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Validating clinical practice guidelines for the management of children with non-blanching rashes in the UK (PiC): A prospective, multicentre cohort study (2020)
Journal Article
McKenna, J. P., McFetridge, L., Maney, J., Patenall, B., Woolfall, K., Lynn, F., …Shields, M. (in press). Validating clinical practice guidelines for the management of children with non-blanching rashes in the UK (PiC): A prospective, multicentre cohort study. Lancet Infectious Diseases, https://doi.org/10.1016/S1473-3099%2820%2930474-6

Background: No previous studies have validated current clinical practice guidelines for the management of non-blanching rashes in children who have received meningococcal B and C vaccinations. The aim of this study was to evaluate the performance o... Read More about Validating clinical practice guidelines for the management of children with non-blanching rashes in the UK (PiC): A prospective, multicentre cohort study.

Need for recovery amongst emergency physicians in the UK and Ireland: A cross-sectional survey (2020)
Journal Article
Cottey, L., Roberts, T., Graham, B., Horner, D., Stevens, K. N., Enki, D., …Latour, J. (2020). Need for recovery amongst emergency physicians in the UK and Ireland: A cross-sectional survey. BMJ Open, 10(11), e041485. https://doi.org/10.1136/bmjopen-2020-041485

OBJECTIVES: To determine the need for recovery (NFR) among emergency physicians and to identify demographic and occupational characteristics associated with higher NFR scores. DESIGN: Cross-sectional electronic survey. SETTING: Emergency departments... Read More about Need for recovery amongst emergency physicians in the UK and Ireland: A cross-sectional survey.

National survey of feasibility of NIV trials for management of children with bronchiolitis (2020)
Journal Article
Rosala-Hallas, A., Jones, A. P., Bedson, E., Compton, V., Fernandes, R. M., Lacy, D., …McNamara, P. S. (2020). National survey of feasibility of NIV trials for management of children with bronchiolitis. BMJ Paediatrics Open, 4(1), e000780. https://doi.org/10.1136/bmjpo-2020-000780

Background Bronchiolitis is a major cause of admission to hospital in children. Non-invasive ventilation (NIV) support with continuous positive airway pressure (CPAP) or high-flow nasal cannula (HFNC) oxygen is routinely used for infants in the UK wi... Read More about National survey of feasibility of NIV trials for management of children with bronchiolitis.

Fifteen minute consultation: When can I use a medical app? (2020)
Journal Article
Rowe-Setz, G., Behringer, W., Roland, D., Lyttle, M. D., & Jahn, H. K. (in press). Fifteen minute consultation: When can I use a medical app?. Archives of Disease in Childhood.education and Practice Edition, edpract-2020-319448. https://doi.org/10.1136/archdischild-2020-319448

Advances in mobile device technology and internet connectivity have created powerful new mobile health (mHealth) and telemedicine capabilities. The guidelines regarding mHealth use in the clinical environment can be conflicting, which has resulted in... Read More about Fifteen minute consultation: When can I use a medical app?.

Emergency care provided to refugee children in Europe: RefuNET: A cross-sectional survey study (2020)
Journal Article
Nijman, R. G., Krone, J., Mintegi, S., Bidlingmaier, C., Maconochie, I. K., Lyttle, M. D., & von Both, U. (2021). Emergency care provided to refugee children in Europe: RefuNET: A cross-sectional survey study. Emergency Medicine Journal, 38(1), 5-13. https://doi.org/10.1136/emermed-2019-208699

Background Refugee children and young people have complex healthcare needs. However, issues related to acute healthcare provision for refugee children across Europe remain unexplored. This study aimed to describe the urgent and emergency healthcare n... Read More about Emergency care provided to refugee children in Europe: RefuNET: A cross-sectional survey study.

Prescribing in a paediatric emergency: A PERUKI survey of prescribing and resuscitation aids (2020)
Journal Article
Jahn, H. K., Jahn, I. H. J., Roland, D., Behringer, W., Lyttle, M., & Paediatric Emergency Research in the United Kingdom, Ireland (PERUKI), . (2021). Prescribing in a paediatric emergency: A PERUKI survey of prescribing and resuscitation aids. Acta Paediatrica, 110(3), 1038-1045. https://doi.org/10.1111/apa.15551

Aim: The aim was to investigate the use of paper-based and electronic prescribing and resuscitation aids in paediatric emergency care from a departmental and individual physician perspective. Methods: A two-stage web-based self-report questionnaire w... Read More about Prescribing in a paediatric emergency: A PERUKI survey of prescribing and resuscitation aids.

