Outputs (80)

Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer (2022)
Journal Article
Boulind, C. E., Gould, O., Costello, B. D. L., Allison, J., White, P., Ewings, P., …Francis, N. K. (2022). Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer. Cancers, 14(9), 2127. https://doi.org/10.3390/cancers14092127

Colorectal symptoms are common but only infrequently represent serious pathology, including colorectal cancer (CRC). A large number of invasive tests are presently performed for reassurance. We investigated the feasibility of urinary volatile organic... Read More about Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer.

Investigation of urinary volatile organic compounds as novel diagnostic and surveillance biomarkers of bladder cancer (2022)
Journal Article
Lett, L., George, M., Slater, R., De Lacy Costello, B., Ratcliffe, N., García-Fiñana, M., …Probert, C. (2022). Investigation of urinary volatile organic compounds as novel diagnostic and surveillance biomarkers of bladder cancer. British Journal of Cancer, 127(2), 329-336. https://doi.org/10.1038/s41416-022-01785-8

Background: The diagnosis and surveillance of urothelial bladder cancer (UBC) require cystoscopy. There is a need for biomarkers to reduce the frequency of cystoscopy in surveillance; urinary volatile organic compound (VOC) analysis could fulfil this... Read More about Investigation of urinary volatile organic compounds as novel diagnostic and surveillance biomarkers of bladder cancer.

Hyphenated mass spectrometry versus real‐time mass spectrometry techniques for the detection of volatile compounds from the human body (2021)
Journal Article
Gould, O., Drabińska, N., Ratcliffe, N., & de Lacy Costello, B. (2021). Hyphenated mass spectrometry versus real‐time mass spectrometry techniques for the detection of volatile compounds from the human body. Molecules, 26(23), Article 7185. https://doi.org/10.3390/molecules26237185

Mass spectrometry (MS) is an analytical technique that can be used for various applications in a number of scientific areas including environmental, security, forensic science, space exploration, agri‐food, and numerous others. MS is also continuing... Read More about Hyphenated mass spectrometry versus real‐time mass spectrometry techniques for the detection of volatile compounds from the human body.

Application of a solid-phase microextraction-gas chromatography-mass spectrometry/metal oxide sensor system for detection of antibiotic susceptibility in urinary tract infection-causing Escherichia coli – A proof of principle study (2021)
Journal Article
Drabińska, N., Hewett, K., White, P., Avison, M., Persad, R., Ratcliffe, N., & de Lacy Costello, B. (2021). Application of a solid-phase microextraction-gas chromatography-mass spectrometry/metal oxide sensor system for detection of antibiotic susceptibility in urinary tract infection-causing Escherichia coli – A proof of principle study. Advances in Medical Sciences, 67(1), 1-9. https://doi.org/10.1016/j.advms.2021.09.001

Purpose: Antibiotic resistance is widespread throughout the world and represents a serious health concern. There is an urgent need for the development of novel tools for rapidly distinguishing antibiotic resistant bacteria from susceptible strains. P... Read More about Application of a solid-phase microextraction-gas chromatography-mass spectrometry/metal oxide sensor system for detection of antibiotic susceptibility in urinary tract infection-causing Escherichia coli – A proof of principle study.

A literature survey of all volatiles from healthy human breath and bodily fluids: The human volatilome (2021)
Journal Article
Drabińska, N., Flynn, C., Ratcliffe, N., Belluomo, I., Myridakis, A., Gould, O., …Costello, B. D. L. (2021). A literature survey of all volatiles from healthy human breath and bodily fluids: The human volatilome. Journal of Breath Research, 15(3), 034001. https://doi.org/10.1088/1752-7163/abf1d0

This paper comprises an updated version of the 2014 review which reported 1846 volatile organic compounds (VOCs) identified from healthy humans. In total over 900 additional VOCs have been reported since the 2014 review and the VOCs from semen have b... Read More about A literature survey of all volatiles from healthy human breath and bodily fluids: The human volatilome.

Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs) (2020)
Journal Article
Fois, M., Cox, T., Ratcliffe, N., & de Lacy Costello, B. (2021). Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs). Sensors and Actuators B: Chemical, 330, Article 129264. https://doi.org/10.1016/j.snb.2020.129264

Heated metal oxide sensors have been widely studied for their ability to give a reversible change in the electrical resistance following the interaction with a volatile compound. Another feature is their inherent cataluminescence (CTL) properties whe... Read More about Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs).

Towards the identification of antibiotic-resistant bacteria causing urinary tract infections using volatile organic compounds analysis—a pilot study (2020)
Journal Article
Hewett, K., Drabinska, N., White, P., Avison, M., Persad, R., Ratcliffe, N., & de Lacy Costello, B. (2020). Towards the identification of antibiotic-resistant bacteria causing urinary tract infections using volatile organic compounds analysis—a pilot study. Antibiotics, 9(11), 797. https://doi.org/10.3390/antibiotics9110797

Antibiotic resistance is an unprecedented threat to modern medicine. The analysis of volatile organic compounds (VOCs) from bacteria potentially offers a rapid way to determine antibiotic susceptibility in bacteria. This study aimed to find the optim... Read More about Towards the identification of antibiotic-resistant bacteria causing urinary tract infections using volatile organic compounds analysis—a pilot study.

Breath analysis for detection of viral infection, the current position of the field (2020)
Journal Article
Gould, O., Ratcliffe, N., Król, E., & de Lacy Costello, B. (2020). Breath analysis for detection of viral infection, the current position of the field. Journal of Breath Research, 14(4), https://doi.org/10.1088/1752-7163/ab9c32

The COVID-19 pandemic has highlighted the importance of rapid, cost effective, accurate, and non-invasive testing for viral infections. Volatile compounds (VCs) have been suggested for several decades as fulfilling these criteria. However currently v... Read More about Breath analysis for detection of viral infection, the current position of the field.

From fast identification to resistance testing: Volatile compound profiling as a novel diagnostic tool for detection of antibiotic susceptibility (2019)
Journal Article
Smart, A., de Lacy Costello, B., Ratcliffe, N., Drabinksa, N., & Hewett, K. (2019). From fast identification to resistance testing: Volatile compound profiling as a novel diagnostic tool for detection of antibiotic susceptibility. Trends in Analytical Chemistry, 115, 1-12. https://doi.org/10.1016/j.trac.2019.03.019

Widespread use of antibiotics has led to the development of antibiotic resistance in many pathogenic bacteria. If effective methods of alleviating this crisis are not applied, a return to high mortality and morbidity of the pre-antibiotic era could o... Read More about From fast identification to resistance testing: Volatile compound profiling as a novel diagnostic tool for detection of antibiotic susceptibility.

Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles (2019)
Journal Article
Smart, A., de Lacy Costello, B., White, P., Avison, M., Batty, C., Turner, C., …Ratcliffe, N. (2019). Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles. Journal of Pharmaceutical and Biomedical Analysis, 167, 59-65. https://doi.org/10.1016/j.jpba.2019.01.044

© 2019 Elsevier B.V. Antibiotic resistance is set to be an unprecedented threat to modern medicine. ‘Sniffing’ bacteria potentially offers a rapid way to determine susceptibility. A successful proof-of-principle study is described, using thermal deso... Read More about Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles.