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Multiple roles for the Wilms' tumor suppressor, WT1 (1999)
Journal Article
Davies, R., Moore, A., Schedl, A., Bratt, E., Miyahawa, K., Ladomery, M., …Hastie, N. (1999). Multiple roles for the Wilms' tumor suppressor, WT1. Cancer Research, 59, 1747s-1750s

Wilms' tumor is a childhood kidney tumor that is a striking example of the way that cancer may arise through development gone awry. A proportion of these tumors develop as a result of the loss of function mutations in the Wilms' tumor suppressor gene... Read More about Multiple roles for the Wilms' tumor suppressor, WT1.

Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes (1997)
Journal Article
Ladomery, M., Lyons, S., & Sommerville, J. (1997). Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes. Gene, 198(1-2), 275-280. https://doi.org/10.1016/S0378-1119%2897%2900325-9

Modification of core histones can alter chromatin structure, facilitating the activation and repression of genes. A key example is the acetylation of N-terminal lysines of the core histones. Recently, the mammalian histone deacetylase HD1 was cloned... Read More about Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes.

Multifunctional proteins suggest connections between transcriptional and post-transcriptional processes (1997)
Journal Article
Ladomery, M. (1997). Multifunctional proteins suggest connections between transcriptional and post-transcriptional processes. BioEssays, 19(10), 903-909. https://doi.org/10.1002/bies.950191010

Recent findings indicate that substantial cross-talk may exist between transcriptional and post-transcriptional processes. Firstly, there are suggestions that specific promoters influence the post-transcriptional fate of transcripts, pointing to comm... Read More about Multifunctional proteins suggest connections between transcriptional and post-transcriptional processes.

Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes (1997)
Journal Article
Ladomery, M., Wade, E., & Sommerville, J. (1997). Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes. Nucleic Acids Research, 25(5), 965-973

In investigating the composition of stored (maternal) mRNP particles in Xenopus oocytes, attention has focussed primarily on the phosphoproteins pp60/56, which are Y-box proteins involved in a general packaging of mRNA. We now identify a third, abund... Read More about Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes.

A role for Y‐box proteins in cell proliferation (1995)
Journal Article
Ladomery, M., & Sommerville, J. (1995). A role for Y‐box proteins in cell proliferation. BioEssays, 17(1), 9-11. https://doi.org/10.1002/bies.950170104

Members of the Y‐box (YB) family of transcription factors are expressed in a wide range of cell types and are implicated in the regulation of a rapidly increasing number of genes. Although the biological activities of YB proteins appear to be varied,... Read More about A role for Y‐box proteins in cell proliferation.

Binding of Y-box proteins to RNA: Involvement of different protein domains (1994)
Journal Article
Ladomery, M., & Sommerville, J. (1994). Binding of Y-box proteins to RNA: Involvement of different protein domains. Nucleic Acids Research, 22(25), 5582-5589

Eukaryotlc Y-box proteins are reported to interact with a wide variety of nucleic acid structures to act as transcription factors and mRNA masking proteins. The modular structure of Y-box proteins Includes a highly conserved N-termlnal cold-shock... Read More about Binding of Y-box proteins to RNA: Involvement of different protein domains.