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Modelling of the activation of G-protein coupled receptors: Drug free constitutive receptor activity

Woodroffe, P. J.; Bridge, Lloyd; King, J. R.; Chen, C. Y.; Hill, S. J.

Authors

P. J. Woodroffe

Lloyd Bridge Lloyd.Bridge@uwe.ac.uk
Senior Lecturer in Mathematics

J. R. King

C. Y. Chen

S. J. Hill



Abstract

G-protein coupled receptors (GPCRs) form a crucial component of approximately 80% of hormone pathways. In this paper, the most popular mechanism for activation of GPCRs-the shuttling mechanism-is modelled mathematically. An asymptotic analysis of this model clarifies the dynamics of the system in the absence of drug, in particular which reactions dominate during the different timescales. Equilibrium analysis of the model demonstrates the model's ability to predict constitutive receptor activity. © Springer-Verlag 2009.

Citation

Woodroffe, P. J., Bridge, L., King, J. R., Chen, C. Y., & Hill, S. J. (2010). Modelling of the activation of G-protein coupled receptors: Drug free constitutive receptor activity. Journal of Mathematical Biology, 60(3), 313-346. https://doi.org/10.1007/s00285-009-0268-5

Journal Article Type Article
Acceptance Date Mar 13, 2009
Publication Date Sep 1, 2010
Journal Journal of Mathematical Biology
Print ISSN 0303-6812
Electronic ISSN 1432-1416
Publisher Springer (part of Springer Nature)
Peer Reviewed Peer Reviewed
Volume 60
Issue 3
Pages 313-346
DOI https://doi.org/10.1007/s00285-009-0268-5
Keywords g-protein coupled receptors, mathematical modelling, asymptotic analysis
Public URL https://uwe-repository.worktribe.com/output/989412
Publisher URL http://dx.doi.org/10.1007/s00285-009-0268-5