Skip to main content

Research Repository

Advanced Search

Early determinants of mortality in hospitalized COVID-19 patients in the Eastern Province of Saudi Arabia (2022)
Journal Article
Ansari, K. A., Alwazzeh, M. J., Alkuwaiti, F. A., Farooqi, F. A., Al Khathlan, N., Almutawah, H., …Alkuwaiti, E. (2022). Early determinants of mortality in hospitalized COVID-19 patients in the Eastern Province of Saudi Arabia. International Journal of General Medicine, 15(15), 1689-1701. https://doi.org/10.2147/ijgm.s349598

Purpose: This study investigated the clinical determinants of mortality in hospitalized patients infected with COVID-19. Patients and Methods: A retrospective multicenter large cohort of COVID-19 patients hospitalized between March 2020 and February... Read More about Early determinants of mortality in hospitalized COVID-19 patients in the Eastern Province of Saudi Arabia.

Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected (2021)
Journal Article
Gynn, L. E., Anderson, E., Robinson, G., Wexler, S. A., Upstill-Goddard, G., Cox, C., & May, J. E. (2021). Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected. Mutagenesis, 36(6), 419-428. https://doi.org/10.1093/mutage/geab033

Tumour microenvironments are hallmarked in many cancer types. In haematological malignancies, bone marrow (BM) mesenchymal stromal cells (MSC) protect malignant cells from drug-induced cytotoxicity. However, less is known about malignant impact on su... Read More about Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected.

Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects (2021)
Thesis
Ude, A. Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6971684

Advances in modern chemotherapeutic regimens have led to an increase in the overall survival of leukaemia patients in recent years. However, haematopoietic stem cell transplantation (HSCT) remains the curative option for these patients. In HSCT, high... Read More about Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects.

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer (2020)
Journal Article
Nounu, A., Greenhough, A., Heesom, K. J., Richmond, R. C., Zheng, J., Weinstein, S. J., …Relton, C. L. (2021). A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer. Cancer Epidemiology, Biomarkers and Prevention, 30(3), 564-575. https://doi.org/10.1158/1055-9965.EPI-20-1176

Background: Evidence for aspirin’s chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of action is not well-understood. We combined a proteomic approach with Mendelian randomization (MR) to identify possible new... Read More about A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer.

Novel method for the measurement of erythrocyte acetylcholinesterase activity in the Yt blood group system using amperometry in conjunction with screen-printed carbon electrodes (2020)
Journal Article
Crew, A., Karamatic Crew, V., Bagelow, L., Walser, P., Thornton, N., & Hart, J. (2020). Novel method for the measurement of erythrocyte acetylcholinesterase activity in the Yt blood group system using amperometry in conjunction with screen-printed carbon electrodes. Vox Sanguinis, 115(S1), 271-271. https://doi.org/10.1111/vox.13031

Background: The five antigens of the Yt blood group system are located on the membrane GPI‐linked erythrocyte acetylcholinesterase (AChE‐E), which is implicated in a range of clinical issues, including sleep apnoea and neurotoxin poisoning. Conformat... Read More about Novel method for the measurement of erythrocyte acetylcholinesterase activity in the Yt blood group system using amperometry in conjunction with screen-printed carbon electrodes.

Laboratory evaluation of the Sigma Transwab® transport system for the recovery of Candida species using the Clinical and Laboratory Standards Institute (CLSI) document M40-A2 (2020)
Journal Article
Adukwu, E., & Elcocks, E. (2021). Laboratory evaluation of the Sigma Transwab® transport system for the recovery of Candida species using the Clinical and Laboratory Standards Institute (CLSI) document M40-A2. European Journal of Clinical Microbiology and Infectious Diseases, 40, 735-738. https://doi.org/10.1007/s10096-020-04062-9

Rising healthcare complications due to fungal infections increase the importance of efficient specimen collection and maintenance systems for correct identification and diagnosis. The CLSI M40-A2 protocol provides guidelines for laboratories assessin... Read More about Laboratory evaluation of the Sigma Transwab® transport system for the recovery of Candida species using the Clinical and Laboratory Standards Institute (CLSI) document M40-A2.

In vitro antifungal activity of Cinnamomum zeylanicum bark and leaf essential oils against Candida albicans and Candida auris (2020)
Journal Article
Tran, H. N. H., Graham, L., & Adukwu, E. C. (2020). In vitro antifungal activity of Cinnamomum zeylanicum bark and leaf essential oils against Candida albicans and Candida auris. Applied Microbiology and Biotechnology, 104, 8911–8924. https://doi.org/10.1007/s00253-020-10829-z

Candida infections are a significant source of patient morbidity and mortality. Candida albicans is the most common pathogen causing Candida infections. Candida auris is a newly described pathogen that is associated with multi-drug-resistant candidia... Read More about In vitro antifungal activity of Cinnamomum zeylanicum bark and leaf essential oils against Candida albicans and Candida auris.

An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy (2020)
Journal Article
Russell, G., Rehman, M., LeBaron, T. W., Veal, D., Adukwu, E., & Hancock, J. (2020). An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy. Reactive Oxygen Species, 10(28), 150–165

SARS-CoV-2 is an emerging β-coronavirus that causes COVID-19 disease that manifests primarily as a pulmonary infection that can rapidly progress into severe and acute respiratory distress in susceptible patients. Initial reports of severe pulmonary i... Read More about An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy.

ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia? (2020)
Journal Article
Vahabi, B., Jabr, R., Fry, C., McCloskey, K., Everaert, K., Agudelo, C. W., …Weiss, J. P. (2020). ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?. Neurourology and Urodynamics, 39(S3 Supplement: ICI‐RS 2019), S88-S95. https://doi.org/10.1002/nau.24274

Introduction: The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). Objectives: The objectives of the 2019 NTT were as follows: (a) to evaluate the role of urot... Read More about ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?.

Aluminium Induced DNA-damage and Oxidative Stress in Cultures of the Marine Sponge Hymeniacidon perlevis (2019)
Journal Article
Akpiri, R. U., Hodges, N. J., & Konya, R. S. (2020). Aluminium Induced DNA-damage and Oxidative Stress in Cultures of the Marine Sponge Hymeniacidon perlevis. Journal of Marine Science, 2(1), https://doi.org/10.30564/jms.v2i1.1070

Aluminium is the most abundant element in the earth crust, and has no known biological function. However, it is an established neurotoxicant in its trivalent oxidation state, with exposure resulting in neurodegenerative diseases like Parkinson’s dise... Read More about Aluminium Induced DNA-damage and Oxidative Stress in Cultures of the Marine Sponge Hymeniacidon perlevis.

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). (2019)
Journal Article
Gynn, L. E., Anderson, E., Robinson, G. M., Wexler, S. A., Upstill-Goddard, G., Cox, C., …Morgan, R. G. (2019). Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). Blood, 134(Supplement 1), 2492. https://doi.org/10.1182/blood-2019-122891

Mesenchymal stromal cells (MSC) are known to protect leukemic cells from drug-induced toxicity within the bone marrow (BM) niche, however, less is known about leukemic impact on supportive MSC. The nucleoside-analogue, cytarabine (Ara-C), is a front-... Read More about Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)..

Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films (2019)
Patent
Cox, T., Kiely, J., Ratcliffe, N., deLacy Costello, B., & Luxton, R. (2019). Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films

The invention relates to the field of sensors for detecting volatile compounds. The sensor of the present invention for detecting volatile compounds comprises: a film of metal oxide; a heater configured to provide heat energy to the film of metal oxi... Read More about Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films.

Evaluation of antifungal activities and antihaemolytic effects of cinnamon essential oils from leaf and bark on Candida albicans and Candida auris (2019)
Presentation / Conference
Tran, H., & Adukwu, E. (2019, June). Evaluation of antifungal activities and antihaemolytic effects of cinnamon essential oils from leaf and bark on Candida albicans and Candida auris. Poster presented at Microbiology Society ECM Forum Summer Conference, Dublin, Ireland

Candida infections can be considered as a significant source of patient morbidity and mortality. Candida albicans is the most common pathogen causing Candida infections. Candida auris is a newly described pathogen that is associated with multi-drug r... Read More about Evaluation of antifungal activities and antihaemolytic effects of cinnamon essential oils from leaf and bark on Candida albicans and Candida auris.

Evaluation of Two Sigma TranswabⓇ Systems for maintenance of viability of pathogenic Candida spp. using the clinical and laboratory standards institute M40-A2 standard (2019)
Presentation / Conference
Elcocks, E., & Adukwu, E. (2019, March). Evaluation of Two Sigma TranswabⓇ Systems for maintenance of viability of pathogenic Candida spp. using the clinical and laboratory standards institute M40-A2 standard. Poster presented at KNVM & NVNM Scientific Spring Meeting 2019, Papendal, Netherlands

In vitro antimicrobial activity of Cymbopogon flexuosus against Staphylococcus aureus and Acinetobacter baumannii (2018)
Presentation / Conference
Green, N., & Adukwu, E. (2018, June). In vitro antimicrobial activity of Cymbopogon flexuosus against Staphylococcus aureus and Acinetobacter baumannii. Poster presented at ECM Forum Summer Conference 2018, Birmingham, UK

Staphylococcus aureus (S. aureus) and Acinetobacter baumannii (A. baumannii) are both significant nosocomial pathogens that have become increasingly resistant to conventional antimicrobial therapies. There is a need for alternative therapies to com... Read More about In vitro antimicrobial activity of Cymbopogon flexuosus against Staphylococcus aureus and Acinetobacter baumannii.

The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients (2018)
Journal Article
Peyravian, N., Larki, P., Gharib, E., Nazemalhosseini-Mojarad, E., Anaraki, F., Young, C., …Zali, M. (2018). The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients. Biomedicines, 6(1), 27. https://doi.org/10.3390/biomedicines6010027

A key factor in determining the likely outcome for a patient with colorectal cancer is whether or not the tumour has metastasised to the lymph nodes-information which is also important in assessing any possibilities of lymph node resection so as to i... Read More about The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients.

GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients (2018)
Journal Article
Hadizadeh, M., Mohaddes Ardebili, S., Salehi, M., Young, C., Mokarian, F., McClellan, J., …Bonab, M. A. (2018). GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients. Biomedicines, 6(1), 23. https://doi.org/10.3390/biomedicines6010023

Lymphedema is a condition resulting from mutations in various genes essential for lymphatic development and function, which leads to obstruction of the lymphatic system. Secondary lymphedema is a progressive and incurable condition, most often manife... Read More about GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients.

Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS) (2017)
Journal Article
May, J., Robinson, G., Thorn, R., & Reynolds, D. (2017). Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS). Mutagenesis, 32(6), 622-623. https://doi.org/10.1093/mutage/gex033

Electrochemically activated solutions (ECAS) are of interest as potential disinfectants due to high biocidal activity against many microorganisms. They are widely used clinically in some countries (decontamination of surgical instruments and wounds),... Read More about Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS).