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Shedding smart light on the effectiveness of chemotherapy: using Raman spectroscopy and machine learning to differentiate the effects of Cytarabine toxicity and crosstalk of leukaemic and bone marrow stromal cells (2021)
Journal Article
Gynn, L., Lamb-Riddell, K., Cox, T., Hansen, M., Conway, M., & May, J. (2021). Shedding smart light on the effectiveness of chemotherapy: using Raman spectroscopy and machine learning to differentiate the effects of Cytarabine toxicity and crosstalk of leukaemic and bone marrow stromal cells. British Journal of Haematology, 193(S1), 46-47

Mesenchymal stromal cells (MSC) protect leukaemic cells from drug-induced toxicity within the bone marrow niche, with increasing evidence of leukaemic impact on supportive stroma. The nucleoside analogue, cytarabine (ara-C), is a front-line agent for... Read More about Shedding smart light on the effectiveness of chemotherapy: using Raman spectroscopy and machine learning to differentiate the effects of Cytarabine toxicity and crosstalk of leukaemic and bone marrow stromal cells.

Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs) (2020)
Journal Article
Fois, M., Cox, T., Ratcliffe, N., & de Lacy Costello, B. (2021). Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs). Sensors and Actuators B: Chemical, 330, https://doi.org/10.1016/j.snb.2020.129264

Heated metal oxide sensors have been widely studied for their ability to give a reversible change in the electrical resistance following the interaction with a volatile compound. Another feature is their inherent cataluminescence (CTL) properties whe... Read More about Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs).

Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications (2020)
Journal Article
Baldwin, F., Craig, T. J., Shiel, A. I., Cox, T., Lee, K., & Mansell, J. P. (2020). Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications. Molecules, 25(7), https://doi.org/10.3390/molecules25071583

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Aseptic loo... Read More about Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications.

Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films (2019)
Patent
Cox, T., Kiely, J., Ratcliffe, N., deLacy Costello, B., & Luxton, R. (2019). Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films

The invention relates to the field of sensors for detecting volatile compounds. The sensor of the present invention for detecting volatile compounds comprises: a film of metal oxide; a heater configured to provide heat energy to the film of metal oxi... Read More about Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films.

Microbial processing and production of aquatic fluorescent organic matter in a model freshwater system (2018)
Journal Article
Fox, B. G., Thorn, R. M., Anesio, A. M., Cox, T., Attridge, J. W., & Reynolds, D. M. (2019). Microbial processing and production of aquatic fluorescent organic matter in a model freshwater system. Water, 11(1), https://doi.org/10.3390/w11010010

© 2018 by the authors. Organic matter (OM) has an essential biogeochemical influence along the hydrological continuum and within aquatic ecosystems. Organic matter derived via microbial processes was investigated within a range of model freshwater sa... Read More about Microbial processing and production of aquatic fluorescent organic matter in a model freshwater system.

Fabrication and evaluation of a micro(bio)sensor array chip for multiple parallel measurements of important cell biomarkers (2014)
Journal Article
Sage, I. C., Drago, G. A., Pemberton, R., Cox, T., Tuffin, R., Griffiths, J., …Hart, J. P. (2014). Fabrication and evaluation of a micro(bio)sensor array chip for multiple parallel measurements of important cell biomarkers. Sensors, 14(11), 20519-20532. https://doi.org/10.3390/s141120519

© 2014 by the authors; licensee MDPI, Basel, Switzerland. This report describes the design and development of an integrated electrochemical cell culture monitoring system, based on enzyme-biosensors and chemical sensors, for monitoring indicators of... Read More about Fabrication and evaluation of a micro(bio)sensor array chip for multiple parallel measurements of important cell biomarkers.

Microfabricated glucose biosensor for culture welloperation (2013)
Journal Article
Hart, J. P., Luxton, R., Xu, J., Griffiths, J., Sage, I., Tuffin, R., …Hart, J. P. (2013). Microfabricated glucose biosensor for culture welloperation. Biosensors and Bioelectronics, 42(1), 668-677. https://doi.org/10.1016/j.bios.2012.11.032

A water-based carbon screen-printing ink formulation, containing the redox mediator cobalt phthalocyanine (CoPC) and the enzyme glucose oxidase (GOx), was investigated for its suitability to fabricate glucose microbiosensors in a 96-well microplate f... Read More about Microfabricated glucose biosensor for culture welloperation.

Synthesis of covalently linked molecular bridges between silicon electrodes in CMOS-based arrays of vertical Si/SiO 2/Si nanogaps (2011)
Journal Article
Sage, I. C., Cox, T. I., Grace, I. M., Lambert, C. J., Williams, A. T., Barnes, S. A., …Sage, I. (2011). Synthesis of covalently linked molecular bridges between silicon electrodes in CMOS-based arrays of vertical Si/SiO 2/Si nanogaps. Angewandte Chemie International Edition, 50(37), 8722-8726. https://doi.org/10.1002/anie.201102791

Silicon nanogaps were bridged in situ by grafting 4-ethynylbenzaldehyde to activate the electrodes and coupling 2,6-diaminoanthra-9,10-quinone to link the coatings. The bridged structures exhibit currents of 11-14 nA at 1 V. The process is reversed b... Read More about Synthesis of covalently linked molecular bridges between silicon electrodes in CMOS-based arrays of vertical Si/SiO 2/Si nanogaps.

Molecular bridging of silicon nanogaps (2010)
Journal Article
Tuffin, R. P., Sage, I. C., Cox, T. I., Bryce, M. R., Grace, I. M., Lambert, C. J., …Ray, S. (2010). Molecular bridging of silicon nanogaps. ACS Nano, 4(12), 7401-7406. https://doi.org/10.1021/nn102460z

The highly doped electrodes of a vertical silicon nanogap device have been bridged by a 5.85 nm long molecular wire, which was synthesized in situ by grafting 4-ethynylbenzaldehyde via C-Si links to the top and bottom electrodes and thereafter by cou... Read More about Molecular bridging of silicon nanogaps.

Preconcentrator device (2008)
Patent
Combes, D., Cox, T., & Sage, I. (2008). Preconcentrator device. WO2009/001065