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An operative method to obtain sharp nonlinear stability for systems with spatially dependent coefficients (2012)
Journal Article
Hill, A. A., & Malashetty, M. S. (2012). An operative method to obtain sharp nonlinear stability for systems with spatially dependent coefficients. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 468(2138), 323-336. https://doi.org/10.1098/rspa.2011.0137

This paper explores an operative technique for deriving nonlinear stability by studying double-diffusive porous convection with a concentration-based internal heat source. Previous stability analyses on this problem have yielded regions of potential... Read More about An operative method to obtain sharp nonlinear stability for systems with spatially dependent coefficients.

Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase (2012)
Journal Article
Coles, S. J., Hancock, J. T., & Conway, M. E. (2012). Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase. Acta Biochimica et Biophysica Sinica, 44(2), 172-176. https://doi.org/10.1093/abbs/gmr103

The human branched-chain aminotransferase (hBCAT) isoenzymes are CXXC motif redox sensitive homodimers central to glutamate metabolism in the central nervous system. These proteins respond differently to oxidation by H 2O 2, NO, and S-glutathionylati... Read More about Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase.

Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways (2012)
Journal Article
Dallosso, A., Oster, B., Greenhough, A., Thorsen, K., Curry, T., Owen, C., …Malik, K. (2012). Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways. Oncogene, 31, 4409-4419

Loss of tumor suppressor gene function can occur as a result of epigenetic silencing of large chromosomal regions, referred to as long-range epigenetic silencing (LRES) and genome-wide analyses have revealed that LRES is present in many cancer types.... Read More about Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.

High throughput high content reverse genetics visual screens of ciliogenesis and cilia maintenance (2012)
Journal Article
Szymanska, K., Wheway, G., Natarajan, S., Higgins, J., Adams, M., Tomlinson, D. C., & Johnson, C. A. (2012). High throughput high content reverse genetics visual screens of ciliogenesis and cilia maintenance. Cilia, 1(S1), P49. https://doi.org/10.1186/2046-2530-1-S1-P49

Cilia are small, hair-like structures occurring on the apical surface of most of vertebrate cells. Defects in cilia cause a range of developmental phenotypes grouped into conditions called ciliopathies. Our aim is to dissect the structure and functio... Read More about High throughput high content reverse genetics visual screens of ciliogenesis and cilia maintenance.

Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy (2012)
Journal Article
Wang, Z., Kiely, J., Vargas, A. M., & Luxton, R. W. (2012). Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy. Procedia Chemistry, 6, 89-99. https://doi.org/10.1016/j.proche.2012.10.134

This paper decides an impedance spectroscopy measurement system for real-time monitoring of cellular toxicity. The system is used to compare the impedance response of ECV304 cells to two toxicants, dimethyl sulphoxide (DMSO) and sodium butyrate. The... Read More about Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy.

Engaging teenagers with genetics and genomics through a school-based competition: Pilot evaluation (2012)
Journal Article
Weitkamp, E., & Arnold, D. L. (2012). Engaging teenagers with genetics and genomics through a school-based competition: Pilot evaluation. International Journal of Science and Society, 4(1), 63-68

As part of a university outreach programme, the authors ran an interschool competition encouraging young people (year 10, age 14–15) to explore their ideas about the likely social impacts of whole genome screening. Schools participating in the comp... Read More about Engaging teenagers with genetics and genomics through a school-based competition: Pilot evaluation.

MKS1 interacts with components of the ubiquitin-proteasome pathway to regulate ciliogenesis and multiple signalling pathways (2012)
Journal Article
Wheway, G., Abdelhamed, Z., Natarajan, S., & Johnson, C. A. (2012). MKS1 interacts with components of the ubiquitin-proteasome pathway to regulate ciliogenesis and multiple signalling pathways. Cilia, 1(S1), P108. https://doi.org/10.1186/2046-2530-1-S1-P108

MKS1, a ciliary protein containing a B9 domain of unknown function, plays an important role in ciliogenesis. Mutation of the MKS1 gene causes the neonatal lethal multi-organ developmental condition Meckel-Gruber syndrome, characterized by severe cili... Read More about MKS1 interacts with components of the ubiquitin-proteasome pathway to regulate ciliogenesis and multiple signalling pathways.

Prevalence and risk of violence against children with disabilities: A systematic review and meta-analysis of observational studies (2012)
Journal Article
Bellis, M. A., Jones, L., Wood, S., Hughes, K., McCoy, E., Eckley, L., …Officer, A. (2012). Prevalence and risk of violence against children with disabilities: A systematic review and meta-analysis of observational studies. Lancet, 380(9845), 899-907. https://doi.org/10.1016/S0140-6736%2812%2960692-8

Summary Background Globally, at least 93 million children have moderate or severe disability. Children with disabilities are thought to have a substantially greater risk of being victims of violence than are their non-disabled peers. Establishment of... Read More about Prevalence and risk of violence against children with disabilities: A systematic review and meta-analysis of observational studies.

Prevalence and risk of violence against adults with disabilities: A systematic review and meta-analysis of observational studies (2012)
Journal Article
Bellis, M. A., Hughes, K., Jones, L., Wood, S., Bates, G., Eckley, L., …Officer, A. (2012). Prevalence and risk of violence against adults with disabilities: A systematic review and meta-analysis of observational studies. Lancet, 379(9826), 1621-1629. https://doi.org/10.1016/S0140-6736%2811%2961851-5

Background About 15% of adults worldwide have a disability. These individuals are frequently reported to be at increased risk of violence, yet quantitative syntheses of studies of this issue are scarce. We aimed to quantify violence against adults wi... Read More about Prevalence and risk of violence against adults with disabilities: A systematic review and meta-analysis of observational studies.

Novel electrode reactions of diazepam, flunitrazepam and lorazepam and their exploitation in a new redox mode LC-DED assay for serum (2012)
Journal Article
Honeychurch, K. C., Chong, A. T., Elamin, K., & Hart, J. P. (2012). Novel electrode reactions of diazepam, flunitrazepam and lorazepam and their exploitation in a new redox mode LC-DED assay for serum. Analytical Methods, 4(1), 132-140. https://doi.org/10.1039/c1ay05419h

Previously unreported voltammetric redox behaviour was identified for flunitrazepam, lorazepam and diazepam at a glassy carbon electrode. This was successfully exploited for their determination in serum by high performance liquid chromatography dual... Read More about Novel electrode reactions of diazepam, flunitrazepam and lorazepam and their exploitation in a new redox mode LC-DED assay for serum.

Maintaining functional major histocompatibility complex diversity under inbreeding: The case of a selfing vertebrate (2012)
Journal Article
Allainguillaume, J., Ellison, A., Allainguillaume, J., Girdwood, S., Pachebat, J., Peat, K. M., …Consuegra, S. (2012). Maintaining functional major histocompatibility complex diversity under inbreeding: The case of a selfing vertebrate. Proceedings of the Royal Society B: Biological Sciences, 279(1749), 5004-5013. https://doi.org/10.1098/rspb.2012.1929

Major histocompatibility complex (MHC) genes encode proteins that present pathogen-derived antigens to T-cells, initiating the adaptive immune response in vertebrates. Although populations with low MHC diversity tend to be more susceptible to pathoge... Read More about Maintaining functional major histocompatibility complex diversity under inbreeding: The case of a selfing vertebrate.

Stability of double-diffusive convection induced by selective absorption of radiation in a fluid layer (2012)
Journal Article
Wicks, T. J., & Hill, A. A. (2012). Stability of double-diffusive convection induced by selective absorption of radiation in a fluid layer. Continuum Mechanics and Thermodynamics, 24(3), 229-237. https://doi.org/10.1007/s00161-012-0234-0

Linear and nonlinear stability analyses were performed on a fluid layer with a concentration-based internal heat source. Clear bimodal behaviour in the neutral curve (with stationary and oscillatory modes) is observed in the region of the onset of os... Read More about Stability of double-diffusive convection induced by selective absorption of radiation in a fluid layer.