All Outputs (7)

Investigating the disease-promoting abilities of gut bacteria in colorectal tumour cells (2021)
Thesis
Robson, J. Investigating the disease-promoting abilities of gut bacteria in colorectal tumour cells. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7434617

Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer-related death. The global burden of CRC is rising, particularly in younger populations. This increase has been attributed to lifestyle factor... Read More about Investigating the disease-promoting abilities of gut bacteria in colorectal tumour cells.

The experience of emotion in people with Fibromyalgia: A thematic analysis (2021)
Thesis
Jones, L. The experience of emotion in people with Fibromyalgia: A thematic analysis. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7045706

Emotion is widely recognised as one of the central factors which influence the experience and management of pain (International Association for the Study of Pain, 2020). There is a substantial research base on how emotion may exacerbate or ameliorate... Read More about The experience of emotion in people with Fibromyalgia: A thematic analysis.

Bridging in vitro and in vivo testing: The utilisation of a novel in vitro three-dimensional model of human bone marrow for toxicity and genotoxicity testing (2021)
Thesis
Vernon, A. Bridging in vitro and in vivo testing: The utilisation of a novel in vitro three-dimensional model of human bone marrow for toxicity and genotoxicity testing. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7043785

Genotoxicity testing is required for all new compounds utilising 2D assays, such as the in vitro micronucleus (MN) assay, before moving to in vivo assays such as the rodent bone marrow MN assay. Two-dimensional cell culture has traditionally been use... Read More about Bridging in vitro and in vivo testing: The utilisation of a novel in vitro three-dimensional model of human bone marrow for toxicity and genotoxicity testing.

Investigation of haematopoietic stem cell homing post-transplantation using an in vitro model of the bone marrow/vasculature interface (2021)
Thesis
Almalki, S. Investigation of haematopoietic stem cell homing post-transplantation using an in vitro model of the bone marrow/vasculature interface. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6000940

Homing of haematopoietic stem cells (HSCs) to the bone marrow (BM) niches after transplantation (HSCT) is controlled by chemotactic signalling released from the BM microenvironment. This process is incompletely understood, but some factors are known,... Read More about Investigation of haematopoietic stem cell homing post-transplantation using an in vitro model of the bone marrow/vasculature interface.

Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia (2021)
Thesis
Wodi, C. Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490771

This study was aimed at investigating the effect of inhibiting SRPK1 in leukaemic cells. It was also aimed at exploring the potential utility of combining conventional leukaemia chemotherapy (such as imatinib) with compounds that inhibit SRPK1. SR... Read More about Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia.

Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects (2021)
Thesis
Ude, A. Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6971684

Advances in modern chemotherapeutic regimens have led to an increase in the overall survival of leukaemia patients in recent years. However, haematopoietic stem cell transplantation (HSCT) remains the curative option for these patients. In HSCT, high... Read More about Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects.

The implementation, impact and effectiveness of surveillance systems on the prevention and transmission of carbapenemase-producing organisms (2021)
Thesis
Henderson, J. The implementation, impact and effectiveness of surveillance systems on the prevention and transmission of carbapenemase-producing organisms. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6093082

Carbapenems are broad spectrum antibiotics often reserved for the critically ill. Their increased and, often, inappropriate use, has led to the development of resistance, through acquisition of carbapenemase enzymes. There are five carbapenemases tha... Read More about The implementation, impact and effectiveness of surveillance systems on the prevention and transmission of carbapenemase-producing organisms.