Expression of lumican in the synovial fluid of patients with osteoarthritis (OA)

Quasnichka, Helen; Kerr, B. C.; Jones, P.; Morgan, A.; Hughes, C.; Caterson, B.

Abstract

Introduction Fragmentation of small leucine rich proteogly-
cans (SLRPs), including decorin, biglycan, lumican, keratocan
and fibromodulin, has been shown to occur in osteoarthritic
articular cartilage (Melrose et al. 2008). We have previously
shown an increased expression of lumican and keratocan, in
osteoarthritic articular cartilage (Kerr et al. 2006). The long-
term aim of this project is to develop ELISAs for the detection
of SLRP metabolites, and validate these potential biomarkers
with synovial fluid and serum samples from a large cohort of
normal and osteoarthritic patients. Initially, we determined
whether lumican could be detected in synovial fluid of
patients with and without osteoarthritis. We also investigated
the expression of lumican in an in vitro, cultured explant
model of OA.

Citation

Quasnichka, H., Kerr, B. C., Jones, P., Morgan, A., Hughes, C., & Caterson, B. (2011). Expression of lumican in the synovial fluid of patients with osteoarthritis (OA). International Journal of Experimental Pathology, 92(6), A1-A38. https://doi.org/10.1111/j.1365-2613.2011.00780.x

• Journal Article Type: Article
• Online Publication Date: Nov 28, 2011
• Publication Date: Nov 28, 2011
• Deposit Date: Jun 28, 2023
• Journal: International Journal of Experimental Pathology
• Print ISSN: 0959-9673
• Electronic ISSN: 1365-2613
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 92
• Issue: 6
• Pages: A1-A38
• DOI: https://doi.org/10.1111/j.1365-2613.2011.00780.x
• Keywords: Cell Biology; Molecular Biology; Pathology and Forensic Medicine
• Public URL: https://uwe-repository.worktribe.com/output/10339144
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2613.2011.00780.x