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International practice patterns of antibiotic therapy and laboratory testing in bronchiolitis (2020)
Journal Article
Zipursky, A., Kuppermann, N., Finkelstein, Y., Zemek, R., Plint, A. C., Babl, F. E., …Schuh, S. (2020). International practice patterns of antibiotic therapy and laboratory testing in bronchiolitis. Pediatrics, 146(2), https://doi.org/10.1542/peds.2019-3684

BACKGROUND AND OBJECTIVES: International patterns of antibiotic use and laboratory testing in bronchiolitis in emergency departments are unknown. Our objective is to evaluate variation in the use of antibiotics and nonindicated tests in infants with... Read More about International practice patterns of antibiotic therapy and laboratory testing in bronchiolitis.

Loop-mediated isothermal amplification for the early diagnosis of invasive meningococcal disease in children (2020)
Journal Article
Waterfield, T., Lyttle, M. D., McKenna, J., Maney, J., Roland, D., Corr, M., …Fairley, D. (in press). Loop-mediated isothermal amplification for the early diagnosis of invasive meningococcal disease in children. Archives of Disease in Childhood, https://doi.org/10.1136/archdischild-2020-319139

Background Rapid molecular diagnostic testing has the potential to improve the early recognition of meningococcal disease (MD). The aim of this study was to report on the diagnostic test accuracy of point-of-care loop-mediated isothermal amplificatio... Read More about Loop-mediated isothermal amplification for the early diagnosis of invasive meningococcal disease in children.

Exposure and confidence with critical non-airway procedures: A global survey of paediatric emergency medicine physicians (2020)
Journal Article
Craig, S., Auerbach, M., Cheek, J. A., Babl, F., Oakley, E., Nguyen, L., …Dalziel, S. (in press). Exposure and confidence with critical non-airway procedures: A global survey of paediatric emergency medicine physicians. Pediatric Emergency Care, https://doi.org/10.1097/PEC.0000000000002092

Background: Children rarely experience critical illness, resulting in low exposure of emergency physicians (EPs) to critical procedures. Our primary objective was to describe senior EP confidence, most recent performance and/or supervision of criti... Read More about Exposure and confidence with critical non-airway procedures: A global survey of paediatric emergency medicine physicians.

The effect of patient observation on cranial computed tomography rates in children with minor head trauma (2020)
Journal Article
Singh, S., Hearps, S. J., Borland, M. L., Dalziel, S. R., Neutze, J., Donath, S., …Babl, F. E. (in press). The effect of patient observation on cranial computed tomography rates in children with minor head trauma. Academic Emergency Medicine, https://doi.org/10.1111/acem.13942

Background Management of children with minor blunt head trauma often includes a period of observation to determine the need for cranial computed tomography (CT). Our objective was to estimate the effect of planned observation on CT use for each Pedi... Read More about The effect of patient observation on cranial computed tomography rates in children with minor head trauma.

Acute severe paediatric asthma: Study protocol for the development of a core outcome set, a Pediatric Emergency Research Networks (PERN) study (2020)
Journal Article
Craig, S., Babl, F. E., Dalziel, S. R., Gray, C., Powell, C., Al Ansari, K., …Graudins, A. (2020). Acute severe paediatric asthma: Study protocol for the development of a core outcome set, a Pediatric Emergency Research Networks (PERN) study. Trials, 21, https://doi.org/10.1186/s13063-019-3785-6

Background Acute severe childhood asthma is an infrequent, but potentially life-threatening emergency condition. There is a wide range of different approaches to this condition, with very little supporting evidence, leading to significant variation... Read More about Acute severe paediatric asthma: Study protocol for the development of a core outcome set, a Pediatric Emergency Research Networks (PERN) study.

Neonatal head injuries: A prospective Paediatric Research in Emergency Departments International Collaborative cohort study (2019)
Journal Article
Eapen, N., Borland, M. L., Phillips, N., Kochar, A., Dalton, S., Cheek, J. A., …Babl, F. E. (2020). Neonatal head injuries: A prospective Paediatric Research in Emergency Departments International Collaborative cohort study. Journal of Paediatrics and Child Health, 56(5), 764-769. https://doi.org/10.1111/jpc.14736

Aim To characterise the causes, clinical characteristics and short‐term outcomes of neonates who presented to paediatric emergency departments with a head injury. Methods Secondary analysis of a prospective data set of paediatric head injuries a... Read More about Neonatal head injuries: A prospective Paediatric Research in Emergency Departments International Collaborative cohort study.

