Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells

Hagen, Rachel M.; Chedea, Veronica S.; Mintoff, Christopher P.; Bowler, Elizabeth; Morse, H. Ruth; Ladomery, Michael R.; Ladomery, Michael

Abstract

Growing evidence suggests that the flavonoid epigallocatechin-3-gallate (EGCG), notably abundant in green tea, has health-promoting properties. We examined the effect of EGCG on cell survival and apoptosis in the prostate cancer cell line PC3. Cell survival was reduced and apoptosis increased significantly with a low dose of 1 μM EGCG. The ability of the anticancer drug cisplatin to promote apoptosis was enhanced by EGCG. Furthermore, EGCG, both alone and in combination with cisplatin, promoted the expression of the pro-apoptotic splice isoform of caspase 9.

Citation

Ladomery, M. R., Morse, H. R., Bowler, E., Mintoff, C. P., Chedea, V. S., Hagen, R. M., & Ladomery, M. (2013). Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells. International Journal of Oncology, 43(1), 194-200. https://doi.org/10.3892/ijo.2013.1920

• Journal Article Type: Article
• Publication Date: Jul 1, 2013
• Journal: International Journal of Oncology
• Print ISSN: 1019-6439
• Electronic ISSN: 1791-2423
• Publisher: Spandidos Publications
• Peer Reviewed: Peer Reviewed
• Volume: 43
• Issue: 1
• Pages: 194-200
• DOI: https://doi.org/10.3892/ijo.2013.1920
• Keywords: Epigallocatechin-3-gallate, apoptosis, expression, caspase 9a splice variant, PC3 prostate cancer cells
• Public URL: https://uwe-repository.worktribe.com/output/930368
• Publisher URL: http://dx.doi.org/10.3892/ijo.2013.1920