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All Outputs (70)

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes (2015)
Journal Article
Van Dam, T. J., Letteboer, S. J., Nguyen, T. M. T., Wheway, G., Schmidts, M., Mans, D. A., …Johnson, C. A. (2015). An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nature Cell Biology, 17(8), 1074-1087. https://doi.org/10.1038/ncb3201

© 2015 Macmillan Publishers Limited. Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of... Read More about An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.

Advancing healthcare sciences through staff, student and service user partnerships (2015)
Journal Article
Rolfe, V. (2015). Advancing healthcare sciences through staff, student and service user partnerships

The reforms to the National Health Service scientific training as part of the Modernising Scientific Careers (MSC) initiative have attempted to streamline the delivery of undergraduate-level education through a core ‘Healthcare Science’ Bachelors pro... Read More about Advancing healthcare sciences through staff, student and service user partnerships.

Thai visitors’ expectations and experiences of explainer interaction within a science museum context (2015)
Journal Article
Sonchaeng, P., Kamolpattana, S., Chen, G., Sonchaen, P., Wilkinson, C., Willey, N., & Bultitude, K. (2015). Thai visitors’ expectations and experiences of explainer interaction within a science museum context. Public Understanding of Science, 24(1), 69-85. https://doi.org/10.1177/0963662514525560

© The Author(s) 2015. In Western literature, there is evidence that museum explainers offer significant potential for enhancing visitors’ learning through influencing their knowledge, content, action, behaviour and attitudes. However, little research... Read More about Thai visitors’ expectations and experiences of explainer interaction within a science museum context.

The voltammetric behaviour of lead at a hand drawn pencil electrode and its trace determination in water by stripping voltammetry (2015)
Journal Article
Honeychurch, K. C. (2015). The voltammetric behaviour of lead at a hand drawn pencil electrode and its trace determination in water by stripping voltammetry. Analytical Methods, 7(6), 2437-2443. https://doi.org/10.1039/c4ay02987a

© The Royal Society of Chemistry 2015. This is the first reported proof of concept application of pencil drawn electrodes (PDEs) for anodic stripping voltammetric determination of Pb2+ or any metal ion. PDEs offer advantages of economics, simplicity... Read More about The voltammetric behaviour of lead at a hand drawn pencil electrode and its trace determination in water by stripping voltammetry.

The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation (2015)
Journal Article
Wilson, I., Ciuzan, O., Hancock, J. T., Pamfil, D., Wilson, I. D., & Ladomery, M. (2015). The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation. Physiologia Plantarum, 153(1), 1-11. https://doi.org/10.1111/ppl.12286

© 2014 Scandinavian Plant Physiology Society. The class IV glycine-rich RNA-binding proteins are a distinct subgroup within the heterogenous superfamily of glycine-rich proteins (GRPs). They are distinguished by the presence of an RNA-binding domain... Read More about The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation.

Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity (2015)
Journal Article
Hull, J., Patel, V., El Hindy, M., Lee, C., Odeleye, E., Hezwani, M., …Conway, M. (2015). Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity. Journal of Alzheimer's Disease, 45(3), 891-905. https://doi.org/10.3233/JAD-142970

© 2015 - IOS Press and the authors. All rights reserved. Background: The human branched chain aminotransferases (hBCATm, mitochondrial and hBCATc, cytosolic) are major contributors to brain glutamate production. This excitatory neurotransmitter is th... Read More about Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity.

Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis (2015)
Journal Article
Ouden, K. D., Van Balkom, B. W., Slaats, G. G., Wheway, G., Foletto, V., Szymanska, K., …Giles, R. H. (2015). Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis. Journal of Cell Science, 128(24), 4550-4559. https://doi.org/10.1242/jcs.176065

©2015. To investigate the contribution of ion channels to ciliogenesis, we carried out a small interfering RNA (siRNA)-based reverse genetics screen of all ion channels in the mouse genome in murine inner medullary collecting duct kidney cells. This... Read More about Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis.

Open science (2015)
Journal Article
Grand, A. (2015). Open science. JCOM: Journal of Science Communication, 14(4),

Open science is the most recent paradigm shift in the practice of science. However, it is a practice that has emerged relatively recently and as such, its definition is constantly-shifting and evolving. This commentary describes the historical backgr... Read More about Open science.

Chromosomal ampC mutations in cefpodoxime-resistant, ESBL-negative uropathogenic Escherichia coli (2015)
Journal Article
Lawrance, L. M., Arnold, D. L., Moore, P. C., Lewis, J. A., Moore, P. M., Arnold, D. L., & Lawrance, L. (2015). Chromosomal ampC mutations in cefpodoxime-resistant, ESBL-negative uropathogenic Escherichia coli. British Journal of Biomedical Science, 72(1), 7-11. https://doi.org/10.1080/09674845.2015.11666789

AmpC β-lactamase is an enzyme commonly produced by Escherichia coli that causes resistance to cephalosporins and penicillins. Enzyme production is controlled by the strength of the promoter encoded by the chromosomal ampC gene, with the level of prod... Read More about Chromosomal ampC mutations in cefpodoxime-resistant, ESBL-negative uropathogenic Escherichia coli.