All Outputs (89)

Interaction between leukaemic cells and the bone marrow stroma (2020)
Thesis
Gynn, L. Interaction between leukaemic cells and the bone marrow stroma. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6037712

Mesenchymal stromal cells (MSC) enhance growth and protect leukaemic cells from drug-induced toxicity in the bone marrow microenvironment (BMM), however, these interactions are not fully understood and less is known about the impact of leukaemic cell... Read More about Interaction between leukaemic cells and the bone marrow stroma.

The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades (2020)
Thesis
Shafei, M. The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3429539

Introduction and Aims: Breast cancer remains the leading cause of cancer mortality in women globally, despite advances in the development of targeted therapies. Driven by oncogenic signals, cancer cells undergo metabolic reprogramming, upregulatin... Read More about The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades.

Regulation of neurotransmitter synthesis in Alzheimer's disease - Potential for novel disease biomarkers (2020)
Thesis
Hudd, F. Regulation of neurotransmitter synthesis in Alzheimer's disease - Potential for novel disease biomarkers. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3566872

Introduction: There currently is an unmet need for new diagnostics to monitor Alzheimer’s disease (AD) and a lack of understanding of the metabolic processes, in particular leucine deprivation on disease and the autophagy pathway. It is thought that... Read More about Regulation of neurotransmitter synthesis in Alzheimer's disease - Potential for novel disease biomarkers.

Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways (2020)
Thesis
Okoro, G. U. Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1491050

Introduction and aims: Alzheimer’s disease (AD) has for decades been associated with increased accumulation of brain amyloid β peptides (Aβ) and phosphorylated tau. Unfortunately, targeted therapy to Aβ in particular has not been successful resulting... Read More about Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways.

Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia (2020)
Thesis
Fombon, I. Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3829730

Introduction and aims: Fenofibrate is the most widely used fibric acid derivative for managing mixed dyslipidaemia, characterised by elevated levels of cholesterol, triglycerides and LDL cholesterol and low levels of HDL cholesterol. Fenofibrate is a... Read More about Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia.

Investigations into the design and development of novel screenprinted electrochemical biosensors for sugars (2020)
Thesis
Nicholas, P. Investigations into the design and development of novel screenprinted electrochemical biosensors for sugars. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490862

The aim of the studies described in this thesis was to develop a set of single shot biosensors, for low concentration measures (less the 1 mM) of glucose, sucrose and fructose. In addition, the development of a user friendly potentiostat instrumental... Read More about Investigations into the design and development of novel screenprinted electrochemical biosensors for sugars.

Understanding the psychosocial impact of Joint Hypermobility and Ehlers-Danlos Syndrome (2020)
Thesis
Bennett, S. Understanding the psychosocial impact of Joint Hypermobility and Ehlers-Danlos Syndrome. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/4522950

Abstract Introduction: Joint Hypermobility Syndrome (JHS) and Ehlers-Danlos Syndrome Hypermobility Type (EDS-HT) are heritable disorders affecting connective tissue. Existing research has predominately focused on biological features such as joint... Read More about Understanding the psychosocial impact of Joint Hypermobility and Ehlers-Danlos Syndrome.

In vitro modelling of tongue derived microbial biofilms and their reponse to treatment (2020)
Thesis
Hewett, K. E. In vitro modelling of tongue derived microbial biofilms and their reponse to treatment. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1491292

This work concerns the development of a flat plate perfusion model to study biofilms derived from human tongue biota. The model has been derived from a previous sorbarod model, via a flat plate model (used to study wound organisms), to the model desc... Read More about In vitro modelling of tongue derived microbial biofilms and their reponse to treatment.

Targeting the splice factor kinase CLK1 in prostate cancer cells (2020)
Thesis
Uzor, S. O. Targeting the splice factor kinase CLK1 in prostate cancer cells. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490733

Prostate cancer is the most rampant diagnosed cancer and the second leading cause of cancer related death in men between middle age and old age. There is a need to identify the molecular genetic processes that underpin prostate cancer and to search f... Read More about Targeting the splice factor kinase CLK1 in prostate cancer cells.

Antimicrobial activity of essential oils as liquid and vapour applications (2020)
Thesis
Elcocks, E. R. (2020). Antimicrobial activity of essential oils as liquid and vapour applications. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490727

Essential oils produced by plants have been used as antimicrobial agents historically, however, many essential oils remain under-exploited as alternatives to antimicrobials. Therefore, the aim of this thesis was to evaluate the antibacterial efficacy... Read More about Antimicrobial activity of essential oils as liquid and vapour applications.

