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Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation

Hancock, john; Whiteman, Matthew

Authors

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John Hancock John.Hancock@uwe.ac.uk
Professor in Cell Signalling

Matthew Whiteman



Abstract

Growth and maintenance of cells is partly controlled by the production and perception of a range of small relatively reactive molecules, including reactive oxygen species, nitric oxide and hydrogen sulfide: what may be dubbed reactive signaling molecules (RSM). These compounds are generated by enzymes or arrive from the cell's environment, often produced in response to cellular stress, including temperature, salt or drought. Regularly studied on an individual basis, such compounds are often in cells at the same time and so interactions between them need to be considered. RSM alter antioxidants in cells, possibly leading to oxidative stress and cell death, perhaps through apoptotic pathways. Gene expression can alter, with the suite of genes regulated being similar for the different RSM. In reality the total cellular response will be the sum of interactions and perception of all RSM. RSM will influence the internal cellular redox poise and compete for thiols, the final modifications of which may determine the response. Lastly, other small molecules with potentially signaling roles need to be considered, e.g. hydrogen gas, which too can influence antioxidant levels in cells. Therefore, a holistic approach needs to be taken to understand the overall cellular response to RSM.

Citation

Hancock, J., & Whiteman, M. (2018). Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation. Free Radical Biology and Medicine, 120(S1), s9. https://doi.org/10.1016/j.freeradbiomed.2018.04.040

Journal Article Type Article
Acceptance Date May 14, 2018
Online Publication Date May 14, 2018
Publication Date May 20, 2018
Journal Free Radical Biology and Medicine
Print ISSN 0891-5849
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 120
Issue S1
Pages s9
DOI https://doi.org/10.1016/j.freeradbiomed.2018.04.040
Keywords reactive oxygen species, redox, cell signalling
Public URL https://uwe-repository.worktribe.com/output/867980
Publisher URL http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.040