Modelling of the activation of G-protein coupled receptors: Drug free constitutive receptor activity
(2010)
Journal Article
Woodroffe, P. J., Bridge, L., King, J. R., Chen, C. Y., & Hill, S. J. (2010). Modelling of the activation of G-protein coupled receptors: Drug free constitutive receptor activity. Journal of Mathematical Biology, 60(3), 313-346. https://doi.org/10.1007/s00285-009-0268-5
G-protein coupled receptors (GPCRs) form a crucial component of approximately 80% of hormone pathways. In this paper, the most popular mechanism for activation of GPCRs-the shuttling mechanism-is modelled mathematically. An asymptotic analysis of thi... Read More about Modelling of the activation of G-protein coupled receptors: Drug free constitutive receptor activity.