All Outputs (5)

Carotid body dysregulation contributes to Long COVID symptoms (2024)
Journal Article
El-Medany, A., Adams, Z. H., Blythe, H. C., Hope, K. A., Kendrick, A. H., Abdala Sheikh, A. P., …Hart, E. C. (2024). Carotid body dysregulation contributes to Long COVID symptoms. communications medicine, 4(1), Article 20. https://doi.org/10.1038/s43856-024-00447-5

Patients with long COVID suffer from breathlessness during exercise, leading to exercise intolerance. We know that SARSCoV-2, the virus that causes COVID-19, can infect carotid bodies which is a small sensory organ that sends signals to the brain fo... Read More about Carotid body dysregulation contributes to Long COVID symptoms.

A systematic review on adherence to continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in individuals with mild cognitive impairment and Alzheimer's disease dementia (2023)
Journal Article
Oliver, C., Li, H., Biswas, B., Woodstoke, D., Blackman, J., Butters, A., …Coulthard, E. (2024). A systematic review on adherence to continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in individuals with mild cognitive impairment and Alzheimer's disease dementia. Sleep Medicine Reviews, 73, Article 101869. https://doi.org/10.1016/j.smrv.2023.101869

Obstructive sleep apnoea (OSA) is highly prevalent in mild cognitive impairment (MCI) and Alzheimer's disease (AD). The gold standard treatment for OSA is continuous positive airway pressure (CPAP). Long-term, well-powered efficacy trials are require... Read More about A systematic review on adherence to continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in individuals with mild cognitive impairment and Alzheimer's disease dementia.

Aging in females is associated with changes in respiratory modulation of sympathetic nerve activity and blood pressure (2023)
Journal Article
Adams, Z. H., Blythe, H. C., Charkoudian, N., Curry, T. B., Joyner, M. J., Kendrick, A. H., …Hart, E. C. (2023). Aging in females is associated with changes in respiratory modulation of sympathetic nerve activity and blood pressure. AJP - Heart and Circulatory Physiology, 325(5), H1108-H1117. https://doi.org/10.1152/ajpheart.00226.2023

Sympathetic nerve activity (SNA) is tightly coupled with the respiratory cycle. In healthy human males, respiratory modulation of SNA does not change with age. However, it is unclear how this modulation is affected by age in females. We investigated... Read More about Aging in females is associated with changes in respiratory modulation of sympathetic nerve activity and blood pressure.

Ventilatory efficiency is reduced in people with hypertension during exercise (2023)
Journal Article
Hope, K., Chant, B., Hinton, T., Kendrick, A. H., Nightingale, A. K., Paton, J. F., & Hart, E. C. (2023). Ventilatory efficiency is reduced in people with hypertension during exercise. Journal of the American Heart Association, 12(13), Article e024335. https://doi.org/10.1161/JAHA.121.024335

BACKGROUND: An elevated ventilatory efficiency slope during exercise (minute ventilation/volume of expired CO2; VE /VCO2 slope) is a strong prognostic indicator in heart failure. It is elevated in people with heart failure with preserved ejection, ma... Read More about Ventilatory efficiency is reduced in people with hypertension during exercise.

COVID-19-related changes in outpatient CPAP setup pathways for OSA are linked with decreased 30-day CPAP usage (2022)
Journal Article
Turnbull, C. D., Allen, M., Appleby, J., Brown, R., Bryan, N., Cooper, A., …Nickol, A. (2022). COVID-19-related changes in outpatient CPAP setup pathways for OSA are linked with decreased 30-day CPAP usage. Thorax, 77(8), 839-841. https://doi.org/10.1136/thoraxjnl-2021-218635

The COVID-19 pandemic changed continuous positive airway pressure (CPAP) setup pathways. We evaluated patients commenced on CPAP in 2019 (prepandemic) and 2020 (post-first UK wave). Face-to-face (F2F) setup numbers, with CPAP turned on, decreased fro... Read More about COVID-19-related changes in outpatient CPAP setup pathways for OSA are linked with decreased 30-day CPAP usage.