All Outputs (2)

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk (2013)
Journal Article
Collard, T. J., Lane, J. D., Williams, A. C., Petherick, K. J., Petherick, K. J., Williams, A. C., …Greenhough, A. (2013). Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk. EMBO Journal, 32(13), 1903-1916. https://doi.org/10.1038/emboj.2013.123

The Wnt/β-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β-catenin signalling pathway as a negative regulator of both basal and stress-induc... Read More about Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk.

LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids (2013)
Journal Article
Williams, A. C., Emery, E. D., Collard, T. J., Smartt, H. J., Al-Kharusi, M. R., Al-Kharusi, M. H., …Paraskeva, C. (2013). LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids. Carcinogenesis, 34(5), 1150-1157. https://doi.org/10.1093/carcin/bgt020

Cyclooxygenase-2 is overexpressed in the majority of colorectal tumours leading to elevated levels of prostaglandin E2 (PGE2), promoting many hallmarks of cancer. Importantly, PGE2 is reported to enhance Wnt/β-catenin signalling in colorectal carcino... Read More about LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids.