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An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS (2013)
Journal Article
Ratcliffe, N., De Lacy Costello, B., Al-Kateb, H., de Lacy Costello, B., & Ratcliffe, N. M. (2013). An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS. Journal of Breath Research, 7(3), https://doi.org/10.1088/1752-7155/7/3/036004

Analysis of volatile organic compounds (VOCs) from saliva, to aid disease diagnoses, has received little attention. This work aims to address the paucity of information on saliva volatiles and includes a database of newly identified compounds whilst... Read More about An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS.

Multidimensional model to assess the readiness of Saudi Arabia to implement evidence based child maltreatment prevention programs at a large scale (2013)
Journal Article
Almuneef, M. A., Qayad, M., Noor, I. K., Al-Eissa, M. A., AlBuhairan, F. S., Inam, S., & Mikton, C. (2014). Multidimensional model to assess the readiness of Saudi Arabia to implement evidence based child maltreatment prevention programs at a large scale. Child Abuse and Neglect, 38(3), 527-532. https://doi.org/10.1016/j.chiabu.2013.08.001

There has been increased awareness of child maltreatment in Saudi Arabia recently. This study assessed the readiness for implementing large-scale evidence-based child maltreatment prevention programs in Saudi Arabia. Key informants, who were key deci... Read More about Multidimensional model to assess the readiness of Saudi Arabia to implement evidence based child maltreatment prevention programs at a large scale.

The effect of aqueous extract of Euphorbia drupifera on the physiology of wistar rat (2013)
Journal Article
Akpiri, R., Roseline, K. S., & Abigail, J. (2013). The effect of aqueous extract of Euphorbia drupifera on the physiology of wistar rat. International Journal of Pharmacological Research, 3(2), 23-26. https://doi.org/10.7439/ijpr.v3i2.48

The plant Euphorbia came from Mount Atlas region of present-day Morocco and was probably the resin Spurge. This local herb is used by traditional herbalists for treatment of hypertension, diabetes and several other ailments. The aim of this study is... Read More about The effect of aqueous extract of Euphorbia drupifera on the physiology of wistar rat.

Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling (2013)
Journal Article
Crompton, L. A., Byrne, M. L., Taylor, H., Kerrigan, T. L., Bru-Mercier, G., Badger, J. L., …Caldwell, M. A. (2013). Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling. Stem Cell Research, 11(3), 1206-1221. https://doi.org/10.1016/j.scr.2013.08.002

Basal forebrain cholinergic neurons (bfCNs) which provide innervation to the hippocampus and cortex, are required for memory and learning, and are primarily affected in Alzheimer's Disease (AD), resulting in related cognitive decline. Therefore gener... Read More about Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.

The evolution of selective analyses of HDL and LDL cholesterol in clinical and point of care testing (2013)
Journal Article
Killard, A. J., Ahmadraji, T., & Killard, A. (2013). The evolution of selective analyses of HDL and LDL cholesterol in clinical and point of care testing. Analytical Methods, 5(15), 3612-3625. https://doi.org/10.1039/c3ay40715b

Cardiovascular disease is a leading cause of death worldwide and is caused by the build up of atherosclerotic plaques in the vasculature. It is now well established that the formation of these plaques is closely related to levels of both high density... Read More about The evolution of selective analyses of HDL and LDL cholesterol in clinical and point of care testing.

Effect of breed on fatty acid composition and lipogenic enzyme abundance in the subcutaneous adipose tissue of pigs (2013)
Journal Article
Marriott, D. T., Chevillon, P., Spencer-Phillips, P. T., & Doran, O. (2013). Effect of breed on fatty acid composition and lipogenic enzyme abundance in the subcutaneous adipose tissue of pigs. Journal of Food Science, 78(8), C1130-C1135. https://doi.org/10.1111/1750-3841.12191

This study investigated the role of lipogenic enzyme expression in breed-specific fat deposition in pigs. Objectives: (i) determine effect of breed on the relative abundance of the key lipogenic enzymes stearoyl-CoA desaturase (SCD), delta-6 desatura... Read More about Effect of breed on fatty acid composition and lipogenic enzyme abundance in the subcutaneous adipose tissue of pigs.

Ecology of reproduction in Sanje mangabeys (Cercocebus sanjei): Dietary strategies and energetic condition during a high fruit period (2013)
Journal Article
Mccabe, G. M., Fernández, D., & Ehardt, C. L. (2013). Ecology of reproduction in Sanje mangabeys (Cercocebus sanjei): Dietary strategies and energetic condition during a high fruit period. American Journal of Primatology, 75(12), 1196-1208. https://doi.org/10.1002/ajp.22182

The ability to increase energy storage when food is abundant for later use during late gestation and early lactation is often considered the primary benefit of the capital breeding strategy (clustering conceptions during high food periods, HFP) that... Read More about Ecology of reproduction in Sanje mangabeys (Cercocebus sanjei): Dietary strategies and energetic condition during a high fruit period.

