Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation
(2020)
Journal Article
Matta, C., Fellows, C. R., Quasnichka, H., Williams, A., Jeremiasse, B., Allaway, D., & Mobasheri, A. (2021). Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation. Journal of Orthopaedic Research, 39(5), 1017-1029. https://doi.org/10.1002/jor.24814
The protein clusterin has been implicated in the molecular alterations that occur in articular cartilage during osteoarthritis (OA). Clusterin exists in two isoforms with opposing functions, and their roles in cartilage have not been explored. The se... Read More about Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation.