The on/off history of hydrogen in medicine: Will the interest persist this time around?

LeBaron, Tyler W.; Ohno, Kinji; Hancock, John T.

Abstract

Over 2000 publications including more than 100 human studies seem to indicate that humans have only recently benefited from or known about the medical effects of H2 within the past 15 years. However, we have unknowingly benefited from H2 since the dawn of time from H2-producing bacteria to the use of naturally occurring hydrogen-rich waters. Moreover, the first writings on the therapeutic effects of H2 date to around 1793. Since then, papers appeared sporadically in the lit-erature every few decades but never exploded until Ohsawa et al. again demonstrated hydrogen’s therapeutic effects in 2007. This landmark paper appears to have been the spark that ignited the medical interest in hydrogen. Although H2 was used in the 1880s to locate intestinal perforations, in the 1940s in deep sea diving, and in the 1960s to measure blood flow, H2 was largely viewed as biologically inert. This review highlights the history of hydrogen in the genesis/evolution of life and its medicinal and non-medicinal use in humans. Although hydrogen medicine has a long and erratic history, perhaps future history will show that, this time around, these 15 years of ignited interest resulted in a self-sustaining explosion of its unique medical effects.

• Journal Article Type: Review
• Acceptance Date: Feb 27, 2023
• Online Publication Date: Mar 14, 2023
• Publication Date: Mar 14, 2023
• Deposit Date: Feb 27, 2023
• Publicly Available Date: Mar 31, 2023
• Journal: Oxygen
• Electronic ISSN: 2673-9801
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 1
• Pages: 143-162
• DOI: https://doi.org/10.3390/oxygen3010011
• Keywords: Antioxidants, COVID-19; Diving, Hydrogen-rich water; Hydroxyl radicals; Molecular hydrogen, Neurodegenerative diseases
• Public URL: https://uwe-repository.worktribe.com/output/10485503
• Publisher URL: https://www.mdpi.com/journal/oxygen