Research without prior consent in paediatric emergency and critical care medicine (2019)
Journal Article
Picton, A., Woolfall, K., Lyttle, M. D., & Hartshorn, S. (2020). Research without prior consent in paediatric emergency and critical care medicine. Paediatrics and Child Health, 30(2), 74-78. https://doi.org/10.1016/j.paed.2019.11.008

Children and young peoples' healthcare should be evidence-based yet many treatments are unlicensed or prescribed off-label. Research is needed, but prospective informed consent for many emergency and critical care trials is neither feasible nor ethic... Read More about Research without prior consent in paediatric emergency and critical care medicine.

Epidemiology of adolescent trauma in England: A review of TARN data 2008-2017 (2019)
Journal Article
Roberts, Z., Collins, J. A., James, D., Bouamra, O., Young, M., Lyttle, M. D., …Mullen, S. (2019). Epidemiology of adolescent trauma in England: A review of TARN data 2008-2017. Emergency Medicine Journal, 37(1), 25-30. https://doi.org/10.1136/emermed-2018-208329

Objectives Trauma contributes significantly to adolescent morbidity and mortality. We aimed to ascertain the epidemiology of adolescent trauma to inform prevention strategies. Methods Data were abstracted from TARN (Trauma Audit Research Network... Read More about Epidemiology of adolescent trauma in England: A review of TARN data 2008-2017.

Performance of two head injury decision rules evaluated on an external cohort of 18,913 children (2019)
Journal Article
Shavit, I., Rimon, A., Waisman, Y., Borland, M. L., Phillips, N., Kochar, A., …Babl, F. E. (2020). Performance of two head injury decision rules evaluated on an external cohort of 18,913 children. Journal of Surgical Research, 245, 426-433. https://doi.org/10.1016/j.jss.2019.07.090

The Pediatric Emergency Care Applied Research Network (PECARN) decision rule demonstrates high sensitivity for identifying children at low risk for clinically important traumatic brain injury (ciTBI). As with the PECARN rule, the Israeli Decision Alg... Read More about Performance of two head injury decision rules evaluated on an external cohort of 18,913 children.

Clinically important sport‐related traumatic brain injuries in children (2019)
Journal Article
Eapen, N., Davis, G. A., Borland, M. L., Phillips, N., Oakley, E., Hearps, S., …Babl, F. E. (2019). Clinically important sport‐related traumatic brain injuries in children. The Medical journal of Australia, 211(8), 365-366. https://doi.org/10.5694/mja2.50311

Sports participation by children and adolescents is generally high in Australia and New Zealand,1, 2 and many children sustain head injuries of varying severity during such activities. Concussion has received increasing attention, but less is known a... Read More about Clinically important sport‐related traumatic brain injuries in children.

Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial (2019)
Journal Article
Hartshorn, S., Barrett, M. J., Lyttle, M. D., Yee, S. A., & Irvine, A. T. (2019). Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial. Trials, 20, https://doi.org/10.1186/s13063-019-3511-4

Background Pain from injuries is one of the commonest symptoms in children attending emergency departments (EDs), and this is often inadequately treated in both the pre-hospital and ED settings, in part due to challenges of continual assessment and... Read More about Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial.

Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland (2019)
Journal Article
Jahn, H. K., Jahn, I. H., Roland, D., Lyttle, M. D., & Behringer, W. (2019). Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland. Archives of Disease in Childhood, 104(12), 1203-1207. https://doi.org/10.1136/archdischild-2019-316872

Introduction Mobile devices and medical apps are used by healthcare professionals in adult and paediatric emergency departments worldwide. Recently, there has been a drive toward increased digitalisation especially in the UK. This point prevalence su... Read More about Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland.

Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC) (2019)
Journal Article
Waterfield, T., Lyttle, M. D., Shields, M., Fairley, D., Roland, D., McKenna, J., & Woolfall, K. (2019). Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC). Archives of Disease in Childhood, 104(10), 979-983. https://doi.org/10.1136/archdischild-2019-317117

Objective: The Petechiae in Children (PiC) study assesses the utility of presenting features and rapid diagnostic tests in the diagnosis of serious bacterial infection in feverish children with non-blanching rashes. An embedded qualitative study expl... Read More about Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC).

Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis (2019)
Journal Article
Jamal, A., Finkelstein, Y., Kuppermann, N., Freedman, S. B., Florin, T. A., Babl, F. E., …Schuh, S. (2019). Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis. Lancet Child and Adolescent Health, 3(8), 539-547. https://doi.org/10.1016/s2352-4642%2819%2930193-2

Background Clinical guidelines advise against pharmacotherapy in bronchiolitis. However, little is known about global variation in prescribing practices for bronchiolitis at discharge from emergency departments. We aimed to evaluate global variation... Read More about Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis.

Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis (2019)
Journal Article
Woolfall, K., O'Hara, C., Deja, E., Canter, R., Khan, I., Mouncey, P., …Inwald, D. (2019). Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis. Archives of Disease in Childhood, 104(11), 1077-1082. https://doi.org/10.1136/archdischild-2019-316807

Objective: To identify parents' prioritised outcomes by combining qualitative findings from two trial feasibility studies of interventions for paediatric suspected severe infection. Design: Qualitative synthesis combining parent interview data from t... Read More about Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis.

Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT) (2019)
Journal Article
Lyttle, M. D., Bielicki, J. A., Barratt, S., Dunn, D., Finn, A., Harper, L., …Sharland, M. (2019). Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT). BMJ Open, 9(5), e029875. https://doi.org/10.1136/bmjopen-2019-029875

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Introduction Community-acquired pneumonia (CAP) is a common indication for antibiotic treatment in young children. Data are limited regarding the ideal dose and... Read More about Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT).

Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study (2019)
Journal Article
Woolfall, K., Roper, L., Humphreys, A., Lyttle, M. D., Messahel, S., Lee, E., …Appleton, R. (2019). Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study. Trials, 20, https://doi.org/10.1186/s13063-019-3273-z

Background: EcLiPSE (Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children) is a randomised controlled trial (RCT) in the United Kingdom. Challenges to success include the need to immediately administer an intervention... Read More about Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study.

Traumatic brain injury in young children with isolated scalp haematoma (2019)
Journal Article
Bressan, S., Kochar, A., Oakley, E., Borland, M., Phillips, N., Dalton, S., …Babl, F. E. (2019). Traumatic brain injury in young children with isolated scalp haematoma. Archives of Disease in Childhood, 104(7), 664-669. https://doi.org/10.1136/archdischild-2018-316066

Objective Despite high-quality paediatric head trauma clinical prediction rules, the management of otherwise asymptomatic young children with scalp haematomas (SH) can be difficult. We determined the risk of intracranial injury when SH is the only pr... Read More about Traumatic brain injury in young children with isolated scalp haematoma.

Incidence of medically attended paediatric burns across the UK (2019)
Journal Article
Davies, K., Johnson, E. L., Hollén, L., Jones, H. M., Lyttle, M. D., Maguire, S., & Kemp, A. M. (2020). Incidence of medically attended paediatric burns across the UK. Injury Prevention, 26(1), 24-30. https://doi.org/10.1136/injuryprev-2018-042881

Objective: Childhood burns represent a burden on health services, yet the full extent of the problem is difficult to quantify. We estimated the annual UK incidence from primary care (PC), emergency attendances (EA), hospital admissions (HA) and death... Read More about Incidence of medically attended paediatric burns across the UK.

Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis (2019)
Journal Article
Simone, L., Lyttle, M. D., Roland, D., Stephens, D., & Schuh, S. (2019). Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis. Emergency Medicine Journal, 36(3), 148-153. https://doi.org/10.1136/emermed-2018-208000

Background Serious bacterial infections in young infants with bronchiolitis are rare. Febrile infants