Outputs (81)

Development of a paper-based lateral flow Prothrombin assay (2022)
Journal Article
Saidykhan, J., Pointon, L., Cinti, S., May, J., & Killard, A. (2022). Development of a paper-based lateral flow Prothrombin assay. Analytical Methods, 14, 3718-3726. https://doi.org/10.1039/d2ay00965j

Disorders of haemostasis result in both excessive bleeding and clotting and are a major global cause of morbidity and mortality, particularly in the developing world. A small number of simple tests can be used to screen and monitor for such dysfuncti... Read More about Development of a paper-based lateral flow Prothrombin assay.

Paper-based lateral flow device for the sustainable measurement of human plasma fibrinogen in low-resource settings (2021)
Journal Article
Saidykhan, J., Selevic, L., Cinti, S., May, J., & Killard, A. (2021). Paper-based lateral flow device for the sustainable measurement of human plasma fibrinogen in low-resource settings. Analytical Chemistry, 93(41), 14007-14013. https://doi.org/10.1021/acs.analchem.1c03665

Fibrinogen concentration is a major determinant of both clotting and bleeding risk. Clotting and bleeding disorders cause extensive morbidity and mortality, particularly in resource-poor and emergency settings. This is exacerbated by a lack of timely... Read More about Paper-based lateral flow device for the sustainable measurement of human plasma fibrinogen in low-resource settings.

Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity (2018)
Journal Article
Efremov, V., Lakshmanan, R., Byrne, B., & Killard, A. (2018). Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity. Sensors and Actuators B: Chemical, 266, 472-476. https://doi.org/10.1016/j.snb.2018.03.145

© 2018 Elsevier B.V. It is well-established that alterations in cell morphology are regulated by cell signalling pathways, with the qualitative and quantitative monitoring of these intrinsic processes being of potential diagnostic value. Moreover, th... Read More about Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity.

Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices (2017)
Journal Article
Donaghy, D., Gonzalez-Macia, L., Killard, A., & Raja, M. (2017). Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices. IET Circuits, Devices and Systems, 11(5), 504-511. https://doi.org/10.1049/iet-cds.2016.0500

© The Institution of Engineering and Technology. This paper presents circuit design and simulations of a high gain organic Op-Amp, for use in quantification of real cholesterol, in the range of 1-9 mM. A 7-stage inverter chain is added onto the desig... Read More about Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices.

Disposable sensors (2017)
Journal Article
Killard, A. (2017). Disposable sensors. Current Opinion in Electrochemistry, 3(1), 57-62. https://doi.org/10.1016/j.coelec.2017.06.013

© 2017 Elsevier B.V. Device disposability is a critical feature of electrochemical sensor production, allowing complex measurements to be carried out in a low cost and efficient manner. Disposable sensors are increasing rapidly in their level of soph... Read More about Disposable sensors.

Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics (2017)
Journal Article
Baumann, R. R., Ahmadraji, T., Gonzalez-Macia, L., Ritvonen, T., Willert, A., Ylimaula, S., …Killard, A. (2017). Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics. Analytical Chemistry, 89(14), 7447-7454. https://doi.org/10.1021/acs.analchem.7b01012

© 2017 American Chemical Society. Organic and printed electronics integration has the potential to revolutionize many technologies, including biomedical diagnostics. This work demonstrates the successful integration of multiple printed electronic fu... Read More about Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics.

An electrochemical sensor device for measuring blood ammonia at the point of care (2017)
Journal Article
Brannelly, N. T., & Killard, A. (2017). An electrochemical sensor device for measuring blood ammonia at the point of care. Talanta, 167, 296-301. https://doi.org/10.1016/j.talanta.2017.02.025

The level of ammonia in blood is relevant in a number of medical conditions. While ammonia is a marker of dysfunction, elevated ammonia is itself a serious medical emergency and can lead to significant and permanent neurological impairment if not add... Read More about An electrochemical sensor device for measuring blood ammonia at the point of care.

A Printed and Microfabricated Sensor Device for the Sensitive Low Volume Measurement of Aqueous Ammonia (2016)
Journal Article
Killard, A. J., Brannelly, N. T., Brannelly, N., & Killard, A. (2017). A Printed and Microfabricated Sensor Device for the Sensitive Low Volume Measurement of Aqueous Ammonia. Electroanalysis, 29(1), 162-171. https://doi.org/10.1002/elan.201600556

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The measurement of low concentrations of ammonia in small sample volumes is required in biological, biomedical and environmental measurement applications. However, achieving this without instrumenta... Read More about A Printed and Microfabricated Sensor Device for the Sensitive Low Volume Measurement of Aqueous Ammonia.

Measurement of the viscoelastic properties of blood plasma clot formation in response to tissue factor concentration-dependent activation (2016)
Journal Article
Killard, A. J., Lakshmanan, R. S., Efremov, V., O’Donnell, J. S., & Killard, A. (2016). Measurement of the viscoelastic properties of blood plasma clot formation in response to tissue factor concentration-dependent activation. Analytical and Bioanalytical Chemistry, 408(24), 6581-6588. https://doi.org/10.1007/s00216-016-9689-3

© 2016, The Author(s). The coagulation of blood plasma in response to activation with a range of tissue factor (TF) concentrations was studied with a quartz crystal microbalance (QCM), where frequency and half width at half maximum (bandwidth) values... Read More about Measurement of the viscoelastic properties of blood plasma clot formation in response to tissue factor concentration-dependent activation.

A fully integrated microfluidic device for point of care monitoring of antithrombotics (2016)
Journal Article
Killard, A. J., Harris, L. F., Rainey, P., Lindahl, T. L., & Killard, A. (2016). A fully integrated microfluidic device for point of care monitoring of antithrombotics. Analytical Methods, 8(35), 6500-6505. https://doi.org/10.1039/c6ay01566b

© 2016 The Royal Society of Chemistry. The simplicity and efficiency of point of care diagnostics have revolutionised patient care. Current methods for measuring hypercoagulability often require trained technicians, large blood volumes, and result in... Read More about A fully integrated microfluidic device for point of care monitoring of antithrombotics.