All Outputs (87)

Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial (2019)
Journal Article
Hartshorn, S., Barrett, M. J., Lyttle, M. D., Yee, S. A., & Irvine, A. T. (2019). Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial. Trials, 20, Article 393 (2019). https://doi.org/10.1186/s13063-019-3511-4

Background Pain from injuries is one of the commonest symptoms in children attending emergency departments (EDs), and this is often inadequately treated in both the pre-hospital and ED settings, in part due to challenges of continual assessment and... Read More about Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial.

Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland (2019)
Journal Article
Jahn, H. K., Jahn, I. H., Roland, D., Lyttle, M. D., & Behringer, W. (2019). Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland. Archives of Disease in Childhood, 104(12), 1203-1207. https://doi.org/10.1136/archdischild-2019-316872

Introduction Mobile devices and medical apps are used by healthcare professionals in adult and paediatric emergency departments worldwide. Recently, there has been a drive toward increased digitalisation especially in the UK. This point prevalence su... Read More about Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland.

Training and delivery of a novel fatigue intervention: a qualitative study of rheumatology health-care professionals' experiences (2019)
Journal Article
Dures, E., Rooke, C., Hammond, A., & Hewlett, S. (2019). Training and delivery of a novel fatigue intervention: a qualitative study of rheumatology health-care professionals' experiences. Rheumatology Advances in Practice, 3(2), 1-7. https://doi.org/10.1093/rap/rkz032

Objectives. Successful, non-pharmacological research interventions are challenging to implement in clinical practice. The aim of the study was to understand the experiences of rheumatology nurses and occupational therapists (tutors) delivering a nove... Read More about Training and delivery of a novel fatigue intervention: a qualitative study of rheumatology health-care professionals' experiences.

Anaesthetic–analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: The CEDAR RCT (2019)
Journal Article
Moore, M. V., Lyttle, M. D., Blair, P. S., Thomas, T. E., Harris, S. D., Francis, N. A., …Little, P. (2019). Anaesthetic–analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: The CEDAR RCT. Health Technology Assessment, 23(34), vii-47. https://doi.org/10.3310/hta23340

© Queen’s Printer and Controller of HMSO 2019. Background: Acute otitis media (AOM) is a common reason for primary care consultations and antibiotic prescribing in children. Options for improved pain control may influence antibiotic prescribing and c... Read More about Anaesthetic–analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: The CEDAR RCT.

Systematic exploration of local reviews of the care of maternal deaths in the UK and Ireland between 2012 and 2014: A case note review study (2019)
Journal Article
Cross-Sudworth, F., Knight, M., Goodwin, L., & Kenyon, S. (2019). Systematic exploration of local reviews of the care of maternal deaths in the UK and Ireland between 2012 and 2014: A case note review study. BMJ Open, 9, Article e029552. https://doi.org/10.1136/bmjopen-2019-029552

Objectives Local reviews of the care of women who die in pregnancy and post-birth should be undertaken. We investigated the quantity and quality of hospital reviews. Design Anonymised case notes review. Participants All 233 women in the UK and... Read More about Systematic exploration of local reviews of the care of maternal deaths in the UK and Ireland between 2012 and 2014: A case note review study.

A cross-country time and motion study to measure the impact of electronic medication management systems on the work of hospital pharmacists in Australia and England (2019)
Journal Article
Westbrook, J. I., Li, L., Shah, S., Lehnbom, E. C., Prgomet, M., Schofield, B., …Sheikh, A. (2019). A cross-country time and motion study to measure the impact of electronic medication management systems on the work of hospital pharmacists in Australia and England. International Journal of Medical Informatics, 129, 253-259. https://doi.org/10.1016/j.ijmedinf.2019.06.011

© 2019 Background: Qualitative studies have provided important insights into how hospital pharmacists’ work changes when electronic medication management (EMM) systems are introduced. Quantitative studies of work practice change are rare. Despite the... Read More about A cross-country time and motion study to measure the impact of electronic medication management systems on the work of hospital pharmacists in Australia and England.

A systematic review of asylum-seeking women's views and experiences of UK maternity care (2019)
Journal Article
McKnight, P., Goodwin, L., & Kenyon, S. (2019). A systematic review of asylum-seeking women's views and experiences of UK maternity care. Midwifery, 77, 16-23. https://doi.org/10.1016/j.midw.2019.06.007

Objective To explore and synthesise evidence of asylum-seeking women's experiences of maternity care in the UK. Design A systematic review and thematic synthesis of peer-reviewed qualitative evidence. Relevant databases were searched from 2000 u... Read More about A systematic review of asylum-seeking women's views and experiences of UK maternity care.

Telephone outreach by community workers to improve uptake of NHS Health Checks in more deprived localities and minority ethnic groups: A qualitative investigation of implementation (2019)
Journal Article
Stone, T., Brangan, E., Chappell, A., Harrison, V., & Horwood, J. (2020). Telephone outreach by community workers to improve uptake of NHS Health Checks in more deprived localities and minority ethnic groups: A qualitative investigation of implementation. Journal of Public Health, 42(2), e198-e206. https://doi.org/10.1093/pubmed/fdz063

BACKGROUND: NHS Health Checks is a national cardiovascular risk assessment and management programme in England. To improve equity of uptake in more deprived, and Black, Asian and minority ethnic (BAME) communities, a novel telephone outreach interven... Read More about Telephone outreach by community workers to improve uptake of NHS Health Checks in more deprived localities and minority ethnic groups: A qualitative investigation of implementation.

Where Should Critically Ill Adolescents Receive Care? A Qualitative Interview-Based Study of Perspectives of Staff Working in Adult and Pediatric Intensive Care Units (2019)
Journal Article
Wood, D., Geoghegan, S., Ramnarayan, P., Davis, P. J., Tume, L., Pappachan, J. V., …Wray, J. (2020). Where Should Critically Ill Adolescents Receive Care? A Qualitative Interview-Based Study of Perspectives of Staff Working in Adult and Pediatric Intensive Care Units. Journal of Intensive Care Medicine, 35(11), 1271-1277. https://doi.org/10.1177/0885066619856573

Purpose: In the United Kingdom, critically ill adolescents are treated in either adult or pediatric intensive care units (AICUs or PICUs). This study explores staff perspectives on where and how best to care for this distinct group. Materials and Met... Read More about Where Should Critically Ill Adolescents Receive Care? A Qualitative Interview-Based Study of Perspectives of Staff Working in Adult and Pediatric Intensive Care Units.

Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis (2019)
Journal Article
Woolfall, K., O'Hara, C., Deja, E., Canter, R., Khan, I., Mouncey, P., …Inwald, D. (2019). Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis. Archives of Disease in Childhood, 104(11), 1077-1082. https://doi.org/10.1136/archdischild-2019-316807

Objective: To identify parents' prioritised outcomes by combining qualitative findings from two trial feasibility studies of interventions for paediatric suspected severe infection. Design: Qualitative synthesis combining parent interview data from t... Read More about Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis.

Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis (2019)
Journal Article
Jamal, A., Finkelstein, Y., Kuppermann, N., Freedman, S. B., Florin, T. A., Babl, F. E., …Schuh, S. (2019). Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis. Lancet Child and Adolescent Health, 3(8), 539-547. https://doi.org/10.1016/s2352-4642%2819%2930193-2

Background Clinical guidelines advise against pharmacotherapy in bronchiolitis. However, little is known about global variation in prescribing practices for bronchiolitis at discharge from emergency departments. We aimed to evaluate global variation... Read More about Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis.

Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC) (2019)
Journal Article
Waterfield, T., Lyttle, M. D., Shields, M., Fairley, D., Roland, D., McKenna, J., & Woolfall, K. (2019). Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC). Archives of Disease in Childhood, 104(10), 979-983. https://doi.org/10.1136/archdischild-2019-317117

Objective: The Petechiae in Children (PiC) study assesses the utility of presenting features and rapid diagnostic tests in the diagnosis of serious bacterial infection in feverish children with non-blanching rashes. An embedded qualitative study expl... Read More about Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC).

Real-world ethics in palliative care: Protocol for a systematic review of the ethical challenges reported by specialist palliative care practitioners in their clinical practice (2019)
Journal Article
Schofield, G., Brangan, E., Dittborn, M., Huxtable, R., & Selman, L. (2019). Real-world ethics in palliative care: Protocol for a systematic review of the ethical challenges reported by specialist palliative care practitioners in their clinical practice. BMJ Open, 9, e028480. https://doi.org/10.1136/bmjopen-2018-028480

Introduction Ethical issues arise daily in the delivery of palliative care. Despite much (largely theoretical) literature, evidence from specialist palliative care practitioners (SPCPs) about real-world ethical challenges has not previously been syn... Read More about Real-world ethics in palliative care: Protocol for a systematic review of the ethical challenges reported by specialist palliative care practitioners in their clinical practice.

Exploring the determinants of mobile health adoption by hospitals in China: Empirical study (2019)
Journal Article
Ramdani, B., Duan, B., & Berrou, I. (2020). Exploring the determinants of mobile health adoption by hospitals in China: Empirical study. JMIR Medical Informatics, 8(7), Article e14795. https://doi.org/10.2196/14795

Background: Although mobile health (mHealth) has the potential to transform health care by delivering better outcomes at a much lower cost than traditional health care services, little is known about mHealth adoption by hospitals. Objective: Thi... Read More about Exploring the determinants of mobile health adoption by hospitals in China: Empirical study.

Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development (2019)
Journal Article
Trefan, L., Akbari, A., Paranjothy, S., Farewell, D. M., Gartner, A., Fone, D., …Moore, S. (2019). Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development. International Journal of Population Data Science, 4(1), https://doi.org/10.23889/ijpds.v4i1.581

Introduction: Excessive alcohol consumption has adverse effects on health and there is a recognised need for the longitudinal analysis of population data to improve our understanding of the patterns of alcohol use, harms to consumers and those in the... Read More about Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development.

Midwives’ perspectives of continuity based working in the UK: A cross-sectional survey (2019)
Journal Article
Taylor, B., Cross-Sudworth, F., Goodwin, L., Kenyon, S., & MacArthur, C. (2019). Midwives’ perspectives of continuity based working in the UK: A cross-sectional survey. Midwifery, 75, 127-137. https://doi.org/10.1016/j.midw.2019.05.005

Objective: UK policy is advocating continuity of midwife throughout the antenatal, intrapartum and postnatal period in order to improve outcomes. We explored the working patterns that midwives are willing and able to adopt, barriers to change, and wh... Read More about Midwives’ perspectives of continuity based working in the UK: A cross-sectional survey.

Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: A systematic review (2019)
Journal Article
Trubey, R., Huang, C., Lugg-Widger, F. V., Hood, K., Allen, D., Edwards, D., …Powell, C. (2019). Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: A systematic review. BMJ Open, 9(5), https://doi.org/10.1136/bmjopen-2018-022105

Objective: To assess (1) how well validated existing paediatric track and trigger tools (PTTT) are for predicting adverse outcomes in hospitalised children, and (2) how effective broader paediatric early warning systems are at reducing adverse outcom... Read More about Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: A systematic review.

Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT) (2019)
Journal Article
Lyttle, M. D., Bielicki, J. A., Barratt, S., Dunn, D., Finn, A., Harper, L., …Sharland, M. (2019). Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT). BMJ Open, 9(5), e029875. https://doi.org/10.1136/bmjopen-2019-029875

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Introduction Community-acquired pneumonia (CAP) is a common indication for antibiotic treatment in young children. Data are limited regarding the ideal dose and... Read More about Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT).

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial (2019)
Journal Article
Crome, L., Nyirenda, M., Sajjanhar, T., Leighton, S., McLellan, S., Bell, C., …Lyttle, M. D. (2019). Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet, 393(10186), 2125-2134. https://doi.org/10.1016/S0140-6736%2819%2930724-X

Background Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This... Read More about Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.

Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis (2019)
Journal Article
Ovadia, C., Perdones‐Montero, A., Spagou, K., Smith, A., Sarafian, M. H., Gomez‐Romero, M., …Williamson, C. (2019). Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis. Hepatology, 70(1), 276-293. https://doi.org/10.1002/hep.30661

Pregnancy is associated with progressive hypercholanemia, hypercholesterolemia, and hypertriglyceridemia, which can result in metabolic disease in susceptible women. Gut signals modify hepatic homeostatic pathways, linking intestinal content to metab... Read More about Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis.