Outputs (103)

Cardiopulmonary reserve as determined by cardiopulmonary exercise testing correlates with length of stay and predicts complications after radical cystectomy (2015)
Journal Article
Darweish, A., Tolchard, S., Angell, J., Pyke, M., Lewis, S., Dodds, N., …Gillatt, D. (2015). Cardiopulmonary reserve as determined by cardiopulmonary exercise testing correlates with length of stay and predicts complications after radical cystectomy. BJU International, 115(4), 554-561. https://doi.org/10.1111/bju.12895

© 2014 The Authors. BJU International © 2014 BJU International. ObjectiveTo investigate whether poor preoperative cardiopulmonary reserve and comorbid state dictate high-risk status and can predict complications in patients undergoing radical cystect... Read More about Cardiopulmonary reserve as determined by cardiopulmonary exercise testing correlates with length of stay and predicts complications after radical cystectomy.

The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication (2015)
Journal Article
Lowndes, S. A., White, P., Hooper, C. E., Lyburn, I. D., Searle, J., Darby, M., …Maskell, N. A. (2015). The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication. British Journal of Cancer, 112(7), 1175-1182. https://doi.org/10.1038/bjc.2015.62

© 2015 Cancer Research UK. All rights reserved. Background: Robust markers that predict prognosis and detect early treatment response in malignant pleural mesothelioma (MPM) would enhance patient care. Methods: Consecutive patients with MPM who were... Read More about The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication.

A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: A proof of principle pilot study (2015)
Journal Article
Maskell, N. A., Kahan, B. C., Lyen, S. M., Sequeiros, I., Braybrooke, J. P., Morley, A. J., …Maskell, N. A. (2015). A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: A proof of principle pilot study. PLoS ONE, 10(3), https://doi.org/10.1371/journal.pone.0118569

© 2015 Clive et al. Introduction: Animal studies have shown Zoledronic Acid (ZA) may diminish pleural fluid accumulation and tumour bulk in malignant pleural disease (MPD). We performed a pilot study to evaluate its effects in humans. Methods: We und... Read More about A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: A proof of principle pilot study.

The effect of chemotherapy on health-related quality of life in mesothelioma: Results from the SWAMP trial (2015)
Journal Article
Arnold, D. T., Hooper, C. E., Morley, A., White, P., Lyburn, I. D., Searle, J., …Maskell, N. A. (2015). The effect of chemotherapy on health-related quality of life in mesothelioma: Results from the SWAMP trial. British Journal of Cancer, 112(7), 1183-1189. https://doi.org/10.1038/bjc.2015.77

© 2015 Cancer Research UK. All rights reserved. Background: The effect of chemotherapy on health-related quality of life (HRQoL) in malignant pleural mesothelioma (MPM) is poorly understood. Patient-individualised prognostication and prediction of tr... Read More about The effect of chemotherapy on health-related quality of life in mesothelioma: Results from the SWAMP trial.

Predictive value of abnormally raised serum bilirubin in acute appendicitis: A cohort study (2015)
Journal Article
White, P., Chambers, A. C., Bismohun, S. L., Davies, H., White, P., & Patil, A. V. (2015). Predictive value of abnormally raised serum bilirubin in acute appendicitis: A cohort study. International Journal of Surgery, 13, 207-210. https://doi.org/10.1016/j.ijsu.2014.11.041

© 2014 Surgical Associates Ltd. Appendicitis is a common clinical diagnosis aided by biochemical, haematological and radiological investigations. The role of some investigations, such as bilirubin, is controversial but could indicate complicated appe... Read More about Predictive value of abnormally raised serum bilirubin in acute appendicitis: A cohort study.

