The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication

Lowndes, S. A.; White, P.; Hooper, C. E.; Lyburn, I. D.; Searle, J.; Darby, M.; Hall, T.; Hall, D.; Morley, A.; White, Paul; Rahman, N. M.; De Winton, E.; Clive, A.; Masani, V.; Arnold, D. T.; Dangoor, A.; Guglani, S.; Jankowska, P.; Lowndes, P; Harvey, J. E.; Braybrooke, J. P.; Maskell, N. A.

Abstract

© 2015 Cancer Research UK. All rights reserved. Background: Robust markers that predict prognosis and detect early treatment response in malignant pleural mesothelioma (MPM) would enhance patient care. Methods: Consecutive patients with MPM who were considered fit for first-line chemotherapy were prospectively recruited. Patients of similar performance status opting for best supportive care were included as a comparator group. Baseline and interval CT, PET-CT and serum markers (mesothelin, fibulin-3 and neutrophil-lymphocyte ratio (NLR)) were obtained, and patients followed up for a minimum 12 months. Findings: Seventy-three patients were recruited (58 chemotherapy/15 comparator arm). Baseline TGV (total glycolytic volume on PET-CT) was an independent predictor of worse overall survival (OS) (P=0.001). Change in interval TGV(baseline/after two cycles of chemotherapy) did not predict OS or chemotherapy response on CT. Baseline NLR

Citation

Lowndes, S. A., White, P., Hooper, C. E., Lyburn, I. D., Searle, J., Darby, M., …Maskell, N. A. (2015). The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication. British Journal of Cancer, 112(7), 1175-1182. https://doi.org/10.1038/bjc.2015.62

• Journal Article Type: Article
• Publication Date: Mar 31, 2015
• Deposit Date: Aug 10, 2015
• Publicly Available Date: Feb 11, 2016
• Journal: British Journal of Cancer
• Print ISSN: 0007-0920
• Electronic ISSN: 1532-1827
• Publisher: Springer Nature [academic journals on nature.com]
• Peer Reviewed: Peer Reviewed
• Volume: 112
• Issue: 7
• Pages: 1175-1182
• DOI: https://doi.org/10.1038/bjc.2015.62
• Keywords: chemotherapy, response and prognostication, SWAMP, observational study
• Public URL: https://uwe-repository.worktribe.com/output/842472
• Publisher URL: http://dx.doi.org/10.1038/bjc.2015.62
• Related Public URLs: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385956/pdf/bjc201562a.pdf