P. J. Woodroffe
Modelling of the activation of G-protein coupled receptors: Drug free constitutive receptor activity
Woodroffe, P. J.; Bridge, Lloyd; King, J. R.; Chen, C. Y.; Hill, S. J.
Authors
Abstract
G-protein coupled receptors (GPCRs) form a crucial component of approximately 80% of hormone pathways. In this paper, the most popular mechanism for activation of GPCRs-the shuttling mechanism-is modelled mathematically. An asymptotic analysis of this model clarifies the dynamics of the system in the absence of drug, in particular which reactions dominate during the different timescales. Equilibrium analysis of the model demonstrates the model's ability to predict constitutive receptor activity. © Springer-Verlag 2009.
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Mar 13, 2009 |
| Publication Date | Sep 1, 2010 |
| Journal | Journal of Mathematical Biology |
| Print ISSN | 0303-6812 |
| Electronic ISSN | 1432-1416 |
| Publisher | Springer (part of Springer Nature) |
| Peer Reviewed | Peer Reviewed |
| Volume | 60 |
| Issue | 3 |
| Pages | 313-346 |
| DOI | https://doi.org/10.1007/s00285-009-0268-5 |
| Keywords | g-protein coupled receptors, mathematical modelling, asymptotic analysis |
| Public URL | https://uwe-repository.worktribe.com/output/989412 |
| Publisher URL | http://dx.doi.org/10.1007/s00285-009-0268-5 |