Differential effects of reduced protein diets on fatty acid composition and gene expression in muscle and subcutaneous adipose tissue of Alentejana purebred and Large White ×â Landrace ×â Pietrain crossbred pigs (2013)
Journal Article
Prates, J. A., Pires, V. M., Bessa, R. J., Madeira, M. S., Pires, V., Alfaia, C. M., …Prates, J. (2013). Differential effects of reduced protein diets on fatty acid composition and gene expression in muscle and subcutaneous adipose tissue of Alentejana purebred and Large White ×â Landrace ×â Pietrain crossbred pigs. British Journal of Nutrition, 110(02), 216-229. https://doi.org/10.1017/S0007114512004916

The present study assessed the effect of pig genotype (fatty v. lean) and dietary protein and lysine (Lys) levels (normal v. reduced) on intramuscular fat (IMF) content, subcutaneous adipose tissue (SAT) deposition, fatty acid composition and mRNA le... Read More about Differential effects of reduced protein diets on fatty acid composition and gene expression in muscle and subcutaneous adipose tissue of Alentejana purebred and Large White ×â Landrace ×â Pietrain crossbred pigs.

Underpotential deposition of lead at silver electrodes manufactured from compact discs and its determination in environmental water samples (2013)
Journal Article
Honeychurch, K. C. (2013). Underpotential deposition of lead at silver electrodes manufactured from compact discs and its determination in environmental water samples. Advances in Analytical Chemistry, 3(3A), 28-33. https://doi.org/10.5923/s.aac.201307.05

The present paper describes the facile manufacture of silver electrodes from compact discs for the anodic stripping voltammetric determination of lead. The voltammetric behaviour of Pb in 0.1 M HCl was examined by cyclic voltammetry. Using a starting... Read More about Underpotential deposition of lead at silver electrodes manufactured from compact discs and its determination in environmental water samples.

Trpm8 agonists modulate contraction of the pig urinary bladder (2013)
Journal Article
Parsons, B. A., Drake, M. J., Vahabi, B., Parsons, B. A., Doran, O., Rhodes, A., …Drake, M. (2013). Trpm8 agonists modulate contraction of the pig urinary bladder. Canadian Journal of Physiology and Pharmacology, 91(7), 503-509. https://doi.org/10.1139/cjpp-2012-0406

The transient receptor potential melastin-8 (TRPM8) channel is activated by the "cooling" compounds menthol and icilin. Pathophysiologically, it is implicated in the overactive bladder and bladder cooling reflex, but the activity of TRPM8 in normal b... Read More about Trpm8 agonists modulate contraction of the pig urinary bladder.

AmBeR: The ammonia breath monitoring device (2013)
Presentation / Conference
Killard, A. (2013, July). AmBeR: The ammonia breath monitoring device. Paper presented at 56th Gas Analysis and Sensing Group Colloquium/NPL Measurement Network, Teddington, London

A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace (2013)
Journal Article
Ratcliffe, N., Probert, C. S., Ewen, R., Khalid, T., White, P., De Lacy Costello, B., …Ratcliffe, N. M. (2013). A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace. PLoS ONE, 8(7), https://doi.org/10.1371/journal.pone.0069602

There is a need to reduce the number of cystoscopies on patients with haematuria. Presently there are no reliable biomarkers to screen for bladder cancer. In this paper, we evaluate a new simple in-house fabricated, GC-sensor device in the diagnosis... Read More about A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace.

Observation, characterization and modeling of memristor current spikes (2013)
Journal Article
Gale, E., de Lacy Costello, B., & Adamatzky, A. (2013). Observation, characterization and modeling of memristor current spikes. https://doi.org/10.12785/amis/070418

Memristors have been compared to neurons (usually specifically the synapses) since 1976 but no experimental evidence has been offered for support for this position. Here we highlight that memristors naturally form fast-response, highly reproducible a... Read More about Observation, characterization and modeling of memristor current spikes.

Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells (2013)
Journal Article
Ladomery, M. R., Morse, H. R., Bowler, E., Mintoff, C. P., Chedea, V. S., Hagen, R. M., & Ladomery, M. (2013). Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells. International Journal of Oncology, 43(1), 194-200. https://doi.org/10.3892/ijo.2013.1920

Growing evidence suggests that the flavonoid epigallocatechin-3-gallate (EGCG), notably abundant in green tea, has health-promoting properties. We examined the effect of EGCG on cell survival and apoptosis in the prostate cancer cell line PC3. Cell s... Read More about Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells.

Award for revolutionary cholesterol testing device (2013)
Journal Article
Killard, A. (2013). Award for revolutionary cholesterol testing device

A team of European scientists led by UWE Bristol has won a prestigious international award for their research.

AmBeR: the breath ammonia monitoring device (2013)
Presentation / Conference
Killard, A. (2013, June). AmBeR: the breath ammonia monitoring device. Paper presented at Breath 2013, Wallerfangen, Saarbrucken, Germany

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk (2013)
Journal Article
Collard, T. J., Lane, J. D., Williams, A. C., Petherick, K. J., Petherick, K. J., Williams, A. C., …Greenhough, A. (2013). Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk. EMBO Journal, 32(13), 1903-1916. https://doi.org/10.1038/emboj.2013.123

The Wnt/β-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β-catenin signalling pathway as a negative regulator of both basal and stress-induc... Read More about Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk.