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The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells (2010)
Journal Article
Patsos, H. A., Greenhough, A., Hicks, D. J., Al Kharusi, M., Collard, T. J., Lane, J. D., …Williams, A. C. (2010). The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. International Journal of Oncology, 37(1), 187-193. https://doi.org/10.3892/ijo_00000666

Despite recent advances in understanding colorectal tumour biology, there is still a need to improve the 5-year survival rate of patients with colorectal cancer as approximately 40% of patients presenting with advanced disease will remain resistant t... Read More about The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.

Amperometric lactate biosensor for flow injection analysis based on a screen-printed carbon electrode containing Meldola's Blue-Reinecke salt, coated with lactate dehydrogenase and NAD+ (2010)
Journal Article
Piano, M., Serban, S., Pittson, R., Drago, G. A., & Hart, J. P. (2010). Amperometric lactate biosensor for flow injection analysis based on a screen-printed carbon electrode containing Meldola's Blue-Reinecke salt, coated with lactate dehydrogenase and NAD+. Talanta, 82(1), 34-37. https://doi.org/10.1016/j.talanta.2010.03.051

A biosensor for the measurement of lactate in serum has been developed, which is based on a screen-printed carbon electrode, modified with Meldola's Blue-Reinecke Salt (MBRS-SPCE), coated with the enzyme lactate dehydrogenase NAD+ dependent (from Por... Read More about Amperometric lactate biosensor for flow injection analysis based on a screen-printed carbon electrode containing Meldola's Blue-Reinecke salt, coated with lactate dehydrogenase and NAD+.

Investigation of the semiochemicals of confused flour beetle Tribolium confusum Jaquelin du Val and grain weevil Sitophilus granarius (L.) in stored wheat grain and flour (2010)
Presentation / Conference
Abuelnnor, N., Jones, P., Ratcliffe, N. M., de Lacy Costello, B., & Spencer-Phillips, P. T. (2010, June). Investigation of the semiochemicals of confused flour beetle Tribolium confusum Jaquelin du Val and grain weevil Sitophilus granarius (L.) in stored wheat grain and flour. Paper presented at 10th International Working Conference on Stored Product Protection, Estoril Congress Center, Portugal

This investigation sets out to identify specific volatile compounds from both flour infested with the confused flour beetle, Tribolium confusum and wheat grain infested with the grain weevil, Sitophilus granarius. These volatiles could help to aid th... Read More about Investigation of the semiochemicals of confused flour beetle Tribolium confusum Jaquelin du Val and grain weevil Sitophilus granarius (L.) in stored wheat grain and flour.

Cyclic voltammetric behaviour of Rohypnol, Ativan and Valium and its exploitation for their determination in serum using a novel method involving liquid chromatography-dual electrode detection (2010)
Presentation / Conference
Honeychurch, K. C., Chong, A., Elamin, K., & Hart, J. P. (2010, June). Cyclic voltammetric behaviour of Rohypnol, Ativan and Valium and its exploitation for their determination in serum using a novel method involving liquid chromatography-dual electrode detection. Paper presented at Great Western Electrochemistry Meeting 2010, University of Bath, Bath, UK

Gas sensor (2010)
Patent
Ratcliffe, N. M., de Lacy Costello, B., & Richards, W. (2010). Gas sensor. EP20080804338

A method of detection of a volatile compound in a gaseous atmosphere comprises irradiating a semiconducting metal oxide material with ultraviolet light, exposing the irradiated material to the gaseous atmosphere and determining the presence of any vo... Read More about Gas sensor.

American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (2010)
Journal Article
progesterone receptors in breast cancer. Archives of Pathology and Laboratory Medicine, 134(6), 907-922

Purpose: To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers. Methods: The American... Read More about American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.

Magnetizable antibody-like proteins (2010)
Journal Article
Dehal, P. K., Livingston, C. F., Dunn, C. G., Buick, R., Luxton, R. W., & Pritchard, D. J. (2010). Magnetizable antibody-like proteins. Biotechnology Journal, 5(6), 596-604. https://doi.org/10.1002/biot.200900273

Use of paramagnetic particles to isolate molecules or cells from complex media is well established. Typically, particles are manufactured and coated with a biological molecule that confers specific biorecognition. Incubation of particles with sample... Read More about Magnetizable antibody-like proteins.

