Dr Alison Cobb Alison.Diaper@uwe.ac.uk
Senior Research Fellow - CHCR
Pharmacological strategies for detoxification
Diaper, Alison M.; Law, Fergus D.; Melichar, Jan K.
Authors
Fergus D. Law
Jan K. Melichar
Abstract
Detoxification refers to the safe discontinuation from a substance of dependence and is distinct from relapse prevention. Detoxification usually takes between a few days and a few weeks to complete, depending on the substance being misused, the severity of dependence and the support available to the user. Psychosocial therapies alongside pharmacological treatments are essential to improve outcome. The dependencies considered in this overview are detoxification from opioids (with methadone, buprenorphine, α2-adrenoceptor agonists and adjunct medications), alcohol (with benzodiazepines, anti-glutamatergics and γ-aminobutyric acid (GABA)-ergic drugs), stimulants and cannabis (with no clear recommended pharmacological treatments), benzodiazepines (with dose tapering) and nicotine (with nicotine replacement therapy, antidepressants and partial agonists). Evidence is limited by a lack of controlled trials robust enough for review bodies, and more research is required into optimal treatment doses and regimes, alone and in combination. © 2013 The British Pharmacological Society.
Citation
Diaper, A. M., Law, F. D., & Melichar, J. K. (2014). Pharmacological strategies for detoxification. British Journal of Clinical Pharmacology, 77(2), 302-314. https://doi.org/10.1111/bcp.12245
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 4, 2013 |
Online Publication Date | Oct 4, 2013 |
Publication Date | Feb 1, 2014 |
Deposit Date | Nov 21, 2019 |
Journal | British Journal of Clinical Pharmacology |
Print ISSN | 0306-5251 |
Electronic ISSN | 1365-2125 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 77 |
Issue | 2 |
Pages | 302-314 |
DOI | https://doi.org/10.1111/bcp.12245 |
Public URL | https://uwe-repository.worktribe.com/output/4670079 |
Publisher URL | https://doi.org/10.1111/bcp.12245 |
You might also like
Downloadable Citations
About UWE Bristol Research Repository
Administrator e-mail: repository@uwe.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search