plasma on microstructured lateral flow platforms (2011)
Journal Article
Kent, N. J., Dudek, M. M., Gu, P., Fan, Z. H., & Killard, A. (2011). Development of a fluorescent method for detecting the onset of coagulation in human plasma on microstructured lateral flow platforms. Analyst, 136(9), 1816-1825. https://doi.org/10.1039/c0an00907e

Microfluidic devices and microsystems have been used to develop blood coagulation monitoring devices for point of care diagnostic use. However, many of them suffer from inherent variability and imprecision, partly due to the fact that they only detec... Read More about Development of a fluorescent method for detecting the onset of coagulation in human plasma on microstructured lateral flow platforms.

Inkjet printable polyaniline-gold dispersions (2011)
Journal Article
Smyth, M. R., Lenhart, N., Crowley, K., Killard, A., & Morrin, A. (2011). Inkjet printable polyaniline-gold dispersions. Thin Solid Films, 519(13), 4351-4356. https://doi.org/10.1016/j.tsf.2011.02.045

Inkjet printable polyaniline-gold (PANI-Au) hybrid dispersions were synthesised using gold salt as oxidant to simultaneously induce chemical oxidative polymerisation of aniline and reduction of HAuCl4 in bulk aqueous solution. By varying the amount o... Read More about Inkjet printable polyaniline-gold dispersions.

Enhanced electrochemical reduction of hydrogen peroxide on silver paste electrodes modified with surfactant and salt (2011)
Journal Article
Smyth, M. R., Gonzalez-Macia, L., Morrin, A., & Killard, A. (2011). Enhanced electrochemical reduction of hydrogen peroxide on silver paste electrodes modified with surfactant and salt. Electrochimica Acta, 56(11), 4146-4153. https://doi.org/10.1016/j.electacta.2011.01.108

The modification of silver paste electrodes with a combination of dodecylbenzenesulfonic acid and KCl has been shown to lead to significant enhancements of the electrochemical reduction of hydrogen peroxide. The catalytic enhancement was shown to be... Read More about Enhanced electrochemical reduction of hydrogen peroxide on silver paste electrodes modified with surfactant and salt.

Fluorescence-based blood coagulation assay device for measuring activated partial thromboplastin time (2011)
Journal Article
Lindahl, T. L., Gustafsson, K. M., Dudek, M. M., Kent, N., Tomas, L., & Killard, A. (2011). Fluorescence-based blood coagulation assay device for measuring activated partial thromboplastin time. Analytical Chemistry, 83(1), 319-328. https://doi.org/10.1021/ac102436v

The measurement of blood clotting time is important in a range of clinical applications such as assessing coagulation disorders and controlling the effect of various anticoagulant drug therapies. Clotting time tests essentially measure the onset of c... Read More about Fluorescence-based blood coagulation assay device for measuring activated partial thromboplastin time.

Breath ammonia analysis: Clinical application and measurement (2011)
Journal Article
Hibbard, T., & Killard, A. (2011). Breath ammonia analysis: Clinical application and measurement. Critical Reviews in Analytical Chemistry, 41(1), 21-35. https://doi.org/10.1080/10408347.2011.521729

This review covers in detail the complexity of human breath, how the body metabolizes ammonia, clinical conditions which are directly related to the regulation of ammonia concentration, and analysis of current techniques that are capable of detecting... Read More about Breath ammonia analysis: Clinical application and measurement.

Fluorescence-based blood coagulation device for measuring activated partial thromboplastin time (2011)
Journal Article
Dudek, M., Kent, N., Gustafsson, K., Lindahl, T., & Killard, A. (2011). Fluorescence-based blood coagulation device for measuring activated partial thromboplastin time. Analytical Chemistry, 83(1), 319-328. https://doi.org/10.1021/ac102436v

The measurement of blood clotting time is important in a range of clinical applications such as assessing coagulation disorders and controlling the effect of various anticoagulant drug therapies. Clotting time tests essentially measure the onset of c... Read More about Fluorescence-based blood coagulation device for measuring activated partial thromboplastin time.