An in vitro investigation of microbial volatile analysis for diagnosis of wound infection (2019)
Thesis
Slade, E. An in vitro investigation of microbial volatile analysis for diagnosis of wound infection. (Thesis). UWE. Retrieved from https://uwe-repository.worktribe.com/output/4917997

Microorganisms produce a wide range of volatile compounds as a product of metabolism. As a result of their different metabolic capabilities, the profiles of volatiles produced will differ between species. This research investigates the detection of v... Read More about An in vitro investigation of microbial volatile analysis for diagnosis of wound infection.

The development of point-of-use treatment technologies for the production of drinking water (2019)
Thesis
Clayton, G. The development of point-of-use treatment technologies for the production of drinking water. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490721

An estimated 884 million people worldwide lack access to drinking water from improved water sources. With the global population expected to reach eleven billion by the end of the 21st Century, stress on water and energy resources will be exacerbated.... Read More about The development of point-of-use treatment technologies for the production of drinking water.

New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories (2019)
Thesis
Fraser, M. A. New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490747

Candidaemia is widely reported as the fourth most common form of bloodstream infection worldwide. Reports of cases of candidaemia whilst patients are in receipt of antifungal therapy are increasing, and this is especially relevant as prescribing prac... Read More about New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories.

Developmental, morphological and physiological effects of chronic low doses of ionising radiation on plants on earth and in space (2019)
Thesis
Caplin, N. M. Developmental, morphological and physiological effects of chronic low doses of ionising radiation on plants on earth and in space. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1491172

Conclusions in the current literature are essentially unanimous regarding what is known about the effects of ionising radiation on plants. It is agreed that acute high-dose effects (primarily from laboratory tests) are well-documented and understood... Read More about Developmental, morphological and physiological effects of chronic low doses of ionising radiation on plants on earth and in space.

Suicide and its discontent: Practitioner psychologists experiences of working with active suicidal ideation (2019)
Thesis
Llewellyn, S. Suicide and its discontent: Practitioner psychologists experiences of working with active suicidal ideation. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1491233

Suicide is often conceptualised as a harmful, frightening and a misunderstood phenomenon. Research has shown that the theorising of suicide is broad-ranging and complex identifying that working clinically with clients who present with suicide can be... Read More about Suicide and its discontent: Practitioner psychologists experiences of working with active suicidal ideation.

An investigation into the regulation of transcription of the splice factor kinase gene SRPK1 in prostate and leukaemia cancer cell lines (2019)
Thesis
Belali, T. An investigation into the regulation of transcription of the splice factor kinase gene SRPK1 in prostate and leukaemia cancer cell lines. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490649

The SRPK1 gene encodes a protein kinase that phosphorylates a class of splice factors called serine/arginine-rich proteins (SR proteins) modifying their ability to regulate alternative pre-mRNA splicing. Studies have linked high SRPK1 levels to tumou... Read More about An investigation into the regulation of transcription of the splice factor kinase gene SRPK1 in prostate and leukaemia cancer cell lines.

The role of ABA in regulating the movemement of chlamydomonas reinhardtii in response to stress (2019)
Thesis
Alhijab, L. The role of ABA in regulating the movemement of chlamydomonas reinhardtii in response to stress. (Thesis). The West England University. Retrieved from https://uwe-repository.worktribe.com/output/1492927

Plant hormones such as auxin, gibberellin, cytokinin, ethylene, and abscisic acid play key roles in growth and developmental processes in higher plants such as Arabidopsis thaliana. However, the effect of these hormones on algal physiology is still u... Read More about The role of ABA in regulating the movemement of chlamydomonas reinhardtii in response to stress.

Bird's nest ferns as model systems and conservation tools (2019)
Thesis
Phillips, J. Bird's nest ferns as model systems and conservation tools. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/846445

We are in a race against time to understand the response of natural systems to climate change and anthropogenic disturbances, such as large scale land conversion for oil palm expansion. However, it is incredibly difficult to quantify multi-trophic bi... Read More about Bird's nest ferns as model systems and conservation tools.

What influences adherence to treatment in people with multiple sclerosis? (2019)
Thesis
Moloney, C. H. What influences adherence to treatment in people with multiple sclerosis?. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/850513

Background Currently, there are a number of disease modifying therapies (DMTs) available that can help to reduce the number of attacks experienced in relapsing remitting multiple sclerosis (RRMS). However, optimal outcomes are not always achieved du... Read More about What influences adherence to treatment in people with multiple sclerosis?.

Investigations into novel electrochemical technology for boar taint detection and vitamin analysis (2019)
Thesis
Westmacott, K. Investigations into novel electrochemical technology for boar taint detection and vitamin analysis. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/853351

This thesis presents the evaluation of the novel electrochemical sensor and biosensor technology developed for the direct analysis of boar taint compounds in adipose tissue (European Patent 2966441). Gas chromatographic methods and extraction procedu... Read More about Investigations into novel electrochemical technology for boar taint detection and vitamin analysis.