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Outputs (153)

The role of redox mechanisms in cell signalling (2009)
Journal Article
Hancock, J. T. (2009). The role of redox mechanisms in cell signalling. Molecular Biotechnology, 43(2), 162-166. https://doi.org/10.1007/s12033-009-9189-1

Functioning and efficient cell signalling is vital for the survival of cells. Over the years various components have been identified and recognised as crucial for the transduction of signals in cells. Many of the mechanisms allow for a relatively rap... Read More about The role of redox mechanisms in cell signalling.

Bacterial Evolution by Genomic Island Transfer Occurs via DNA Transformation In Planta (2009)
Journal Article
Godfrey, S. A. C., Lovell, H. C., Mansfield, J. W., Jackson, R. W., Hancock, J. T., & Arnold, D. L. (2009). Bacterial Evolution by Genomic Island Transfer Occurs via DNA Transformation In Planta. Current Biology, 19(18), 1586-1590. https://doi.org/10.1016/j.cub.2009.08.018

Our understanding of the evolution of microbial pathogens has been advanced by the discovery of "islands" of DNA that differ from core genomes and contain determinants of virulence [1, 2]. The acquisition of genomic islands (GIs) by horizontal gene t... Read More about Bacterial Evolution by Genomic Island Transfer Occurs via DNA Transformation In Planta.

Reactive oxygen species, nitric oxide and signal crosstalk (2009)
Book Chapter
Neill, S., Hancock, J. T., & Wilson, I. D. (2009). Reactive oxygen species, nitric oxide and signal crosstalk. In K. Yoshioka, & K. Shinozaki (Eds.), Signal Crosstalk in Plant Stress Responses (136-160). Iowa: Wiley-Blackwell

S-Nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and S-thiolation (2009)
Journal Article
Coles, S. J., Easton, P., Sharrod, H., Hutson, S. M., Hancock, J. T., Patel, V., & Conway, M. E. (2009). S-Nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and S-thiolation. Biochemistry, 48(3), 645-656. https://doi.org/10.1021/bi801805h

Specific proteins with reactive thiol(ate) groups are susceptible to nitric oxide (NO) modification, which can result in S-nitrosation, S-thiolation, or disulfide bond formation. In the present study the effect of NO modification on the functionality... Read More about S-Nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and S-thiolation.

S-nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and s-thiolation (2009)
Journal Article
Coles, S. J., Easton, P., Sharrod, H., Hutson, S. M., Hancock, J. T., Patel, V. B., & Conway, M. E. (2009). S-nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and s-thiolation. Biochemistry, 48(3), 645-656. https://doi.org/10.1021/bi801805h

Specific proteins with reactive thiol(ate) groups are susceptible to nitric oxide (NO) modification, which can result in S-nitrosation, S-thiolation, or disulfide bond formation. In the present study the effect of NO modification on the functionality... Read More about S-nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and s-thiolation.

Pollen generates nitric oxide and nitrite: a possible link to pollen-induced allergic responses (2009)
Journal Article
Bright, J., Hiscock, S. J., James, P. E., & Hancock, J. T. (2009). Pollen generates nitric oxide and nitrite: a possible link to pollen-induced allergic responses. Plant Physiology and Biochemistry, 47(1), 49-55. https://doi.org/10.1016/j.plaphy.2008.09.005

Reactive nitrogen species (RNS), such as nitric oxide (NO), are ubiquitous and diverse signalling molecules involved in a wide range of physiological and pathophysiological processes in both animals and plants. Nitrite, a metabolite of NO turnover, h... Read More about Pollen generates nitric oxide and nitrite: a possible link to pollen-induced allergic responses.

Tools to investigate reaction oxygen species-sensitive signaling proteins (2009)
Book Chapter
Desikan, R., Neill, S., Slinn, J., & Hancock, J. T. (2009). Tools to investigate reaction oxygen species-sensitive signaling proteins. In J. T. Hancock (Ed.), Redox-Mediated Signal Transduction (84-96). Humana Press. https://doi.org/10.1007/978-1-59745-129-1_7

The thiols groups of cysteine residues on proteins are attractive oxidative targets for modification by reactive oxygen species, such as hydrogen peroxide (H2O2). Such modification can lead to important cellular signaling processes that ultimately re... Read More about Tools to investigate reaction oxygen species-sensitive signaling proteins.