Outputs (107)

Investigation of Testosterone, Androstenone, and Estradiol Metabolism in HepG2 Cells and Primary Culture Pig Hepatocytes and Their Effects on 17βHSD7 Gene Expression (2012)
Journal Article
Chen, G., Li, S., Dong, X., Bai, Y., Chen, A., Yang, S., …Doran, O. (2012). Investigation of Testosterone, Androstenone, and Estradiol Metabolism in HepG2 Cells and Primary Culture Pig Hepatocytes and Their Effects on 17βHSD7 Gene Expression. PLoS ONE, 7(12), e52255. https://doi.org/10.1371/journal.pone.0052255

Steroid metabolism is important in various species. The accumulation of androgen metabolite, androstenone, in pig adipose tissue is negatively associated with pork flavor, odour and makes the meat unfit for human consumption. The 17β-hydroxysteroid d... Read More about Investigation of Testosterone, Androstenone, and Estradiol Metabolism in HepG2 Cells and Primary Culture Pig Hepatocytes and Their Effects on 17βHSD7 Gene Expression.

The effect of pressure and mobile phase velocity on the retention properties of small analytes and large biomolecules in ultra-high pressure liquid chromatography (2012)
Journal Article
Fekete, S., Veuthey, J. L., McCalley, D. V., & Guillarme, D. (2012). The effect of pressure and mobile phase velocity on the retention properties of small analytes and large biomolecules in ultra-high pressure liquid chromatography. Journal of Chromatography A, 1270, 127-138. https://doi.org/10.1016/j.chroma.2012.10.056

A possible complication of ultra-high pressure liquid chromatography (UHPLC) is related to the effect of pressure and mobile phase velocity on the retention properties of the analytes. In the present work, numerous model compounds have been selected... Read More about The effect of pressure and mobile phase velocity on the retention properties of small analytes and large biomolecules in ultra-high pressure liquid chromatography.

Investigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17βHSD7 gene expression (2012)
Journal Article
Chen, G., Li, S., Dong, X., Bai, Y., Chen, A., Yang, S., …Doran, O. (2012). Investigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17βHSD7 gene expression. PLoS ONE, 7, e52255. https://doi.org/10.1371/journal.pone.0052255

EACR poster prize winner for "Autolysosomal β-catenin degradation regulates Wnt-autophagy/p62 crosstalk" (2012)
Presentation / Conference
Greenhough, A. (2012, December). EACR poster prize winner for "Autolysosomal β-catenin degradation regulates Wnt-autophagy/p62 crosstalk". Poster presented at 29th Genes & Cancer Conference, University of Warwick, Warwick, England

(EACR Poster Prize) The Wnt/β-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β-catenin signalling pathway as a negative regulator of both ba... Read More about EACR poster prize winner for "Autolysosomal β-catenin degradation regulates Wnt-autophagy/p62 crosstalk".

Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and δ5-, δ6-desaturase protein expression in steer muscles (2012)
Journal Article
Pickova, J., Turner, T. D., Mitchell, A., Duynisveld, J., Pickiva, J., Doran, O., & McNiven, M. A. (2012). Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and δ5-, δ6-desaturase protein expression in steer muscles. animal, 6(12), 1973-1984. https://doi.org/10.1017/S1751731112000985

This study investigated effects of roasted or extruded oilseed supplementation ranging in n-6/n-3 ratios from 0.3 to 5.0 on the fatty acid composition and expression of delta-5 desaturase (δ5d) and δ6-desaturase (δ6d) protein in commercial steer chee... Read More about Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and δ5-, δ6-desaturase protein expression in steer muscles.

Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation (2012)
Journal Article
Hull, J., Hindy, M. E., Kehoe, P. G., Chalmers, K., Love, S., & Conway, M. E. (2012). Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation. Journal of Neurochemistry, 123(6), 997-1009. https://doi.org/10.1111/jnc.12044

The branched chain aminotransferase enzymes (BCAT) serve as nitrogen donors for the production of 30% of de novo glutamate synthesis in rat brain. Despite the importance of this major metabolite and excitatory neurotransmitter, the distribution of BC... Read More about Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation.

Investigating mechanisms for non-linear genotoxic responses, and analysing their effects in binary combination (2012)
Journal Article
Jenkins, G. J. S., Doak, S. H., Thomas, A. D., Verma, J. R., Rees, B. J., Lewis, P. D., …Johnson, G. E. (2012). Investigating mechanisms for non-linear genotoxic responses, and analysing their effects in binary combination. Genes and Environment, 34(4), 179-185. https://doi.org/10.3123/jemsge.34.179

A recent shift by the scientific and regulatory community, towards accepting the existence of non-linear dose responses for certain DNA reactive genotoxic agents, has unveiled a myriad of questions regarding their biological basis. The mechanisms res... Read More about Investigating mechanisms for non-linear genotoxic responses, and analysing their effects in binary combination.

MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway (2012)
Journal Article
Váradi, A., Molnár, E., Hayward, K., Brozzi, F., Lajus, S., Diraison, F., …Varadi, A. (2012). MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway. Molecular Biology of the Cell, 23(22), 4444-4455. https://doi.org/10.1091/mbc.E12-05-0369

Myosin- and Rab-interacting protein (MyRIP), which belongs to the protein kinase A (PKA) - anchoring family, is implicated in hormone secretion. However, its mechanism of action is not fully elucidated. Here we investigate the role of MyRIP in myosin... Read More about MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway.

Open science and public engagement: Exploring the potential of the open paradigm to support public engagement with science (2012)
Thesis
Grand, A. (in press). Open science and public engagement: Exploring the potential of the open paradigm to support public engagement with science. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/941959

Open science, a practice in which the entirety of a research project is made available, via the Internet, using a variety of tools and techniques, is an emerging approach to the conduct of science. The hypothesis that open science therefore has the p... Read More about Open science and public engagement: Exploring the potential of the open paradigm to support public engagement with science.

The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine (2012)
Journal Article
Honeychurch, K. C., & Hart, J. P. (2012). The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine. Advances in Analytical Chemistry, 2(5), 46-52. https://doi.org/10.5923/j.aac.20120205.01

Screen-printed carbon electrodes (SPCEs) incorporating the electrocatalyst cobalt phthalocyanine (CoPC) have been successfully used for the manufacture of microband electrodes for the determination of reduced glutathione (GSH). Initially investigati... Read More about The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine.