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Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals (2017)
Journal Article
Law, F. D., Diaper, A. M., Melichar, J. K., Coulton, S., Nutt, D. J., & Myles, J. S. (2017). Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals. Journal of Psychopharmacology, 31(8), 1046-1055. https://doi.org/10.1177/0269881117711710

© British Association for Psychopharmacology. Buprenorphine/naloxone, methadone and lofexidine are medications with utility in the treatment of opiate withdrawal. We report the first randomised controlled trial to compare the effects of these two med... Read More about Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals.

A randomised trial of the effect of the glycine reuptake inhibitor Org 25935 on cognitive performance in healthy male volunteers (2014)
Journal Article
Christmas, D., Diaper, A., Wilson, S., Rich, A., Phillips, S., Udo de Haes, J., …Nutt, D. (2014). A randomised trial of the effect of the glycine reuptake inhibitor Org 25935 on cognitive performance in healthy male volunteers. Human Psychopharmacology: Clinical and Experimental, 29(2), 163-171. https://doi.org/10.1002/hup.2384

Objective Cognitive impairment is integral to many neurological illnesses. Specific enhancement of glutamatergic transmission may improve memory and learning. Org 25935 increases the synaptic availability of glycine, an obligate co-agonist with gluta... Read More about A randomised trial of the effect of the glycine reuptake inhibitor Org 25935 on cognitive performance in healthy male volunteers.

Effects of 7.5% CO2-induced anxiety on individual performance: During a group computer combat game (2013)
Journal Article
Diaper, A., Nutt, D. J., Munafò, M. R., White, J. L., Farmer, E. W., & Bailey, J. E. (2013). Effects of 7.5% CO2-induced anxiety on individual performance: During a group computer combat game. Military Psychology, 25(6), 615-622. https://doi.org/10.1037/mil0000017

The inhalation of 7.5% CO2 has been shown to induce cognitive effects similar to anxiety. Sixteen healthy participants (14 male mean age 25.6 years) inhaled either a mixture of 7.5% CO2 gas or air while playing a group combat computer game. Participa... Read More about Effects of 7.5% CO2-induced anxiety on individual performance: During a group computer combat game.

Pharmacological strategies for detoxification (2013)
Journal Article
Diaper, A. M., Law, F. D., & Melichar, J. K. (2014). Pharmacological strategies for detoxification. British Journal of Clinical Pharmacology, 77(2), 302-314. https://doi.org/10.1111/bcp.12245

Detoxification refers to the safe discontinuation from a substance of dependence and is distinct from relapse prevention. Detoxification usually takes between a few days and a few weeks to complete, depending on the substance being misused, the sever... Read More about Pharmacological strategies for detoxification.

Changes in cardiovascular function after venlafaxine but not pregabalin in healthy volunteers: A double-blind, placebo-controlled study of orthostatic challenge, blood pressure and heart rate (2013)
Journal Article
Diaper, A., Rich, A. S., Wilson, S. J., Craig, K., Dourish, C. T., Dawson, G. R., …Bailey, J. E. (2013). Changes in cardiovascular function after venlafaxine but not pregabalin in healthy volunteers: A double-blind, placebo-controlled study of orthostatic challenge, blood pressure and heart rate. Human Psychopharmacology: Clinical and Experimental, 28(6), 562-575. https://doi.org/10.1002/hup.2346

It is generally thought that venlafaxine raises blood pressure at higher doses; however, some studies have found no effect or a decrease in blood pressure. The aim of this study was to evaluate the cardiovascular (CV) effects of 3 weeks of dosing wit... Read More about Changes in cardiovascular function after venlafaxine but not pregabalin in healthy volunteers: A double-blind, placebo-controlled study of orthostatic challenge, blood pressure and heart rate.

The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO2-induced anxiety (2012)
Journal Article
Diaper, A., Papadopoulos, A., Rich, A. S., Dawson, G. R., Dourish, C. T., Nutt, D. J., & Bailey, J. E. (2012). The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO2-induced anxiety. Human Psychopharmacology: Clinical and Experimental, 27(6), 540-548. https://doi.org/10.1002/hup.2261

Symptoms of anxiety induced by 7.5% CO2 inhalation can be attenuated by acute administration of GABAA receptor anxiolytics such as lorazepam and alprazolam. This study investigated if these effects are dose-related, by comparing a 0.5 mg dose (consid... Read More about The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO2-induced anxiety.

Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic (2012)
Journal Article
Diaper, A., Osman-Hicks, V., Rich, A. S., Craig, K., Dourish, C. T., Dawson, G. R., …Bailey, J. E. (2013). Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic. Journal of Psychopharmacology, 27(2), 135-145. https://doi.org/10.1177/0269881112443742

Previous studies have shown that subjective and objective symptoms of anxiety induced by 7.5% CO2 inhalation can be attenuated by anxiolytics such as lorazepam and, to a lesser extent, paroxetine. Venlafaxine and pregabalin, two other licensed treatm... Read More about Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic.

The effects of 7.5% carbon dioxide inhalation on task performance in healthy volunteers (2011)
Journal Article
Diaper, A., Nutt, D. J., Munafò, M. R., White, J. L., Farmer, E. W., & Bailey, J. E. (2012). The effects of 7.5% carbon dioxide inhalation on task performance in healthy volunteers. Journal of Psychopharmacology, 26(4), 487-496. https://doi.org/10.1177/0269881111415729

Studies have shown that anxiety can positively or negatively affect performance with respect to focusing of attention or distractibility, subjective workload and effort (Humphreys and Revelle, 1984). The inhalation of carbon dioxide (CO2) is associat... Read More about The effects of 7.5% carbon dioxide inhalation on task performance in healthy volunteers.

Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety (2011)
Journal Article
Bailey, J. E., Papadopoulos, A., Diaper, A., Phillips, S., Schmidt, M. E., Van Der Ark, P., …Nutt, D. J. (2011). Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety. Journal of Psychopharmacology, 25(9), 1199-1206. https://doi.org/10.1177/0269881111400650

We have validated the use of prolonged inhalation of 7.5% carbon dioxide (CO2) as a human model of anxiety and have shown that drugs from two prototypical classes of anxiolytics, benzodiazepines and a serotonin reuptake inhibitor, attenuate CO2-induc... Read More about Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety.

Effects of 7.5% CO2 inhalation on allocation of spatial attention to facial cues of emotional expression (2011)
Journal Article
Cooper, R. M., Bailey, J. E., Diaper, A., Stirland, R., Renton, L. E., Benton, C. P., …Munafò, M. R. (2011). Effects of 7.5% CO2 inhalation on allocation of spatial attention to facial cues of emotional expression. Cognition and Emotion, 25(4), 626-638. https://doi.org/10.1080/02699931.2010.508887

Increased vigilance to threat-related stimuli is thought to be a core cognitive feature of anxiety. We sought to investigate the cognitive impact of experimentally induced anxiety, by means of a 7.5% CO2 challenge, which acts as an unconditioned anxi... Read More about Effects of 7.5% CO2 inhalation on allocation of spatial attention to facial cues of emotional expression.

A validation of the 7.5% CO2 model of GAD using paroxetine and lorazepam in healthy volunteers (2007)
Journal Article
Bailey, J. E., Kendrick, A., Diaper, A., Potokar, J. P., & Nutt, D. J. (2007). A validation of the 7.5% CO2 model of GAD using paroxetine and lorazepam in healthy volunteers. Journal of Psychopharmacology, 21(1), 42-49. https://doi.org/10.1177/0269881106063889

The inhalation of 7.5% carbon dioxide (CO2) in healthy subjects produces an increase in blood pressure and heart rate, and increased feelings of anxiety, fear and tension (Bailey et al. 2005). As this state is similar to that of general anxiety rathe... Read More about A validation of the 7.5% CO2 model of GAD using paroxetine and lorazepam in healthy volunteers.

Sleep disturbance and its management in older adults (2005)
Book Chapter
Diaper, A., & Hindmarch, I. (2005). Sleep disturbance and its management in older adults. In R. Bullock, & S. Curran (Eds.), Practical Old Age Psychopharmacology: A Multi-Professional Approach Radcliffe Publishing Ltd

Tailoring mental illness drug treatments specifically for elderly people has been a neglected area. This book brings together findings from recent multi-disciplinary research and the practical aspects of old age psychiatry. By taking into account the... Read More about Sleep disturbance and its management in older adults.

A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults (2004)
Journal Article
Diaper, A., & Hindmarch, I. (2004). A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults. Phytotherapy Research, 18(10), 831-836. https://doi.org/10.1002/ptr.1574

One of the most popular herbal remedies for the alleviation of sleep problems is valerian. However, research into valerian is sparse, and studies differ greatly with respect to design, measures, and preparations used. This clinical study used standar... Read More about A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults.


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