Skip to main content

Research Repository

See what's under the surface

Advanced Search

Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin?

Liverani, E; Paul, Carolyn

Authors

E Liverani



Abstract

Adrenomedullin is a vasodilatatory peptide, important during the inflammation process and also able to regulate blood-brain barrier function. Adrenomedullin and its receptors have been shown to be glucocorticoid-dependent in many cell types, including primary T cells and the major cellular components of the blood-brain barrier. Considering that the immunosuppressant, glucocorticoids are also well-known to regulate inflammation and blood-brain barrier properties, in this research highlight we review the evidence for glucocorticoid modulation of adrenomedullin secretion and adrenomedullin receptor expression at the glial/endothelial interface during physiological and inflammatory conditions. This view would offer a platform for consideration of new therapeutic options aiming to restore or maintain the blood brain barrier.

Journal Article Type Article
Publication Date Jan 1, 2014
Journal Receptors and Clinical Investigation
Print ISSN 2330-0558
Publisher Smart Science and Technology
Peer Reviewed Peer Reviewed
Volume 1
Issue 1
APA6 Citation Liverani, E., & Paul, C. (2014). Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin?. Receptors & Clinical Investigation, 1(1), https://doi.org/10.14800/rci.25
DOI https://doi.org/10.14800/rci.25
Keywords adrenomedullin, glucocorticoids, blood-brain barrier, RAMPs
Publisher URL http://dx.doi.org/10.14800/rci.25

Files







You might also like



Downloadable Citations

;