Seven-step framework to enhance practitioner explanations and parental understandings of research without prior consent in paediatric emergency and critical care trials (2020)
Journal Article
Roper, L., Lyttle, M. D., Gamble, C., Humphreys, A., Messahel, S., Lee, E. D., …Woolfall, K. (in press). Seven-step framework to enhance practitioner explanations and parental understandings of research without prior consent in paediatric emergency and critical care trials. Emergency Medicine Journal, https://doi.org/10.1136/emermed-2020-209488

Background: Alternatives to prospective informed consent enable the conduct of paediatric emergency and critical care trials. Research without prior consent (RWPC) involves practitioners approaching parents after an intervention has been given and se... Read More about Seven-step framework to enhance practitioner explanations and parental understandings of research without prior consent in paediatric emergency and critical care trials.

Risk of traumatic intracranial haemorrhage in children with bleeding disorders (2020)
Journal Article
Bressan, S., Monagle, P., Dalziel, S. R., Borland, M. L., Phillips, N., Kochar, A., …Paediatric Research in Emergency Departments International Collaborative (PREDICT), . (2020). Risk of traumatic intracranial haemorrhage in children with bleeding disorders. Journal of Paediatrics and Child Health, 56(12), 1891-1897. https://doi.org/10.1111/jpc.15073

Objective: To assess computerized tomography (CT) use and the risk of intracranial haemorrhage (ICH) in children with bleeding disorders following a head trauma Design: Multicentre prospective observational study Setting: 10 paediatric emergency de... Read More about Risk of traumatic intracranial haemorrhage in children with bleeding disorders.

COVID-19 emergency response assessment study: a prospective longitudinal survey of frontline doctors in the UK and Ireland: study protocol (2020)
Journal Article
Roberts, T., Daniels, J., Hulme, W., Horner, D., Lyttle, M. D., Samuel, K., …Carlton, E. (2020). COVID-19 emergency response assessment study: a prospective longitudinal survey of frontline doctors in the UK and Ireland: study protocol. BMJ Open, 10(8), https://doi.org/10.1136/bmjopen-2020-039851

INTRODUCTION: The COVID-19 pandemic is putting an unprecedented strain on healthcare systems globally. The psychological impact on frontline doctors of dealing with the COVID-19 pandemic is currently unknown. This longitudinal professional survey aim... Read More about COVID-19 emergency response assessment study: a prospective longitudinal survey of frontline doctors in the UK and Ireland: study protocol.

International practice patterns of antibiotic therapy and laboratory testing in bronchiolitis (2020)
Journal Article
Zipursky, A., Kuppermann, N., Finkelstein, Y., Zemek, R., Plint, A. C., Babl, F. E., …Schuh, S. (2020). International practice patterns of antibiotic therapy and laboratory testing in bronchiolitis. Pediatrics, 146(2), https://doi.org/10.1542/peds.2019-3684

BACKGROUND AND OBJECTIVES: International patterns of antibiotic use and laboratory testing in bronchiolitis in emergency departments are unknown. Our objective is to evaluate variation in the use of antibiotics and nonindicated tests in infants with... Read More about International practice patterns of antibiotic therapy and laboratory testing in bronchiolitis.

Loop-mediated isothermal amplification for the early diagnosis of invasive meningococcal disease in children (2020)
Journal Article
Waterfield, T., Lyttle, M. D., McKenna, J., Maney, J. A., Roland, D., Corr, M., …Fairley, D. (2020). Loop-mediated isothermal amplification for the early diagnosis of invasive meningococcal disease in children. Archives of Disease in Childhood, 105(12), 1151-1156. https://doi.org/10.1136/archdischild-2020-319139

Background Rapid molecular diagnostic testing has the potential to improve the early recognition of meningococcal disease (MD). The aim of this study was to report on the diagnostic test accuracy of point-of-care loop-mediated isothermal amplificatio... Read More about Loop-mediated isothermal amplification for the early diagnosis of invasive meningococcal disease in children.

Exposure and confidence with critical non-airway procedures: A global survey of paediatric emergency medicine physicians (2020)
Journal Article
Craig, S., Auerbach, M., Cheek, J. A., Babl, F., Oakley, E., Nguyen, L., …Dalziel, S. (in press). Exposure and confidence with critical non-airway procedures: A global survey of paediatric emergency medicine physicians. Pediatric Emergency Care, https://doi.org/10.1097/PEC.0000000000002092

Background: Children rarely experience critical illness, resulting in low exposure of emergency physicians (EPs) to critical procedures. Our primary objective was to describe senior EP confidence, most recent performance and/or supervision of criti... Read More about Exposure and confidence with critical non-airway procedures: A global survey of paediatric emergency medicine physicians.

The effect of patient observation on cranial computed tomography rates in children with minor head trauma (2020)
Journal Article
Singh, S., Hearps, S. J., Borland, M. L., Dalziel, S. R., Neutze, J., Donath, S., …Babl, F. E. (2020). The effect of patient observation on cranial computed tomography rates in children with minor head trauma. Academic Emergency Medicine, 27(9), 832-843. https://doi.org/10.1111/acem.13942

Background Management of children with minor blunt head trauma often includes a period of observation to determine the need for cranial computed tomography (CT). Our objective was to estimate the effect of planned observation on CT use for each Pedi... Read More about The effect of patient observation on cranial computed tomography rates in children with minor head trauma.

Acute severe paediatric asthma: Study protocol for the development of a core outcome set, a Pediatric Emergency Research Networks (PERN) study (2020)
Journal Article
Craig, S., Babl, F. E., Dalziel, S. R., Gray, C., Powell, C., Al Ansari, K., …Graudins, A. (2020). Acute severe paediatric asthma: Study protocol for the development of a core outcome set, a Pediatric Emergency Research Networks (PERN) study. Trials, 21, https://doi.org/10.1186/s13063-019-3785-6

Background Acute severe childhood asthma is an infrequent, but potentially life-threatening emergency condition. There is a wide range of different approaches to this condition, with very little supporting evidence, leading to significant variation... Read More about Acute severe paediatric asthma: Study protocol for the development of a core outcome set, a Pediatric Emergency Research Networks (PERN) study.

Neonatal head injuries: A prospective Paediatric Research in Emergency Departments International Collaborative cohort study (2019)
Journal Article
Eapen, N., Borland, M. L., Phillips, N., Kochar, A., Dalton, S., Cheek, J. A., …Babl, F. E. (2020). Neonatal head injuries: A prospective Paediatric Research in Emergency Departments International Collaborative cohort study. Journal of Paediatrics and Child Health, 56(5), 764-769. https://doi.org/10.1111/jpc.14736

Aim To characterise the causes, clinical characteristics and short‐term outcomes of neonates who presented to paediatric emergency departments with a head injury. Methods Secondary analysis of a prospective data set of paediatric head injuries a... Read More about Neonatal head injuries: A prospective Paediatric Research in Emergency Departments International Collaborative cohort study.

Research without prior consent in paediatric emergency and critical care medicine (2019)
Journal Article
Picton, A., Woolfall, K., Lyttle, M. D., & Hartshorn, S. (2020). Research without prior consent in paediatric emergency and critical care medicine. Paediatrics and Child Health, 30(2), 74-78. https://doi.org/10.1016/j.paed.2019.11.008

Children and young peoples' healthcare should be evidence-based yet many treatments are unlicensed or prescribed off-label. Research is needed, but prospective informed consent for many emergency and critical care trials is neither feasible nor ethic... Read More about Research without prior consent in paediatric emergency and critical care medicine.

Epidemiology of adolescent trauma in England: A review of TARN data 2008-2017 (2019)
Journal Article
Roberts, Z., Collins, J. A., James, D., Bouamra, O., Young, M., Lyttle, M. D., …Mullen, S. (2019). Epidemiology of adolescent trauma in England: A review of TARN data 2008-2017. Emergency Medicine Journal, 37(1), 25-30. https://doi.org/10.1136/emermed-2018-208329

Objectives Trauma contributes significantly to adolescent morbidity and mortality. We aimed to ascertain the epidemiology of adolescent trauma to inform prevention strategies. Methods Data were abstracted from TARN (Trauma Audit Research Network... Read More about Epidemiology of adolescent trauma in England: A review of TARN data 2008-2017.

Performance of two head injury decision rules evaluated on an external cohort of 18,913 children (2019)
Journal Article
Shavit, I., Rimon, A., Waisman, Y., Borland, M. L., Phillips, N., Kochar, A., …Babl, F. E. (2020). Performance of two head injury decision rules evaluated on an external cohort of 18,913 children. Journal of Surgical Research, 245, 426-433. https://doi.org/10.1016/j.jss.2019.07.090

The Pediatric Emergency Care Applied Research Network (PECARN) decision rule demonstrates high sensitivity for identifying children at low risk for clinically important traumatic brain injury (ciTBI). As with the PECARN rule, the Israeli Decision Alg... Read More about Performance of two head injury decision rules evaluated on an external cohort of 18,913 children.

Clinically important sport‐related traumatic brain injuries in children (2019)
Journal Article
Eapen, N., Davis, G. A., Borland, M. L., Phillips, N., Oakley, E., Hearps, S., …Babl, F. E. (2019). Clinically important sport‐related traumatic brain injuries in children. The Medical journal of Australia, 211(8), 365-366. https://doi.org/10.5694/mja2.50311

Sports participation by children and adolescents is generally high in Australia and New Zealand,1, 2 and many children sustain head injuries of varying severity during such activities. Concussion has received increasing attention, but less is known a... Read More about Clinically important sport‐related traumatic brain injuries in children.

Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial (2019)
Journal Article
Hartshorn, S., Barrett, M. J., Lyttle, M. D., Yee, S. A., & Irvine, A. T. (2019). Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial. Trials, 20, https://doi.org/10.1186/s13063-019-3511-4

Background Pain from injuries is one of the commonest symptoms in children attending emergency departments (EDs), and this is often inadequately treated in both the pre-hospital and ED settings, in part due to challenges of continual assessment and... Read More about Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial.