Aging in females is associated with changes in respiratory modulation of sympathetic nerve activity and blood pressure

Adams, Zoe H.; Blythe, Hazel C.; Charkoudian, Nisha; Curry, Timothy B.; Joyner, Michael J.; Kendrick, Adrian H.; Nightingale, Angus K.; Sheikh, P. Abdala; Hart, Emma C.

Abstract

Sympathetic nerve activity (SNA) is tightly coupled with the respiratory cycle. In healthy human males, respiratory modulation of SNA does not change with age. However, it is unclear how this modulation is affected by age in females. We investigated whether respiratory sympathetic modulation is altered in healthy postmenopausal (PMF) versus premenopausal female (YF), and younger male (YM) adults, and determined its relationship to resting blood pressure. Muscle SNA (MSNA; microneurography), respiration (transducer belt), ECG, and continuous blood pressure were measured in 12 YF, 13 PMF, and 12 YM healthy volunteers. Respiratory modulation of MSNA was quantified during two phases of the respiratory cycle: mid-late expiration and inspiration/postinspiration. All groups showed respiratory modulation of MSNA (P < 0.0005). There was an interaction between the respiratory phase and group for MSNA [bursts/100 heartbeats (HB) (P ¼ 0.004) and bursts/min (P ¼ 0.029)], with smaller reductions in MSNA during inspiration observed in PMF versus the other groups. Respiratory modulation of blood pressure was also reduced in PMF versus YF (6 [2] vs. 12 [9] mmHg, P ¼ 0.008) and YM (13 [13] mmHg, P ¼ 0.001, median [interquartile range]). The magnitude of respiratory sympathetic modulation was related to resting blood pressure in PMF only, such that individuals with less modulation had greater resting blood pressure. The data indicate that aging in postmenopausal females is associated with less inspiratory inhibition of MSNA. This correlated with a higher resting blood pressure in PMF only. Thus, the reduced modulation of MSNA could contribute to the age-related rise in blood pressure that occurs in females. NEW & NOTEWORTHY The current study demonstrates that respiratory modulation of sympathetic nerve activity (SNA) is reduced in healthy postmenopausal (PMF) versus premenopausal females (YF). Furthermore, respiratory sympathetic modulation was negatively related to resting blood pressure in postmenopausal females, such that blood pressure was greater in individual with less modulation. Reduced respiratory sympathetic modulation may have implications for the autonomic control of blood pressure in aging postmenopausal females, by contributing to age-related sympathetic activation and reducing acute, respiratory-linked blood pressure variation.

Citation

Adams, Z. H., Blythe, H. C., Charkoudian, N., Curry, T. B., Joyner, M. J., Kendrick, A. H., …Hart, E. C. (2023). Aging in females is associated with changes in respiratory modulation of sympathetic nerve activity and blood pressure. AJP - Heart and Circulatory Physiology, 325(5), H1108-H1117. https://doi.org/10.1152/ajpheart.00226.2023

• Journal Article Type: Article
• Acceptance Date: Aug 31, 2023
• Online Publication Date: Oct 9, 2023
• Publication Date: Nov 30, 2023
• Deposit Date: Mar 12, 2024
• Publicly Available Date: Mar 12, 2024
• Journal: American Journal of Physiology - Heart and Circulatory Physiology
• Print ISSN: 0363-6135
• Electronic ISSN: 1522-1539
• Publisher: American Physiological Society
• Peer Reviewed: Peer Reviewed
• Volume: 325
• Issue: 5
• Pages: H1108-H1117
• DOI: https://doi.org/10.1152/ajpheart.00226.2023
• Public URL: https://uwe-repository.worktribe.com/output/11793913