EGFR and EGFRvIII analysis in glioblastoma as therapeutic biomarkers (2015)
Journal Article
Kurian, K. M., DeSouza, R. M., Haynes, H. R., Faulkner, C., Palmer, A., Williams, H., …Kurian, K. M. (2015). EGFR and EGFRvIII analysis in glioblastoma as therapeutic biomarkers. British Journal of Neurosurgery, 29(1), 23-29. https://doi.org/10.3109/02688697.2014.950631

Copyright © 2014 The Neurosurgical Foundation. Introduction. EGFR and EGFRvIII analysis is of current interest because of new EGFRvIII vaccine trials opened in the UK. EGFR activation promotes cellular proliferation via activation of MAPK and PI3K-Ak... Read More about EGFR and EGFRvIII analysis in glioblastoma as therapeutic biomarkers.

Pleural irrigation trial (PIT): A randomised controlled trial of pleural irrigation with normal saline versus standard care in patients with pleural infection (2015)
Journal Article
Maskell, N. A., Zahan-Evans, N., Harvey, J. E., Medford, A. R., Clive, A. O., Edey, A. J., …Maskell, N. A. (2015). Pleural irrigation trial (PIT): A randomised controlled trial of pleural irrigation with normal saline versus standard care in patients with pleural infection. European Respiratory Journal, 46(2), 456-463. https://doi.org/10.1183/09031936.00147214

© ERS 2015. Pleural infection is increasing in incidence. Despite optimal medical management, up to 30% of patients will die or require surgery. Case reports suggest that irrigation of the pleural space with saline may be beneficial. A randomised con... Read More about Pleural irrigation trial (PIT): A randomised controlled trial of pleural irrigation with normal saline versus standard care in patients with pleural infection.

BRAF Fusion Analysis in Pilocytic Astrocytomas: KIAA1549-BRAF 15-9 Fusions Are More Frequent in the Midline Than Within the Cerebellum (2015)
Journal Article
Faulkner, C., Ellis, H. P., Shaw, A., Penman, C., Palmer, A., Wragg, C., …Kurian, K. M. (2015). BRAF Fusion Analysis in Pilocytic Astrocytomas: KIAA1549-BRAF 15-9 Fusions Are More Frequent in the Midline Than Within the Cerebellum. Journal of Neuropathology and Experimental Neurology, 74(9), 867-872. https://doi.org/10.1097/NEN.0000000000000226

Copyright © 2015 by the American Association of Neuropathologists, Inc. Pilocytic astrocytomas (PAs) are increasingly tested for KIAA1549-BRAF fusions. We used reverse transcription polymerase chain reaction for the 3 most common KIAA1549-BRAF fusion... Read More about BRAF Fusion Analysis in Pilocytic Astrocytomas: KIAA1549-BRAF 15-9 Fusions Are More Frequent in the Midline Than Within the Cerebellum.

The psychological well-being and appearance concerns of patients presenting with ptosis (2014)
Journal Article
White, P., Rumsey, N., Jenkinson, E., Richards, H. S., Jenkinson, E., Rumsey, N., …Harrad, R. A. (2014). The psychological well-being and appearance concerns of patients presenting with ptosis. Eye, 28(3), 296-302. https://doi.org/10.1038/eye.2013.264

PurposePtosis affects both the function and appearance of the eyes and face, because of drooping of the eyelids. Previous research has focused on functional impairment; however, similar appearance altering eye conditions have been demonstrated to hav... Read More about The psychological well-being and appearance concerns of patients presenting with ptosis.

Operative time and outcome of enhanced recovery after surgery after laparoscopic colorectal surgery (2014)
Journal Article
Harrison, O. J., Smart, N. J., White, P., Brigic, A., Carlisle, E. R., Allison, A. S., …Francis, N. K. (2014). Operative time and outcome of enhanced recovery after surgery after laparoscopic colorectal surgery. Journal- Society of Laparoendoscopic Surgeons, 18(2), 265-272. https://doi.org/10.4293/108680813X13753907291918

Background and Objectives: Combining laparoscopy and enhanced recovery provides benefit to short-term outcomes after colorectal surgery. Advances in training and techniques have allowed surgeons to operate on cases that are technically challenging an... Read More about Operative time and outcome of enhanced recovery after surgery after laparoscopic colorectal surgery.