American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (2010)
Journal Article
Wittliff, J. L., Sweep, F. C., Osborne, C. K., Mangu, P. B., Hicks, D. G., Goldstein, N. S., …Wolff, A. C. (2010). American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Journal of Clinical Oncology, 28(16), 2784-2795. https://doi.org/10.1200/JCO.2009.25.6529

Purpose: To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers. Methods: The American Socie... Read More about American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.

Kinetic behaviour of WT 1's zinc finger domain in binding to the alpha-actinin-1 mRNA (2010)
Journal Article
Nurmemmedov, E., Yengo, R. K., Ladomery, M., & Thunnissen, M. M. (2010). Kinetic behaviour of WT 1's zinc finger domain in binding to the alpha-actinin-1 mRNA. Archives of Biochemistry and Biophysics, 497(1-2), 21-27. https://doi.org/10.1016/j.abb.2010.02.013

The zinc finger transcription factor Wilms tumour protein (WT 1) is known for its essential involvement in the development of the genitourinary system as well as of other organs and tissues. WT 1 is capable of selectively binding either DNA or mRNA t... Read More about Kinetic behaviour of WT 1's zinc finger domain in binding to the alpha-actinin-1 mRNA.

Effects of flow-rate, inoculum and time on the internal resistance of microbial fuel cells (2010)
Journal Article
Ieropoulos, I., Winfield, J., & Greenman, J. (2010). Effects of flow-rate, inoculum and time on the internal resistance of microbial fuel cells. Bioresource Technology, 101(10), 3520-3525. https://doi.org/10.1016/j.biortech.2009.12.108

To process large volumes of wastewater, microbial fuel cells (MFCs) would require anodophilic bacteria preferably operating at high flow-rates. The effect of flow-rate on different microbial consortia was examined during anodic biofilm development, u... Read More about Effects of flow-rate, inoculum and time on the internal resistance of microbial fuel cells.

W1908 diagnostic potential of volatile organic compounds in inflammatory bowel disease (2010)
Journal Article
Ahmed, I., Probert, C., Ratcliffe, N. M., & Greenwood, R. (2010). W1908 diagnostic potential of volatile organic compounds in inflammatory bowel disease

Introduction: Crohn's disease (CD) and ulcerative colitis (UC) are diagnosed using invasive investigations which patients find unpleasant. Non-invasive modalities to asses the clinical course of the disease are yet to be adopted. Volatile organic com... Read More about W1908 diagnostic potential of volatile organic compounds in inflammatory bowel disease.

Study of the selectivity, retention mechanisms and performance of alternative silica-based stationary phases for separation of ionised solutes in hydrophilic interaction chromatography (2010)
Journal Article
McCalley, D. V. (2010). Study of the selectivity, retention mechanisms and performance of alternative silica-based stationary phases for separation of ionised solutes in hydrophilic interaction chromatography. Journal of Chromatography A, 1217(20), 3408-3417. https://doi.org/10.1016/j.chroma.2010.03.011

The separation of a mixture of neutral, strongly acidic and strongly basic compounds was studied in hydrophilic interaction chromatography using a bare silica phase, and bonded silica phases with diol, zwitterionic, amide and hydrophilic/hydrophobic... Read More about Study of the selectivity, retention mechanisms and performance of alternative silica-based stationary phases for separation of ionised solutes in hydrophilic interaction chromatography.

