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Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: Association with seminal vesicle invasion and biochemical recurrence (2014)
Journal Article
Hagen, R. M., Adamo, P., Karamat, S., Oxley, J., Aning, J. J., Gillatt, D., …Rhodes, A. (2014). Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: Association with seminal vesicle invasion and biochemical recurrence. American Journal of Clinical Pathology, 142(4), 533-540. https://doi.org/10.1309/AJCPH88QHXARISUP

© American Society for Clinical Pathology. Objectives: The proto-oncogene ETS-related gene (ERG) is consistently overexpressed in prostate cancer. Alternatively spliced isoforms of ERG have variable biological activities; inclusion of exon 11 (72 bas... Read More about Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: Association with seminal vesicle invasion and biochemical recurrence.

An old dog and new tricks: Genetic analysis of a Tudor dog recovered from the Mary Rose wreck (2014)
Journal Article
Zouganelis, G. D., Ogden, R., Nahar, N., Runfola, V., Bonab, M., Ardalan, A., …Scarlett, G. (2014). An old dog and new tricks: Genetic analysis of a Tudor dog recovered from the Mary Rose wreck. Forensic Science International, 245, 51-57. https://doi.org/10.1016/j.forsciint.2014.10.001

© 2014 Elsevier Ireland Ltd. The Tudor warship the Mary Rose sank in the Solent waters between Portsmouth and the Isle of Wight on the 19th of July 1545, whilst engaging a French invasion fleet. The ship was rediscovered in 1971 and between 1979 and... Read More about An old dog and new tricks: Genetic analysis of a Tudor dog recovered from the Mary Rose wreck.

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells (2014)
Journal Article
Jenkins, G. J., Johnson, G. E., Doak, S. H., Doherty, A. T., Scott, A. D., Chapman, K. E., …Thomas, A. (2014). Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis, 29(3), 155-164. https://doi.org/10.1093/mutage/geu008

Micronucleus (MN) induction is an established cytogenetic end point for evaluating structural and numerical chromosomal alterations in genotoxicity testing. A semi-automated scoring protocol for the assessment of MN preparations from human cell lines... Read More about Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells.

Molecular dynamics simulation of humic substances (2014)
Journal Article
Orsi, M. (2014). Molecular dynamics simulation of humic substances. Chemical and Biological Technologies in Agriculture, 1(1), https://doi.org/10.1186/s40538-014-0010-4

© 2014, Orsi. Humic substances (HS) are complex mixtures of natural organic material which are found almost everywhere in the environment, and particularly in soils, sediments, and natural water. HS play key roles in many processes of paramount impor... Read More about Molecular dynamics simulation of humic substances.

Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin? (2014)
Journal Article
Liverani, E., & Paul, C. (2014). Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin?. Receptors & Clinical Investigation, 1(1), https://doi.org/10.14800/rci.25

Adrenomedullin is a vasodilatatory peptide, important during the inflammation process and also able to regulate blood-brain barrier function. Adrenomedullin and its receptors have been shown to be glucocorticoid-dependent in many cell types, includin... Read More about Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin?.

The investigation of the hBCAT proteins in control and diseased human brains: Implications for glutamate toxicity in Alzheimer’s disease (2014)
Thesis
Hull, J. The investigation of the hBCAT proteins in control and diseased human brains: Implications for glutamate toxicity in Alzheimer’s disease. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/824745

Introduction & Aims: The distribution of the BCAT proteins has been extensively mapped in rodent models, and metabolic studies have established that BCAT transamination in the rodent brain is responsible for 30% of de novo glutamate synthesis. Howeve... Read More about The investigation of the hBCAT proteins in control and diseased human brains: Implications for glutamate toxicity in Alzheimer’s disease.

Hydrogen sulfide and cell signaling: Team player or referee? (2014)
Journal Article
Hancock, J. T., Hancock, J. T., & Whiteman, M. (2014). Hydrogen sulfide and cell signaling: Team player or referee?. Plant Physiology and Biochemistry, 78, 37-42. https://doi.org/10.1016/j.plaphy.2014.02.012

Hydrogen sulfide (H2S) has been postulated to be the third gasotransmitter, and along with other reactive compounds such as reactive oxygen species (ROS) and nitric oxide (NO) it is thought to be a key signalling molecule. Enzymes which generate H2S,... Read More about Hydrogen sulfide and cell signaling: Team player or referee?.

What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013 (2014)
Journal Article
Birder, L. A., Fry, C. H., Sahai, A., Vahabi, B., Kanai, A. J., & Birder, L. A. (2014). What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013. Neurourology and Urodynamics, 33(5), 602-605. https://doi.org/10.1002/nau.22558

Aims A biomarker is an entity that measures a normal or pathological process, or the response to an intervention. A biomarker must measure exclusively and be sufficiently sensitive to the process of interest. Alternatively, a biomarker may give clues... Read More about What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013.

An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo (2014)
Thesis
Dean, S. J. An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/823941

Introduction Triple negative breast cancers are defined by their lack of expression of HER, oestrogen receptors and progesterone receptors. They account for around 10-24% of cases. To define a cancer by the biomarkers it does not express is unsati... Read More about An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo.

Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662 (2014)
Journal Article
Blackburn, J., Burston, B., Shepherd, S., Bone, H., Blom, A., & Mansell, J. (2014). Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662

Metformin (Met) is a biguanide drug widely used in the treatment and management of non insulin-dependent diabetes mellitus. In recent years it has emerged that Met, by stimulating adenosine monophosphate-activated protein kinase (AMPK), can promote t... Read More about Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662.

Effects of mixing alcohol with caffeinated beverages on subjective intoxication: A systematic review and meta-analysis (2014)
Journal Article
Benson, S., Verster, J. C., Alford, C., & Scholey, A. (2014). Effects of mixing alcohol with caffeinated beverages on subjective intoxication: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 47, 16-21. https://doi.org/10.1016/j.neubiorev.2014.07.008

It has been suggested that mixing alcohol with energy drinks or other caffeinated beverages may alter the awareness of (or 'mask') intoxication. The proposed reduction in subjective intoxication may have serious consequences by increasing the likelih... Read More about Effects of mixing alcohol with caffeinated beverages on subjective intoxication: A systematic review and meta-analysis.

Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients (2014)
Journal Article
Anderson, E., & Salisbury, V. (2014). Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients. Advances in Biochemical Engineering Biotechnology, 145, 189-214. https://doi.org/10.1007/978-3-662-43619-6_6

© Springer-Verlag Berlin Heidelberg 2014. Bioluminescent bacterial biosensors can be used in a rapid in vitro assay to predict sensitivity to commonly used chemotherapy drugs in acute myeloid leukemia (AML). The nucleoside analog cytarabine (ara-C) i... Read More about Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients.

Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells (2014)
Journal Article
Tezera, L. B., Page, K., Rhakimova, A., Salisbury, V., & Davenport, V. (2014). Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells. Advances in Microbiology, 04(02), 81-93. https://doi.org/10.4236/aim.2014.42013

In this study, we investigate the potential for oral Lactobacilli (LB) to afford innate protection against nasopharyngeal coloniser Neisseria meningitidis serogroup B (NmB), which causes the bulk of UK meningococcal disease. Oral isolates of L. plant... Read More about Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells.

A review of the volatiles from the healthy human body (2014)
Journal Article
Ratcliffe, N. M., Al-Kateb, H., De Lacy Costello, B., de Lacy Costello, B., Amann, A., Al-Kateb, H., …Ratcliffe, N. M. (2014). A review of the volatiles from the healthy human body. Journal of Breath Research, 8(1), https://doi.org/10.1088/1752-7155/8/1/014001

A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported. 1840 VOCs have been assigned from breath (872), saliva (359), blood (154), milk (256), skin secretions (532) urin... Read More about A review of the volatiles from the healthy human body.

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl (2014)
Journal Article
Chapman, K., Thomas, A. D., Wills, J., Pfuhler, S., Doak, S. H., & Jenkins, G. J. (2014). Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl. Mutagenesis, 29(3), 165-175. https://doi.org/10.1093/mutage/geu011

Recent restrictions on the testing of cosmetic ingredients in animals have resulted in the need to test the genotoxic potential of chemicals exclusively in vitro prior to licensing. However, as current in vitro tests produce some misleading positive... Read More about Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl.

Microbial acetone oxidation in coastal seawater (2014)
Journal Article
Nightingale, P. D., Tarran, G. A., Dixon, J. L., Beale, R., & Sargeant, S. (2014). Microbial acetone oxidation in coastal seawater. Frontiers in Microbiology, 5(MAY), https://doi.org/10.3389/fmicb.2014.00243

Acetone is an important oxygenated volatile organic compound (OVOC) in the troposphere where it influences the oxidizing capacity of the atmosphere. However, the air-sea flux is not well quantified, in part due to a lack of knowledge regarding which... Read More about Microbial acetone oxidation in coastal seawater.