Skip to main content

Research Repository

Advanced Search

Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer (2022)
Journal Article
Boulind, C. E., Gould, O., Costello, B. D. L., Allison, J., White, P., Ewings, P., …Francis, N. K. (2022). Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer. Cancers, 14(9), 2127. https://doi.org/10.3390/cancers14092127

Colorectal symptoms are common but only infrequently represent serious pathology, including colorectal cancer (CRC). A large number of invasive tests are presently performed for reassurance. We investigated the feasibility of urinary volatile organic... Read More about Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer.

Novel blood biomarkers that correlate with cognitive performance and hippocampal volumetry: Potential for early diagnosis of Alzheimer's disease (2019)
Journal Article
Hudd, F., Shiel, A., Harris, M., Bowdler, P., McCann, B., Tsivos, D., …Conway, M. E. (2019). Novel blood biomarkers that correlate with cognitive performance and hippocampal volumetry: Potential for early diagnosis of Alzheimer's disease. Journal of Alzheimer's Disease, 67(3), 931-947. https://doi.org/10.3233/JAD-180879

© 2019 - IOS Press and the authors. All rights reserved. Background: Differential diagnosis of people presenting with mild cognitive impairment (MCI) that will progress to Alzheimer's disease (AD) remains clinically challenging. Current criteria used... Read More about Novel blood biomarkers that correlate with cognitive performance and hippocampal volumetry: Potential for early diagnosis of Alzheimer's disease.

Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles (2019)
Journal Article
Smart, A., de Lacy Costello, B., White, P., Avison, M., Batty, C., Turner, C., …Ratcliffe, N. (2019). Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles. Journal of Pharmaceutical and Biomedical Analysis, 167, 59-65. https://doi.org/10.1016/j.jpba.2019.01.044

© 2019 Elsevier B.V. Antibiotic resistance is set to be an unprecedented threat to modern medicine. ‘Sniffing’ bacteria potentially offers a rapid way to determine susceptibility. A successful proof-of-principle study is described, using thermal deso... Read More about Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles.

Irritable bowel syndrome and active inflammatory bowel disease diagnosed by faecal gas analysis (2016)
Journal Article
Aggio, R. B., White, P., Jayasena, H., de Lacy Costello, B., Ratcliffe, N. M., & Probert, C. S. (2017). Irritable bowel syndrome and active inflammatory bowel disease diagnosed by faecal gas analysis. Alimentary Pharmacology and Therapeutics, 45(1), 82-90. https://doi.org/10.1111/apt.13822

© 2016 John Wiley & Sons Ltd Background: Inflammatory bowel disease and irritable bowel syndrome may present in a similar manner. Measuring faecal calprotectin concentration is often recommended to rule out inflammatory bowel disease, however, ther... Read More about Irritable bowel syndrome and active inflammatory bowel disease diagnosed by faecal gas analysis.

The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults (2013)
Journal Article
Jacobson, S. K., Lewis, D. A., Lewis, D., Brown, R., Williams, J., White, P., …Drake, M. J. (2013). The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults. Frontiers in Cellular and Infection Microbiology, 4(AUG), https://doi.org/10.3389/fcimb.2013.00041

The urinary microbiome of healthy individuals and the way it alters with ageing have not been characterized and may influence disease processes. Conventional microbiological methods have limited scope to capture the full spectrum of urinary bacterial... Read More about The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults.

Breath volatile analysis from patients diagnosed with harmful drinking, cirrhosis and hepatic encephalopathy: A pilot study (2013)
Journal Article
Ratcliffe, N. M., Costello, B. D. L., Khalid, T. Y., de Lacy Costello, B., Ewen, R., White, P., …Probert, C. S. (2013). Breath volatile analysis from patients diagnosed with harmful drinking, cirrhosis and hepatic encephalopathy: A pilot study. Metabolomics, 9(5), 938-948. https://doi.org/10.1007/s11306-013-0510-4

Hepatic encephalopathy (HE) is a neuropsychiatric state potentially complicating cirrhosis following the accumulation of toxic compounds that cross the blood-brain barrier and affect brain function; the compounds may undergo alveolar gas exchange and... Read More about Breath volatile analysis from patients diagnosed with harmful drinking, cirrhosis and hepatic encephalopathy: A pilot study.

A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace (2013)
Journal Article
Ratcliffe, N., Probert, C. S., Ewen, R., Khalid, T., White, P., De Lacy Costello, B., …Ratcliffe, N. M. (2013). A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace. PLoS ONE, 8(7), https://doi.org/10.1371/journal.pone.0069602

There is a need to reduce the number of cystoscopies on patients with haematuria. Presently there are no reliable biomarkers to screen for bladder cancer. In this paper, we evaluate a new simple in-house fabricated, GC-sensor device in the diagnosis... Read More about A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace.

Application of Similarity Coefficients to Predict Disease Using Volatile Organic Compounds (2010)
Journal Article
Probert, C. S., Smith, S., White, P., Redding, J., & Ratcliffe, N. M. (2010). Application of Similarity Coefficients to Predict Disease Using Volatile Organic Compounds. IEEE Sensors Journal, 10(1), 92-96. https://doi.org/10.1109/JSEN.2009.2035771

Measures of similarity are used to provide evidence in support of the conjecture that the presence and absence profile of a subset of volatile organic compounds found in urine differ between healthy (non-prostate cancer) male donors and prostate canc... Read More about Application of Similarity Coefficients to Predict Disease Using Volatile Organic Compounds.

Identification of Campylobacter infection in chickens from volatile faecal emissions (2008)
Journal Article
Garner, C. E., Smith, S., Elviss, N. C., Humphrey, T. J., White, P., Ratcliffe, N. M., & Probert, C. S. (2008). Identification of Campylobacter infection in chickens from volatile faecal emissions. Biomarkers, 13(4), 413-421. https://doi.org/10.1080/13547500801966443

Volatile organic compounds from chicken faeces were investigated as biomarkers for Campylobacter infection. Campylobacter are major poultry-borne zoonotic pathogens, colonizing the avian intestinal tract. Chicken faeces are the principal source of co... Read More about Identification of Campylobacter infection in chickens from volatile faecal emissions.

Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease (2007)
Journal Article
Garner, C. E., Smith, S., De Lacy Costello, B., White, P., Spencer, R., Probert, C. S., & Ratcliffe, N. M. (2007). Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease. FASEB Journal, 21(8), 1675-1688. https://doi.org/10.1096/fj.06-6927com

Little is known about the volatile organic compounds (VOCs) in feces and their potential health consequences. Patients and healthcare professionals have observed that feces often smell abnormal during gastrointestinal disease. The aim of this work wa... Read More about Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease.