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All Outputs (103)

Cluster-randomized controlled trial evaluating the effectiveness of computer-assisted intervention delivered by educators for children with speech sound disorders (2017)
Journal Article
Howland, C., McLeod, S., Baker, E., McCormack, J., Wren, Y., Roulstone, S., …White, P. (2017). Cluster-randomized controlled trial evaluating the effectiveness of computer-assisted intervention delivered by educators for children with speech sound disorders. Journal of Speech, Language, and Hearing Research, 60(7), 1891-1910. https://doi.org/10.1044/2017_JSLHR-S-16-0385

© 2017 American Speech-Language-Hearing Association. Purpose: The aim was to evaluate the effectiveness of computer-assisted input-based intervention for children with speech sound disorders (SSD). Method: The Sound Start Study was a cluster-randomiz... Read More about Cluster-randomized controlled trial evaluating the effectiveness of computer-assisted intervention delivered by educators for children with speech sound disorders.

Test statistics for the comparison of means for two samples that include both paired and independent observations (2017)
Journal Article
Derrick, B., Russ, B., Toher, D., & White, P. (2017). Test statistics for the comparison of means for two samples that include both paired and independent observations. Journal of modern applied statistical methods : JMASM, 16(1), 137-157. https://doi.org/10.22237/jmasm/1493597280

©2017 JMASM, Inc. Standard approaches for analyzing the difference in two means, where partially overlapping samples are present, are less than desirable. Here are introduced two test statistics, making reference to the t-distribution. It is shown th... Read More about Test statistics for the comparison of means for two samples that include both paired and independent observations.

How to compare the means of two samples that include paired observations and independent observations: A companion to Derrick, Russ, Toher and White (2017) (2017)
Journal Article
Derrick, B., Toher, D., & White, P. (2017). How to compare the means of two samples that include paired observations and independent observations: A companion to Derrick, Russ, Toher and White (2017). Quantitative Methods for Psychology, 13(2), 120-126. https://doi.org/10.20982/tqmp.13.2.p120

Standard approaches for comparing the means of two samples, comprising both paired observations and independent observations, involve the discarding of valuable information. An alternative test which uses all of the available data, is the partially o... Read More about How to compare the means of two samples that include paired observations and independent observations: A companion to Derrick, Russ, Toher and White (2017).

A comparison of analytical methods for the two group pre- post design (2017)
Presentation / Conference
Allis, V., & White, P. (2017, April). A comparison of analytical methods for the two group pre- post design. Poster presented at UWE Student Conference, Bristol, England

Simulation demonstrates that for a two group randomized design ANCOVA is more powerful than the gain score approach For ANCOVA with an interaction term the model with pre scores X as a covariate is more powerful than the model with X + Y as the co... Read More about A comparison of analytical methods for the two group pre- post design.

Protocol for a randomized, double blind, placebo controlled, crossover trial of Melatonin for treatment of Nocturia in adults with Multiple Sclerosis (MeNiMS) (2017)
Journal Article
Delgado, D., Canham, L., Cotterill, N., Cottrell, D., Drake, M. J., Inglis, K., …White, P. (2017). Protocol for a randomized, double blind, placebo controlled, crossover trial of Melatonin for treatment of Nocturia in adults with Multiple Sclerosis (MeNiMS). BMC Neurology, 17(1), https://doi.org/10.1186/s12883-017-0845-y

© 2017 The Author(s). Background: Nocturia (the symptom of needing to wake up to pass urine) is common in progressive Multiple Sclerosis (MS) patients. Moderate-to-severe nocturia affects quality of life, can exacerbate fatigue and may affect capacit... Read More about Protocol for a randomized, double blind, placebo controlled, crossover trial of Melatonin for treatment of Nocturia in adults with Multiple Sclerosis (MeNiMS).

The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH-wildtype primary glioblastoma (2016)
Journal Article
Singleton, W. G., Haynes, H. R., White, P., Hares, K. M., Redondo, J., Kemp, K. C., …Kurian, K. M. (2017). The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH-wildtype primary glioblastoma. Histopathology, 70(7), 1030-1043. https://doi.org/10.1111/his.13142

© 2016 John Wiley & Sons Ltd Aims: PPARα agonists are in current clinical use as hypolipidaemic agents and show significant antineoplastic effects in human glioblastoma models. To date however, the expression of PPARα in large-scale glioblastoma da... Read More about The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH-wildtype primary glioblastoma.

The use of a gas chromatography-sensor system combined with advanced statistical methods, towards the diagnosis of urological malignancies (2016)
Journal Article
Aggio, R. B. M., De Lacy Costello, B., White, P., Khalid, T., Ratcliffe, N. M., Persad, R., & Probert, C. S. J. (2016). The use of a gas chromatography-sensor system combined with advanced statistical methods, towards the diagnosis of urological malignancies. Journal of Breath Research, 10(1), https://doi.org/10.1088/1752-7155/10/1/017106

© 2016 IOP Publishing Ltd. Prostate cancer is one of the most common cancers. Serum prostate-specific antigen (PSA) is used to aid the selection of men undergoing biopsies. Its use remains controversial. We propose a GC-sensor algorithm system for cl... Read More about The use of a gas chromatography-sensor system combined with advanced statistical methods, towards the diagnosis of urological malignancies.

Why Welch’s test is Type I error robust (2016)
Journal Article
Derrick, B., Toher, D., & White, P. (2016). Why Welch’s test is Type I error robust. Quantitative Methods for Psychology, 12(1), 30-38

The comparison of two means is one of the most commonly applied statistical procedures in psychology. The independent samples t-test corrected for unequal variances is commonly known as Welch’s test, and is widely considered to be a robust alternativ... Read More about Why Welch’s test is Type I error robust.

Test statistics for comparing two proportions with partially overlapping samples (2015)
Journal Article
Derrick, B., Dobson-Mckittrick, A., Toher, D., & White, P. (2015). Test statistics for comparing two proportions with partially overlapping samples. Journal of Applied Quantitative Methods, 10(3),

Standard tests for comparing two sample proportions of a dichotomous dependent variable where there is a combination of paired and unpaired samples are considered. Four new tests are introduced and compared against standard tests and an alternative p... Read More about Test statistics for comparing two proportions with partially overlapping samples.

Cardiopulmonary reserve as determined by cardiopulmonary exercise testing correlates with length of stay and predicts complications after radical cystectomy (2015)
Journal Article
Darweish, A., Tolchard, S., Angell, J., Pyke, M., Lewis, S., Dodds, N., …Gillatt, D. (2015). Cardiopulmonary reserve as determined by cardiopulmonary exercise testing correlates with length of stay and predicts complications after radical cystectomy. BJU International, 115(4), 554-561. https://doi.org/10.1111/bju.12895

© 2014 The Authors. BJU International © 2014 BJU International. ObjectiveTo investigate whether poor preoperative cardiopulmonary reserve and comorbid state dictate high-risk status and can predict complications in patients undergoing radical cystect... Read More about Cardiopulmonary reserve as determined by cardiopulmonary exercise testing correlates with length of stay and predicts complications after radical cystectomy.

The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication (2015)
Journal Article
Lowndes, S. A., White, P., Hooper, C. E., Lyburn, I. D., Searle, J., Darby, M., …Maskell, N. A. (2015). The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication. British Journal of Cancer, 112(7), 1175-1182. https://doi.org/10.1038/bjc.2015.62

© 2015 Cancer Research UK. All rights reserved. Background: Robust markers that predict prognosis and detect early treatment response in malignant pleural mesothelioma (MPM) would enhance patient care. Methods: Consecutive patients with MPM who were... Read More about The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication.

A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: A proof of principle pilot study (2015)
Journal Article
Maskell, N. A., Kahan, B. C., Lyen, S. M., Sequeiros, I., Braybrooke, J. P., Morley, A. J., …Maskell, N. A. (2015). A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: A proof of principle pilot study. PLoS ONE, 10(3), https://doi.org/10.1371/journal.pone.0118569

© 2015 Clive et al. Introduction: Animal studies have shown Zoledronic Acid (ZA) may diminish pleural fluid accumulation and tumour bulk in malignant pleural disease (MPD). We performed a pilot study to evaluate its effects in humans. Methods: We und... Read More about A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: A proof of principle pilot study.

The effect of chemotherapy on health-related quality of life in mesothelioma: Results from the SWAMP trial (2015)
Journal Article
Arnold, D. T., Hooper, C. E., Morley, A., White, P., Lyburn, I. D., Searle, J., …Maskell, N. A. (2015). The effect of chemotherapy on health-related quality of life in mesothelioma: Results from the SWAMP trial. British Journal of Cancer, 112(7), 1183-1189. https://doi.org/10.1038/bjc.2015.77

© 2015 Cancer Research UK. All rights reserved. Background: The effect of chemotherapy on health-related quality of life (HRQoL) in malignant pleural mesothelioma (MPM) is poorly understood. Patient-individualised prognostication and prediction of tr... Read More about The effect of chemotherapy on health-related quality of life in mesothelioma: Results from the SWAMP trial.

Predictive value of abnormally raised serum bilirubin in acute appendicitis: A cohort study (2015)
Journal Article
White, P., Chambers, A. C., Bismohun, S. L., Davies, H., White, P., & Patil, A. V. (2015). Predictive value of abnormally raised serum bilirubin in acute appendicitis: A cohort study. International Journal of Surgery, 13, 207-210. https://doi.org/10.1016/j.ijsu.2014.11.041

© 2014 Surgical Associates Ltd. Appendicitis is a common clinical diagnosis aided by biochemical, haematological and radiological investigations. The role of some investigations, such as bilirubin, is controversial but could indicate complicated appe... Read More about Predictive value of abnormally raised serum bilirubin in acute appendicitis: A cohort study.

EGFR and EGFRvIII analysis in glioblastoma as therapeutic biomarkers (2015)
Journal Article
Kurian, K. M., DeSouza, R. M., Haynes, H. R., Faulkner, C., Palmer, A., Williams, H., …Kurian, K. M. (2015). EGFR and EGFRvIII analysis in glioblastoma as therapeutic biomarkers. British Journal of Neurosurgery, 29(1), 23-29. https://doi.org/10.3109/02688697.2014.950631

Copyright © 2014 The Neurosurgical Foundation. Introduction. EGFR and EGFRvIII analysis is of current interest because of new EGFRvIII vaccine trials opened in the UK. EGFR activation promotes cellular proliferation via activation of MAPK and PI3K-Ak... Read More about EGFR and EGFRvIII analysis in glioblastoma as therapeutic biomarkers.

Pleural irrigation trial (PIT): A randomised controlled trial of pleural irrigation with normal saline versus standard care in patients with pleural infection (2015)
Journal Article
Maskell, N. A., Zahan-Evans, N., Harvey, J. E., Medford, A. R., Clive, A. O., Edey, A. J., …Maskell, N. A. (2015). Pleural irrigation trial (PIT): A randomised controlled trial of pleural irrigation with normal saline versus standard care in patients with pleural infection. European Respiratory Journal, 46(2), 456-463. https://doi.org/10.1183/09031936.00147214

© ERS 2015. Pleural infection is increasing in incidence. Despite optimal medical management, up to 30% of patients will die or require surgery. Case reports suggest that irrigation of the pleural space with saline may be beneficial. A randomised con... Read More about Pleural irrigation trial (PIT): A randomised controlled trial of pleural irrigation with normal saline versus standard care in patients with pleural infection.

BRAF Fusion Analysis in Pilocytic Astrocytomas: KIAA1549-BRAF 15-9 Fusions Are More Frequent in the Midline Than Within the Cerebellum (2015)
Journal Article
Faulkner, C., Ellis, H. P., Shaw, A., Penman, C., Palmer, A., Wragg, C., …Kurian, K. M. (2015). BRAF Fusion Analysis in Pilocytic Astrocytomas: KIAA1549-BRAF 15-9 Fusions Are More Frequent in the Midline Than Within the Cerebellum. Journal of Neuropathology and Experimental Neurology, 74(9), 867-872. https://doi.org/10.1097/NEN.0000000000000226

Copyright © 2015 by the American Association of Neuropathologists, Inc. Pilocytic astrocytomas (PAs) are increasingly tested for KIAA1549-BRAF fusions. We used reverse transcription polymerase chain reaction for the 3 most common KIAA1549-BRAF fusion... Read More about BRAF Fusion Analysis in Pilocytic Astrocytomas: KIAA1549-BRAF 15-9 Fusions Are More Frequent in the Midline Than Within the Cerebellum.

The psychological well-being and appearance concerns of patients presenting with ptosis (2014)
Journal Article
White, P., Rumsey, N., Jenkinson, E., Richards, H. S., Jenkinson, E., Rumsey, N., …Harrad, R. A. (2014). The psychological well-being and appearance concerns of patients presenting with ptosis. Eye, 28(3), 296-302. https://doi.org/10.1038/eye.2013.264

PurposePtosis affects both the function and appearance of the eyes and face, because of drooping of the eyelids. Previous research has focused on functional impairment; however, similar appearance altering eye conditions have been demonstrated to hav... Read More about The psychological well-being and appearance concerns of patients presenting with ptosis.

Operative time and outcome of enhanced recovery after surgery after laparoscopic colorectal surgery (2014)
Journal Article
Harrison, O. J., Smart, N. J., White, P., Brigic, A., Carlisle, E. R., Allison, A. S., …Francis, N. K. (2014). Operative time and outcome of enhanced recovery after surgery after laparoscopic colorectal surgery. Journal- Society of Laparoendoscopic Surgeons, 18(2), 265-272. https://doi.org/10.4293/108680813X13753907291918

Background and Objectives: Combining laparoscopy and enhanced recovery provides benefit to short-term outcomes after colorectal surgery. Advances in training and techniques have allowed surgeons to operate on cases that are technically challenging an... Read More about Operative time and outcome of enhanced recovery after surgery after laparoscopic colorectal surgery.