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All Outputs (77)

Mapping the hinterland: Data issues in open science (2014)
Journal Article
Grand, A., Wilkinson, C., Bultitude, K., & Winfield, A. F. (2014). Mapping the hinterland: Data issues in open science. Public Understanding of Science, 25(1), 88-103. https://doi.org/10.1177/0963662514530374

© The Author(s) 2014. Open science is a practice in which the scientific process is shared completely and in real time. It offers the potential to support information flow, collaboration and dialogue among professional and non-professional participan... Read More about Mapping the hinterland: Data issues in open science.

Microbial acetone oxidation in coastal seawater (2014)
Journal Article
Nightingale, P. D., Tarran, G. A., Dixon, J. L., Beale, R., & Sargeant, S. (2014). Microbial acetone oxidation in coastal seawater. Frontiers in Microbiology, 5(MAY), https://doi.org/10.3389/fmicb.2014.00243

Acetone is an important oxygenated volatile organic compound (OVOC) in the troposphere where it influences the oxidizing capacity of the atmosphere. However, the air-sea flux is not well quantified, in part due to a lack of knowledge regarding which... Read More about Microbial acetone oxidation in coastal seawater.

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl (2014)
Journal Article
Chapman, K., Thomas, A. D., Wills, J., Pfuhler, S., Doak, S. H., & Jenkins, G. J. (2014). Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl. Mutagenesis, 29(3), 165-175. https://doi.org/10.1093/mutage/geu011

Recent restrictions on the testing of cosmetic ingredients in animals have resulted in the need to test the genotoxic potential of chemicals exclusively in vitro prior to licensing. However, as current in vitro tests produce some misleading positive... Read More about Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl.

A review of the volatiles from the healthy human body (2014)
Journal Article
Ratcliffe, N. M., Al-Kateb, H., De Lacy Costello, B., de Lacy Costello, B., Amann, A., Al-Kateb, H., …Ratcliffe, N. M. (2014). A review of the volatiles from the healthy human body. Journal of Breath Research, 8(1), https://doi.org/10.1088/1752-7155/8/1/014001

A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported. 1840 VOCs have been assigned from breath (872), saliva (359), blood (154), milk (256), skin secretions (532) urin... Read More about A review of the volatiles from the healthy human body.

Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells (2014)
Journal Article
Tezera, L. B., Page, K., Rhakimova, A., Salisbury, V., & Davenport, V. (2014). Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells. Advances in Microbiology, 04(02), 81-93. https://doi.org/10.4236/aim.2014.42013

In this study, we investigate the potential for oral Lactobacilli (LB) to afford innate protection against nasopharyngeal coloniser Neisseria meningitidis serogroup B (NmB), which causes the bulk of UK meningococcal disease. Oral isolates of L. plant... Read More about Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells.

Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients (2014)
Journal Article
Anderson, E., & Salisbury, V. (2014). Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients. Advances in Biochemical Engineering Biotechnology, 145, 189-214. https://doi.org/10.1007/978-3-662-43619-6_6

© Springer-Verlag Berlin Heidelberg 2014. Bioluminescent bacterial biosensors can be used in a rapid in vitro assay to predict sensitivity to commonly used chemotherapy drugs in acute myeloid leukemia (AML). The nucleoside analog cytarabine (ara-C) i... Read More about Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients.

Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662 (2014)
Journal Article
Blackburn, J., Burston, B., Shepherd, S., Bone, H., Blom, A., & Mansell, J. (2014). Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662

Metformin (Met) is a biguanide drug widely used in the treatment and management of non insulin-dependent diabetes mellitus. In recent years it has emerged that Met, by stimulating adenosine monophosphate-activated protein kinase (AMPK), can promote t... Read More about Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662.

Review: 'Social networks and popular understanding of science and health: sharing disparities' by Brian G Southwell (2014)
Journal Article
Grand, A. (2014). Review: 'Social networks and popular understanding of science and health: sharing disparities' by Brian G Southwell. JCOM: Journal of Science Communication, 13(4), R01

In this book, Brian G Southwell discusses how disparities in information-sharing arise and what can be done to alleviate them. In all sorts of ways and for all sorts of reasons, people have always sought to share information among their family and ot... Read More about Review: 'Social networks and popular understanding of science and health: sharing disparities' by Brian G Southwell.

Hydrogen sulfide and cell signaling: Team player or referee? (2014)
Journal Article
Hancock, J. T., Hancock, J. T., & Whiteman, M. (2014). Hydrogen sulfide and cell signaling: Team player or referee?. Plant Physiology and Biochemistry, 78, 37-42. https://doi.org/10.1016/j.plaphy.2014.02.012

Hydrogen sulfide (H2S) has been postulated to be the third gasotransmitter, and along with other reactive compounds such as reactive oxygen species (ROS) and nitric oxide (NO) it is thought to be a key signalling molecule. Enzymes which generate H2S,... Read More about Hydrogen sulfide and cell signaling: Team player or referee?.

Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin? (2014)
Journal Article
Liverani, E., & Paul, C. (2014). Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin?. Receptors & Clinical Investigation, 1(1), https://doi.org/10.14800/rci.25

Adrenomedullin is a vasodilatatory peptide, important during the inflammation process and also able to regulate blood-brain barrier function. Adrenomedullin and its receptors have been shown to be glucocorticoid-dependent in many cell types, includin... Read More about Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin?.

Molecular dynamics simulation of humic substances (2014)
Journal Article
Orsi, M. (2014). Molecular dynamics simulation of humic substances. Chemical and Biological Technologies in Agriculture, 1(1), https://doi.org/10.1186/s40538-014-0010-4

© 2014, Orsi. Humic substances (HS) are complex mixtures of natural organic material which are found almost everywhere in the environment, and particularly in soils, sediments, and natural water. HS play key roles in many processes of paramount impor... Read More about Molecular dynamics simulation of humic substances.

Hb fontainebleau (hba2: C.64g>c) in the united arab emirates (2014)
Journal Article
Turner, A., Sasse, J., & Varadi, A. (2014). Hb fontainebleau (hba2: C.64g>c) in the united arab emirates. Hemoglobin, 38(3), 216-220. https://doi.org/10.3109/03630269.2014.912221

Hb Fontainebleau (HBA2: c.64G>C) is a rare α-globin variant, which has previously been described in only 10 individuals worldwide. We report here 12 additional cases identified in our laboratory. These included the first case of a homozygosity for Hb... Read More about Hb fontainebleau (hba2: C.64g>c) in the united arab emirates.

Parenting for lifelong Health: From South Africa to other low- and middle-income countries (2014)
Journal Article
Ward, C., Mikton, C., Cluver, L., Cooper, P., Gardner, F., Hutchings, J., …Wessels, I. (2014). Parenting for lifelong Health: From South Africa to other low- and middle-income countries

At present there are no parenting programmes that are both evidence-based and affordable for low- and middle-income countries, where the need is the greatest. Parenting for Lifelong Health aims to fill this gap. This article sets the context of viole... Read More about Parenting for lifelong Health: From South Africa to other low- and middle-income countries.

Engaging with strangers and brief encounters: Social scientists and emergent public engagement with science and technology (2014)
Journal Article
Wilkinson, C. (2014). Engaging with strangers and brief encounters: Social scientists and emergent public engagement with science and technology. Bulletin of Science, Technology and Society, 34(3-4), 63-76. https://doi.org/10.1177/0270467614552841

Social scientists operate in a range of roles within the public engagement with science and technology (PEST) agenda. Social scientists strengths in respect to ‘translation’ and ‘intermediary’ skills have captured attention at a time of disciplinary... Read More about Engaging with strangers and brief encounters: Social scientists and emergent public engagement with science and technology.