Effectiveness of the human oral microbe identification microarray in identifying periodontal pathogens: A Systematic review (2022)
Journal Article
Udoh, S., Adukwu, E., Varadi, A., & Saad, S. (2022). Effectiveness of the human oral microbe identification microarray in identifying periodontal pathogens: A Systematic review. Applied Microbiology, 2(3), 614-625. https://doi.org/10.3390/applmicrobiol2030047

The aim of this review was to investigate the effectiveness of the Human Oral Microbe Identification Microarray (HOMIM) in identifying and quantifying bacterial species of the oral microbiome in periodontal disease. The search for articles was conduc... Read More about Effectiveness of the human oral microbe identification microarray in identifying periodontal pathogens: A Systematic review.

Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants (2017)
Journal Article
Rajatileka, S., Odd, D., Robinson, M. T., Spittle, A. C., Dwomoh, L., Williams, M., …Varadi, A. (2018). Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants. Molecular Neurobiology, 55(3), 2013-2024. https://doi.org/10.1007/s12035-017-0462-1

© 2017, The Author(s). Preterm delivery is associated with neurodevelopmental impairment caused by environmental and genetic factors. Dysfunction of the excitatory amino acid transporter 2 (EAAT2) and the resultant impaired glutamate uptake can lead... Read More about Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants.

Rapid detection of pathological mutations and deletions of the haemoglobin beta gene (HBB) by High Resolution Melting (HRM) analysis and Gene Ratio Analysis Copy Enumeration PCR (GRACE-PCR) (2016)
Journal Article
Turner, A., Sasse, J., & Varadi, A. (2016). Rapid detection of pathological mutations and deletions of the haemoglobin beta gene (HBB) by High Resolution Melting (HRM) analysis and Gene Ratio Analysis Copy Enumeration PCR (GRACE-PCR). BMC Medical Genetics, 17, Article 75. https://doi.org/10.1186/s12881-016-0334-y

© 2016 The Author(s). Objectives: Inherited disorders of haemoglobin are the world's most common genetic diseases, resulting in significant morbidity and mortality. The large number of mutations associated with the haemoglobin beta gene (HBB) makes g... Read More about Rapid detection of pathological mutations and deletions of the haemoglobin beta gene (HBB) by High Resolution Melting (HRM) analysis and Gene Ratio Analysis Copy Enumeration PCR (GRACE-PCR).

Association between neonatal resuscitation and a single nucleotide polymorphism rs1835740 (2016)
Journal Article
Odd, D., Varadi, A., Rajatileka, S., Molnár, E., & Luyt, K. (2016). Association between neonatal resuscitation and a single nucleotide polymorphism rs1835740. Acta Paediatrica, 105(7), e307-e312. https://doi.org/10.1111/apa.13421

© 2016 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd. Aim The aim of this work was to test whether three single nucleotide polymorphisms (SNPs) implicated in glutamate homoeostasis or signalling and cellular survival are associated... Read More about Association between neonatal resuscitation and a single nucleotide polymorphism rs1835740.

Isolation of human genomic DNA for genetic analysis from premature neonates: A comparison between newborn dried blood spots, whole blood and umbilical cord tissue (2013)
Journal Article
Váradi, A., Molnár, E., Rajatileka, S., Luyt, K., El-Bokle, M., Williams, M., …Varadi, A. (2013). Isolation of human genomic DNA for genetic analysis from premature neonates: A comparison between newborn dried blood spots, whole blood and umbilical cord tissue. BMC Genetics, 14(105), https://doi.org/10.1186/1471-2156-14-105

Background: Genotyping requires biological sample collection that must be reliable, convenient and acceptable for patients and clinicians. Finding the most optimal procedure of sample collection for premature neonates who have a very limited blood vo... Read More about Isolation of human genomic DNA for genetic analysis from premature neonates: A comparison between newborn dried blood spots, whole blood and umbilical cord tissue.

MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway (2012)
Journal Article
Brozzi, F., Lajus, S., Diraison, F., Rajatileka, S., Hayward, K., Regazzi, R., …Varadi, A. (2012). MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway. Molecular Biology of the Cell, 23(22), 4444-4455. https://doi.org/10.1091/mbc.E12-05-0369

Myosin- and Rab-interacting protein (MyRIP), which belongs to the protein kinase A (PKA)–anchoring family, is implicated in hormone secretion. However, its mechanism of action is not fully elucidated. Here we investigate the role of MyRIP in myosin V... Read More about MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway.

Translationally controlled tumour protein (TCTP) is a novel glucose-regulated protein that is important for survival of pancreatic beta cells (2011)
Journal Article
Avent, N. D., Bommer, U. A., Diraison, F., Hayward, K., Sanders, K. L., Brozzi, F., …Varadi, A. (2011). Translationally controlled tumour protein (TCTP) is a novel glucose-regulated protein that is important for survival of pancreatic beta cells. Diabetologia, 54(2), 368-379. https://doi.org/10.1007/s00125-010-1958-7

Aims/hypothesis: This study used proteomics and biochemical approaches to identify novel glucose-regulated proteins and to unveil their role in pancreatic beta cell function. Translationally controlled tumour protein (TCTP) was identified to be one s... Read More about Translationally controlled tumour protein (TCTP) is a novel glucose-regulated protein that is important for survival of pancreatic beta cells.