An in vitro model of chemotherapeutic damage to mesenchymal stem cells (2010)
Presentation / Conference
May, J. E., Xu, J., Morse, R., Avent, N. D., Cox, C., Wexler, S. A., & Donaldson, C. (2010, April). An in vitro model of chemotherapeutic damage to mesenchymal stem cells. Poster presented at 4th UK Mesenchymal Stem Cell Meeting, Leeds University, UK

The Effect of Phosphite Treatments on the Growth and Disease Susceptibility of Agrostis stolonifera L. (2010)
Presentation / Conference
Dempsey, J. J., & Owen, A. A. G. (2010, April). The Effect of Phosphite Treatments on the Growth and Disease Susceptibility of Agrostis stolonifera L. Paper presented at 2nd European Turfgrass Society Conference, Angers, France

Nutrition and disease control are two essential areas of fine turf management. The application of phosphite (H3PO3) to turf surfaces has been suggested as a means to reduce susceptibility to fungal diseases and to improve turf quality. The aim of t... Read More about The Effect of Phosphite Treatments on the Growth and Disease Susceptibility of Agrostis stolonifera L..

Modelling the effects of pH on tongue biofilm using a sorbarod biofilm perfusion system (2010)
Journal Article
Taylor, B., & Greenman, J. (2010). Modelling the effects of pH on tongue biofilm using a sorbarod biofilm perfusion system. Journal of Breath Research, 4(1), 017107. https://doi.org/10.1088/1752-7155/4/1/017107

The pH of the tongue biofilm is likely to influence microbial composition and ecology with consequent effects on the metabolic activities and generation of volatile sulfur compounds (VSC) and other malodour gasses. The aim of this study was to identi... Read More about Modelling the effects of pH on tongue biofilm using a sorbarod biofilm perfusion system.

Improved energy output levels from small-scale Microbial Fuel Cells (2010)
Journal Article
Ieropoulos, I., Greenman, J., & Melhuish, C. (2010). Improved energy output levels from small-scale Microbial Fuel Cells. Bioelectrochemistry, 78(1), 44-50. https://doi.org/10.1016/j.bioelechem.2009.05.009

This study reports on the findings from the investigation into small-scale (6.25mL) MFCs, connected together as a network of multiple units. The MFCs contained unmodified (no catalyst) carbon fibre electrodes and for initial and later experiments, a... Read More about Improved energy output levels from small-scale Microbial Fuel Cells.

Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine- modified screen-printed carbon electrode and its application in pharmaceutical and food analysis (2010)
Journal Article
Honeychurch, K. C., Gilbert, L., & Hart, J. P. (2010). Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine- modified screen-printed carbon electrode and its application in pharmaceutical and food analysis. Analytical and Bioanalytical Chemistry, 396(8), 3103-3111. https://doi.org/10.1007/s00216-010-3534-x

Cobalt phthalocyanine-modified screen-printed carbon electrodes (CoPC-SPCEs) have been investigated as disposable sensors for the measurement of citric acid. The analyte was found to undergo an electrocatalytic oxidation process involving the Co2+/Co... Read More about Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine- modified screen-printed carbon electrode and its application in pharmaceutical and food analysis.

Short-term effect of deep shade and enhanced nitrogen supply on Sphagnum capillifolium morphophysiology (2010)
Journal Article
Bonnett, S. A., Ostle, N., & Freeman, C. (2010). Short-term effect of deep shade and enhanced nitrogen supply on Sphagnum capillifolium morphophysiology. Plant Ecology, 207(2), 347-358. https://doi.org/10.1007/s11258-009-9678-0

Sphagnum capillifolium mesocosms collected from an ombrotrophic blanket bog were subjected to controlled photon flux densities (control and shaded) and nitrogen (low and high) treatments between November 2003 and August 2004. Shading significantly re... Read More about Short-term effect of deep shade and enhanced nitrogen supply on Sphagnum capillifolium morphophysiology.

The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells (2010)
Journal Article
Greenhough, A., Wallam, C. A., Hicks, D. J., Moorghen, M., Williams, A. C., & Paraskeva, C. (2010). The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells. Oncogene, 29(23), 3398-3410. https://doi.org/10.1038/onc.2010.94

Overexpression of cyclooxygenase-2 (COX-2) and elevated levels of its enzymatic product prostaglandin E2 (PGE 2) occur in the majority of colorectal cancers and have important roles in colorectal tumorigenesis. However, despite the established prosur... Read More about The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells.