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All Outputs (12)

Exploring the current position of ESD in UK higher education institutions (2017)
Journal Article
Fiselier, E., Longhurst, J., & Gough, G. (2018). Exploring the current position of ESD in UK higher education institutions. International Journal of Sustainability in Higher Education, 19(2), 393-412. https://doi.org/10.1108/IJSHE-06-2017-0084

© 2018, Emerald Publishing Limited. Purpose: The purpose of this paper is to consider the position of education for sustainable development in the UK Higher Education (HE) sector with respect to the Quality Assurance Agency (QAA) and Higher Education... Read More about Exploring the current position of ESD in UK higher education institutions.

Preventing or inventing? Understanding the effects of non-prescriptive design briefs (2017)
Journal Article
Oliveira, S., & Marco, E. (2017). Preventing or inventing? Understanding the effects of non-prescriptive design briefs. International Journal of Technology and Design Education, 27(4), 549-561. https://doi.org/10.1007/s10798-016-9369-9

© 2016, The Author(s). This paper discusses observations of an architecture and environmental engineering undergraduate design studio project assigned to 4th year students at a UK university. In the UK, most architecture courses are characterised by... Read More about Preventing or inventing? Understanding the effects of non-prescriptive design briefs.

Conductive composites for oligonucleotide detection (2017)
Journal Article
Ferrier, D. C., Shaver, M. P., & Hands, P. J. (2018). Conductive composites for oligonucleotide detection. Sensing and Bio-Sensing Research, 17, 1-6. https://doi.org/10.1016/j.sbsr.2017.11.007

© 2017 The Authors A new method for oligonucleotide detection is presented based on oligonucleotide cross-linked polymer composites. Conductive carbon nanoparticles are incorporated into a DNA-functionalised polymer, containing partially complementar... Read More about Conductive composites for oligonucleotide detection.

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme (2017)
Journal Article
Bharate, S. B., Chaudhuri, B., Vishwakarma, R. A., Jain, S. K., Sharma, R., Gatchie, L., & Williams, I. S. (2017). Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme. Bioorganic and Medicinal Chemistry Letters, 27(24), 5400-5403. https://doi.org/10.1016/j.bmcl.2017.11.013

© 2017 Elsevier Ltd The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. With a... Read More about Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.

(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent (2017)
Journal Article
Horley, N. J., Beresford, K. J., Kaduskar, S., Joshi, P., McCann, G. J., Ruparelia, K. C., …Chaudhuri, B. (2017). (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent. Bioorganic and Medicinal Chemistry Letters, 27(24), 5409-5414. https://doi.org/10.1016/j.bmcl.2017.11.009

The overexpression of CYP1 family of enzymes is reported to be associated with development of human carcinomas. It has been well reported that CYP1A1 specific inhibitors prevents carcinogenesis. Herein, thirteen pyridine-4-yl series of chalcones were... Read More about (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent.

Exploring urban metabolism—Towards an interdisciplinary perspective (2017)
Journal Article
Urge-Vorsatz, D., Rosales Carreón, J., Mokhtarian, P. L., Dijst, M., Worrell, E., Böcker, L., …Zeyringer, M. (2018). Exploring urban metabolism—Towards an interdisciplinary perspective. Resources, Conservation and Recycling, 132, 190-203. https://doi.org/10.1016/j.resconrec.2017.09.014

© 2017 The Author(s) The discussion on urban metabolism has been long dominated by natural scientists focussing on natural forces shaping the energy and material flows in urban systems. However, in the anthropocene human forces such as industrializat... Read More about Exploring urban metabolism—Towards an interdisciplinary perspective.

Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme (2017)
Journal Article
Bharate, S. B., Nuthakki, V. K., Williams, I. S., Chib, S., Gatchie, L., Joshi, P., …Chaudhuri, B. (2017). Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme. Journal of Agricultural and Food Chemistry, 65(34), 7440-7446. https://doi.org/10.1021/acs.jafc.7b02690

© 2017 American Chemical Society. Naturally occurring polyphenolic compounds are of medicinal importance because of their unique antioxidant, anticancer, and chemopreventive properties. Baicalein, a naturally occurring polyhydroxy flavonoid possessin... Read More about Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme.

The dynamics of urban metabolism in the face of digitalization and changing lifestyles: Understanding and influencing our cities (2017)
Journal Article
Lyons, G., Mokhtarian, P., Dijst, M., & Böcker, L. (2018). The dynamics of urban metabolism in the face of digitalization and changing lifestyles: Understanding and influencing our cities. Resources, Conservation and Recycling, 132, 246-257. https://doi.org/10.1016/j.resconrec.2017.07.032

© 2017 Elsevier B.V. The world's population continues to grow. With a trend of urbanisation apparent, increasing attention is now being given to understanding and shaping our cities to support an evolving society. Urban metabolism concerns the flows... Read More about The dynamics of urban metabolism in the face of digitalization and changing lifestyles: Understanding and influencing our cities.

Supervised Autonomy for Online Learning in Human-Robot Interaction (2017)
Journal Article
Senft, E., Baxter, P., Kennedy, J., Lemaignan, S., & Belpaeme, T. (2017). Supervised Autonomy for Online Learning in Human-Robot Interaction. Pattern Recognition Letters, 99, 77-86. https://doi.org/10.1016/j.patrec.2017.03.015

© 2017 When a robot is learning it needs to explore its environment and how its environment responds on its actions. When the environment is large and there are a large number of possible actions the robot can take, this exploration phase can take pr... Read More about Supervised Autonomy for Online Learning in Human-Robot Interaction.

Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines (2017)
Journal Article
Horley, N. J., Beresford, K. J., Chawla, T., McCann, G. J., Ruparelia, K. C., Gatchie, L., …Chaudhuri, B. (2017). Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. European Journal of Medicinal Chemistry, 129, 159-174. https://doi.org/10.1016/j.ejmech.2017.02.016

© 2017 Elsevier Masson SAS The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of syn... Read More about Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.

Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance (2017)
Journal Article
Satti, N. K., Williams, I. S., Joshi, P., Gatchie, L., Sharma, M., Vishwakarma, R. A., …Bharate, S. B. (2017). Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance. Bioorganic and Medicinal Chemistry Letters, 27(16), 3683-3687. https://doi.org/10.1016/j.bmcl.2017.07.010

© 2017 Elsevier Ltd Inhibitors of CYP1 enzymes may play vital roles in the prevention of cancer and overcoming chemo-resistance to anticancer drugs. In this letter, we report synthesis of twenty-three pyrrole based heterocyclic chalcones which were s... Read More about Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance.