Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin?
Liverani, E; Paul, Carolyn
Adrenomedullin is a vasodilatatory peptide, important during the inflammation process and also able to regulate blood-brain barrier function. Adrenomedullin and its receptors have been shown to be glucocorticoid-dependent in many cell types, including primary T cells and the major cellular components of the blood-brain barrier. Considering that the immunosuppressant, glucocorticoids are also well-known to regulate inflammation and blood-brain barrier properties, in this research highlight we review the evidence for glucocorticoid modulation of adrenomedullin secretion and adrenomedullin receptor expression at the glial/endothelial interface during physiological and inflammatory conditions. This view would offer a platform for consideration of new therapeutic options aiming to restore or maintain the blood brain barrier.
Liverani, E., & Paul, C. (2014). Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin?. Receptors & Clinical Investigation, 1(1), https://doi.org/10.14800/rci.25
|Journal Article Type||Article|
|Acceptance Date||Dec 20, 2013|
|Publication Date||Jan 1, 2014|
|Journal||Receptors and Clinical Investigation|
|Publisher||Smart Science and Technology|
|Peer Reviewed||Peer Reviewed|
|Keywords||adrenomedullin, glucocorticoids, blood-brain barrier, RAMPs|
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