All Outputs (4)

The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase (2019)
Journal Article
Al-Salihi, S. A. A., Dao, T. T., Williams, K., Bailey, A. M., & Foster, G. D. (2019). The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase. Molecular Biotechnology, 61(10), 754-762. https://doi.org/10.1007/s12033-019-00199-x

Naematolin is a biologically active sesquiterpene produced by Hypholoma species. Low titres and complex structure constrain the exploitation of this secondary metabolite. Here, we de novo sequenced the H. fasciculare genome to identify a candidate bi... Read More about The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase.

Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase (2019)
Journal Article
Yang, X. L., Friedrich, S., Yin, S., Piech, O., Williams, K., Simpson, T. J., & Cox, R. (2019). Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase. Chemical Science, 10(36), 8478-8489. https://doi.org/10.1039/C9SC03173A

Exchange of 32 different sub-fragments of the C-methyltransferase (C-MeT), pseudo-ketoreductase (ΨKR) and ketoreductase (KR) catalytic domains of the tenellin iterative Type I polyketide synthase non ribosomal peptide synthetase (PKS-NRPS) TENS by ho... Read More about Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase.

Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease (2019)
Journal Article
Banks, A. M., Aminuddin, F., Williams, K., Batstone, T., Barker, G. L. A., Foster, G. D., & Bailey, A. M. (2019). Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease. Microbiology Resource Announcements, 8(19), https://doi.org/10.1128/MRA.00340-19

The fungus Lecanicillium fungicola causes dry bubble disease in the white button mushroom Agaricus bisporus. Control strategies are limited, as both the host and pathogen are fungi, and there is limited understanding of the interactions in this patho... Read More about Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease.

Cladobotric acids: Metabolites from cultures of Cladobotryum sp., Semisynthetic analogues and antibacterial activity (2019)
Journal Article
Dao, T. T., Williams, K., De Mattos-Shipley, K. M., Song, Z., Takebayashi, Y., Simpson, T. J., …Willis, C. L. (2022). Cladobotric acids: Metabolites from cultures of Cladobotryum sp., Semisynthetic analogues and antibacterial activity. Journal of Natural Products, 85(3), 572-580. https://doi.org/10.1021/acs.jnatprod.1c01063

Three new polyketide-derived natural products, cladobotric acids G-I (1-3), and six known metabolites (4, 5, 8-11) were isolated from fermentation of the fungus Cladobotryum sp. grown on rice. Their structures were elucidated by extensive spectroscop... Read More about Cladobotric acids: Metabolites from cultures of Cladobotryum sp., Semisynthetic analogues and antibacterial activity.