Jason Mansell's Outputs (22)

Hypoxia compromises the differentiation of human osteosarcoma cells to CAR-R, a hydroxylated derivative of lithocholic acid and potent agonist of the vitamin D receptor (2025)
Journal Article

The active metabolite of vitamin D3, calcitriol (1,25D), is widely recognised for its direct anti-proliferative and pro-differentiation effects. However, 1,25D is calcaemic, which restricts its clinical use for cancer treatment. Non-calcaemic agonist... Read More about Hypoxia compromises the differentiation of human osteosarcoma cells to CAR-R, a hydroxylated derivative of lithocholic acid and potent agonist of the vitamin D receptor.

Comparison of MXene and SWCNTs effectiveness for osteoblast differentiation: A preliminary study with MG-63 cells (2024)
Journal Article

The exceptional chemical and physical properties of nanomaterials have attracted growing interest in the field of bone tissue engineering. Single walled carbon nanotubes (SWCNTs) and MXenes are two types of unique nanomaterials that have shown promis... Read More about Comparison of MXene and SWCNTs effectiveness for osteoblast differentiation: A preliminary study with MG-63 cells.

Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation (2023)
Journal Article

Aim: This study aimed to investigate the potential of ternary nanocomposite (TNC) to support MG63 osteoblast maturation to EB1089-(3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1-phosphonate (FHBP) cotreatment. Materials & methods: Binary (P25/reduced gra... Read More about Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation.

An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation (2023)
Journal Article

Less-calcaemic vitamin D receptor (VDR) agonists have the potential to promote osteoblast maturation in a bone regenerative setting. The emergence of lithocholic acid (LCA) as a bona fide VDR agonist holds promise as an adjunct for arthroplasty follo... Read More about An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation.

Development of an antimicrobial lipid coating to prevent infections in uncemented joint replacements (2023)
Presentation / Conference Contribution

Preventing infections in joint replacements is a major ongoing challenge, with limited effective clinical technologies currently available for uncemented knee and hip prostheses. This research aims to develop a coating for titanium implants, consisti... Read More about Development of an antimicrobial lipid coating to prevent infections in uncemented joint replacements.

Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus (2022)
Journal Article

Antibacterial bone biomaterial coatings appeal to orthopaedics, dentistry and veterinary medicine. Achieving the successful, stable conjugation of suitable compounds to biomaterial surfaces is a major challenge. A pragmatic starting point is to make... Read More about Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus.

Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications (2020)
Journal Article

Background: Aseptic loosening of total joint replacements (TJRs) continues to be the main cause of implant failures. The socioeconomic impact of surgical revisions is hugely significant; in the United Kingdom alone, it is estimated that £137 m is spe... Read More about Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications.

Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Aseptic loo... Read More about Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications.

The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties (2018)
Journal Article

© 2018 The oncogene ERG encodes an ETS family transcription factor and is implicated in blood, vascular, and bone development and in prostate, blood, and bone cancer. The ERG gene is alternatively spliced; of particular interest is its cassette exon... Read More about The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties.

Development and biological evaluation of fluorophosphonate-modified hydroxyapatite for orthopaedic applications (2018)
Journal Article

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Abstract: There is an incentive to functionalise hydroxyapatite (HA) for orthopaedic implant use with bioactive agents to encourage superior integration of the implants into host... Read More about Development and biological evaluation of fluorophosphonate-modified hydroxyapatite for orthopaedic applications.

Alkaline phosphatase binds tenaciously to titanium; implications for biological surface evaluation following bone implant retrieval (2017)
Journal Article

© 2017 Elsevier B.V. Enhancing the performance and longevity of titanium (Ti) implants continues to be a significant developmental theme in contemporary biomaterials design. Our specific focus pertains to the surface functionalisation of Ti using the... Read More about Alkaline phosphatase binds tenaciously to titanium; implications for biological surface evaluation following bone implant retrieval.

Chitinase 3-like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25-dihydroxyvitamin D3 (2016)
Journal Article

© 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) Chitinase 3-like 1, otherwise known as YKL-40, is a secreted glycoprotein purported to have a role in extracellular matrix metabolism. The first mammalian cell ty... Read More about Chitinase 3-like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25-dihydroxyvitamin D3.

Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications (2015)
Journal Article

© 2015, Springer Science+Business Media New York. Abstract: Enhancing vitamin D-induced human osteoblast (hOB) maturation at bone biomaterial surfaces is likely to improve prosthesis integration with resultant reductions in the need for revision art... Read More about Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications.

Dual Action of lysophosphatidate- functionalised titanium: Interactions with human (MG63) osteoblasts and methicillin resistant staphylococcus aureus (2015)
Journal Article

© 2015 Skindersoe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are... Read More about Dual Action of lysophosphatidate- functionalised titanium: Interactions with human (MG63) osteoblasts and methicillin resistant staphylococcus aureus.

24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation (2014)
Journal Article

Vitamin D receptor (VDR) agonists supporting human osteoblast (hOB) differentiation in the absence of bone resorption are attractive agents in a bone regenerative setting. One potential candidate fulfilling these roles is 24,25-dihydroxy vitamin D3 (... Read More about 24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation.

Convergence of vitamin D and lysophosphatidic acid signaling in stimulating human osteoblast maturation (2014)
Journal Article

N/A

Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662 (2014)
Journal Article

Metformin (Met) is a biguanide drug widely used in the treatment and management of non insulin-dependent diabetes mellitus. In recent years it has emerged that Met, by stimulating adenosine monophosphate-activated protein kinase (AMPK), can promote t... Read More about Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662.

Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation (2012)
Journal Article

Covalent modifications of titanium with small molecules
known to promote human osteoblast maturation are
especially attractive in developing superior biomaterials.
An important step in securing competent bone formation
at implant sites is promoti... Read More about Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation.

The emerging role of lysophosphatidic acid (LPA) in skeletal biology (2012)
Journal Article

Lysophosphatidic acid (LPA) is the simplest signalling lipid eliciting pleiotropic actions upon most mammalian cell types. Although LPA has an established role in many biological processes, particularly wound healing and cancer, the participation of... Read More about The emerging role of lysophosphatidic acid (LPA) in skeletal biology.

Lysophosphatidic acid and calcitriol co-operate to promote human osteoblastogenesis: Requirement of albumin-bound LPA (2011)
Journal Article

Lysophosphatidic acid (LPA), a pleiotropic signalling lipid is assuming growing significance in osteoblast biology. Although committed osteoblasts from several mammalian species are receptive to LPA far less is known about the potential for LPA to in... Read More about Lysophosphatidic acid and calcitriol co-operate to promote human osteoblastogenesis: Requirement of albumin-bound LPA.