Retrospective cohort study of admission timing and mortality following COVID-19 infection in England

Alaa, Ahmed; Qian, Zhaozhi; Rashbass, Jem; Benger, Jonathan; van der Schaar, Mihaela

Abstract

Objectives We investigated whether the timing of hospital admission is associated with the risk of mortality for patients with COVID-19 in England, and the factors associated with a longer interval between symptom onset and hospital admission.

Design Retrospective observational cohort study of data collected by the COVID-19 Hospitalisation in England Surveillance System (CHESS). Data were analysed using multivariate regression analysis.

Setting Acute hospital trusts in England that submit data to CHESS routinely.

Participants Of 14 150 patients included in CHESS until 13 May 2020, 401 lacked a confirmed diagnosis of COVID-19 and 7666 lacked a recorded date of symptom onset. This left 6083 individuals, of whom 15 were excluded because the time between symptom onset and hospital admission exceeded 3 months. The study cohort therefore comprised 6068 unique individuals.

Main outcome measures All-cause mortality during the study period.

Results Timing of hospital admission was an independent predictor of mortality following adjustment for age, sex, comorbidities, ethnicity and obesity. Each additional day between symptom onset and hospital admission was associated with a 1% increase in mortality risk (HR 1.01; p

Citation

Alaa, A., Qian, Z., Rashbass, J., Benger, J., & van der Schaar, M. (2020). Retrospective cohort study of admission timing and mortality following COVID-19 infection in England. BMJ Open, 10(11), Article e042712. https://doi.org/10.1136/bmjopen-2020-042712

• Journal Article Type: Article
• Acceptance Date: Nov 23, 2020
• Online Publication Date: Nov 23, 2020
• Publication Date: Nov 23, 2020
• Deposit Date: Nov 2, 2021
• Publicly Available Date: Nov 2, 2021
• Journal: BMJ Open
• Electronic ISSN: 2044-6055
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 11
• Article Number: e042712
• DOI: https://doi.org/10.1136/bmjopen-2020-042712
• Keywords: General Medicine
• Public URL: https://uwe-repository.worktribe.com/output/8044513