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How hydrogen (H2) can support food security: From farm to fork (2024)
Journal Article
Russell, G., Nenov, A., & Hancock, J. T. (2024). How hydrogen (H2) can support food security: From farm to fork. Applied Sciences, 14(7), 2877. https://doi.org/10.3390/app14072877

Molecular hydrogen (H2) is a low-molecular-weight, non-polar and electrochemically neutral substance that acts as an effective antioxidant and cytoprotective agent, with research into the effects of H2 incorporation into the food chain, at various st... Read More about How hydrogen (H2) can support food security: From farm to fork.

An interplay of gases: oxygen and hydrogen in biological systems (2024)
Journal Article
Russell, G., May, J., & Hancock, J. T. (2024). An interplay of gases: oxygen and hydrogen in biological systems. Oxygen, 4(1), 37-52. https://doi.org/10.3390/oxygen4010003

Produced by photosynthesis, oxygen (O2) is a fundamentally important gas in biological systems, playing roles as a terminal electron receptor in respiration and in host defence through the creation of reactive oxygen species (ROS). Hydrogen (H2) play... Read More about An interplay of gases: oxygen and hydrogen in biological systems.

Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences (2023)
Journal Article
Zulfiqar, F., Moosa, A., Darras, A., Nafees, M., Ashraf, M., Al-Ashkar, I., …Hancock, J. T. (2024). Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences. Journal of Plant Growth Regulation, 43, 1153–1165. https://doi.org/10.1007/s00344-023-11173-y

Gladiolus is a well-known bulbous plant producing impressive cut spikes. Hydrogen sulfide and nitric oxide are vital signaling molecules for the proper functioning of plant metabolism. Preharvest applications of these molecules to crops have gained a... Read More about Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences.

The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells (2023)
Journal Article
Russell, G., Thomas, A. D., Nenov, A., Mannings, G., & Hancock, J. T. (2023). The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells. Hydrogen, 4(4), 746-759. https://doi.org/10.3390/hydrogen4040047

Cancer is a leading cause of mortality worldwide. B-cells are a keystone of the adaptive immune response and are essential for the presentation of tumor-associated antigens to various types of T-cells. Approximately 1.5% of global cancer cases, inclu... Read More about The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells.

Nanotechnology improves disease resistance in plants for food security: Applications and challenges (2023)
Journal Article
Munir, N., Gulzar, W., Abideen, Z., Hancock, J. T., El-Keblawy, A., & Radicetti, E. (2023). Nanotechnology improves disease resistance in plants for food security: Applications and challenges. Biocatalysis and Agricultural Biotechnology, 51, Article 102781

Green synthesis of nano-fertilizers is emerging as a potential strategy and could play a crucial role in disease mitigation, diagnosis, or suppression. Different nanoscale devices (nanoparticles, NPs), biosensors, nano-diagnostic kits, nanofabricatio... Read More about Nanotechnology improves disease resistance in plants for food security: Applications and challenges.

Are protein cavities and pockets commonly used by redox active signalling molecules? (2023)
Journal Article
Hancock, J. T. (2023). Are protein cavities and pockets commonly used by redox active signalling molecules?. Plants, 12(14), 2594. https://doi.org/10.3390/plants12142594

It has been well known for a long time that inert gases, such as xenon (Xe), have significant biological effects. As these atoms are extremely unlikely to partake in direct chemical reactions with biomolecules such as proteins, lipids, and nucleic ac... Read More about Are protein cavities and pockets commonly used by redox active signalling molecules?.

The on/off history of hydrogen in medicine: Will the interest persist this time around? (2023)
Journal Article
LeBaron, T. W., Ohno, K., & Hancock, J. T. (2023). The on/off history of hydrogen in medicine: Will the interest persist this time around?. Oxygen, 3(1), 143-162. https://doi.org/10.3390/oxygen3010011

Over 2000 publications including more than 100 human studies seem to indicate that humans have only recently benefited from or known about the medical effects of H2 within the past 15 years. However, we have unknowingly benefited from H2 since the da... Read More about The on/off history of hydrogen in medicine: Will the interest persist this time around?.

The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy (2023)
Journal Article
Hancock, J. T., & LeBaron, T. W. (2023). The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy. Oxygen, 3(1), 102-119. https://doi.org/10.3390/oxygen3010008

In 2007 a paper in Nature Medicine sparked a new wave of interest in the use of molecular hydrogen (H2) for medical treatments. Since then there has been a flurry of papers looking at a range of medical aspects, from neurodegenerative disease to spor... Read More about The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy.

Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily (2022)
Journal Article
Hancock, J. T., Russell, G., Craig, T. J., May, J., Morse, H. R., & Stamler, J. S. (2022). Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily. Oxygen, 2(4), 578-590. https://doi.org/10.3390/oxygen2040038

Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe),... Read More about Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily.

Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry (2022)
Journal Article
Hancock, J. T., Russell, G., & Stratakos, A. (2022). Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry. Applied Sciences, 12(20), Article 10448. https://doi.org/10.3390/app122010448

Featured Application: It is proposed here that the use of molecular hydrogen should be considered more widely for the treatment of post-harvest fruits, vegetables and flowers. This can be applied as a gas, or in solution, and costs associated with it... Read More about Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry.

The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19 (2022)
Journal Article
Russell, G., Thomas, A., Nenov, A., & Hancock, J. (2022). The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19. Medical Research Archives, 10(9), https://doi.org/10.18103/mra.v10i9.3036

Coronavirus Infectious Disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) that emerged as a novel pathogen of global concern in the latter stages of 2019. COVID-19 is a highly contagio... Read More about The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19.

Chemical priming enhances plant tolerance to salt stress (2022)
Journal Article
Zulfiqar, F., Nafees, M., Chen, J., Darras, A., Ferrante, A., Hancock, J. T., …Siddique, K. H. (2022). Chemical priming enhances plant tolerance to salt stress. Frontiers in Plant Science, 13, 946922. https://doi.org/10.3389/fpls.2022.946922

Salt stress severely limits the productivity of crop plants worldwide and its detrimental effects are aggravated by climate change. Due to a significant world population growth, agriculture has expanded to marginal and salinized regions, which usuall... Read More about Chemical priming enhances plant tolerance to salt stress.

Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1 (2022)
Journal Article
Ying, S., Yang, W., Li, P., Hu, Y., Lu, S., Zhou, Y., …Hu, X. (2022). Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1. EMBO Reports, Article e54371. https://doi.org/10.15252/embr.202154371

Light and ambient high temperature (HT) have opposite effects on seed germination. Light induces seed germination through activating the photoreceptor phytochrome B (phyB), resulting in the stabilization of the transcription factor HFR1, which in tur... Read More about Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1.

Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2? (2022)
Journal Article
Hancock, J. T., Veal, D., Craig, T. J., & Rouse, R. C. (2022). Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2?. Reactive Oxygen Species, 12, c14–c29. https://doi.org/10.20455/ros.2022.c805

Infection with the SARS-Cov-2 virus causes COVID-19 in humans, and is the cause of the pandemic around the world in 2020 and on. However, some animals have been found to be susceptible to the virus too. This has included the non-human primates, dogs,... Read More about Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2?.

Molecular hydrogen as medicine: An assessment of administration methods (2021)
Journal Article
Russell, G., Nenov, A., Kisher, H., & Hancock, J. T. (2021). Molecular hydrogen as medicine: An assessment of administration methods. Hydrogen, 2(4), 444-460. https://doi.org/10.3390/hydrogen2040025

Since the late 18th century, molecular hydrogen (H2) has been shown to be well tolerated, firstly in animals, and then in humans. However, although research into the beneficial effects of molecular hydrogen in both plant and mammalian physiology is g... Read More about Molecular hydrogen as medicine: An assessment of administration methods.

Molecular hydrogen in agriculture (2021)
Journal Article
Zulfiqar, F., Russell, G., & Hancock, J. T. (2021). Molecular hydrogen in agriculture. Planta, 254(3), Article 56. https://doi.org/10.1007/s00425-021-03706-0

Main conclusion: H2 gas, usually in the form of H2-saturated water, could play a useful role in improving many aspects of plant growth and productivity, including resistance to stress tolerance and improved post-harvest durability. Therefore, molecul... Read More about Molecular hydrogen in agriculture.

Oxygen is instrumental for biological signalling: An overview (2021)
Journal Article
Hancock, J. (2021). Oxygen is instrumental for biological signalling: An overview. Oxygen, 1(1), 3-15. https://doi.org/10.3390/oxygen1010002

Control of cellular function is extremely complex, being reliant on a wide range of components. Several of these are small oxygen-based molecules. Although reactive compounds containing oxygen are usually harmful to cells when accumulated to relative... Read More about Oxygen is instrumental for biological signalling: An overview.

Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases (2021)
Journal Article
Russell, G., Nenov, A., & Hancock, J. (2021). Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases. European Medical Journal, May 2021, https://doi.org/10.33590/emj/21-00027

Oxy-hydrogen gas (HHO) is a gaseous mixture of molecular hydrogen (H2) and molecular oxygen (O2) that is generated by the electrolysis of water and delivered in a 2:1 ratio (66% and 33%, respectively) through the use of non-invasive inhalation device... Read More about Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases.